1,774 results match your criteria: "University of North Carolina at Chapel Hill School of Medicine.[Affiliation]"

Purpose: The Democratic Republic of Congo has one of the highest burdens of malaria in the world, accounting for 12.3% of malaria cases and 11.6% of malaria deaths.

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Background: Food insecurity poses a substantial threat to mental health. However, there is limited understanding of how food-insecure adults experience mental health challenges and access necessary health services. We examined the association of food insecurity with mental health status, mental health service utilisation and general healthcare utilisation among US adults.

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Impact of white matter hyperintensity volume on cognition among US Mexican American adults.

J Int Neuropsychol Soc

December 2024

Department of Radiology and Biomedical Research Imaging Center, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, USA.

Objective: Higher white matter hyperintensity (WMH) volume is a marker of cardiovascular disease (CVD) risk. CVD risk factors increase risk for Alzheimer's disease and related dementias (ADRD). Mexican Americans (MA) and individuals of other Hispanic/Latino heritages have higher risk for CVD and ADRD.

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  • A 70-year-old man with multiple health issues and intellectual disability was a patient for five years, illustrating the complexities of primary care medicine.
  • His case raised ethical questions regarding the treatment of patients who cannot make decisions for themselves, highlighting the need for dignity and respect in care.
  • Despite the challenges, his care experience revealed both the shortcomings of the US healthcare system and the positive outcomes of coordinated, team-based care, emphasizing the importance of human connections in primary care.
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  • The study investigates how factors like race and socioeconomic status affect maternal presence in the Neonatal Intensive Care Unit (NICU), with a focus on mothers of Black infants.
  • It finds that Medicaid status significantly predicts lower maternal presence rates, particularly among mothers with lower socioeconomic status.
  • The authors suggest that interventions must target the resource-related challenges faced by low-SES mothers to improve their ability to be present in the NICU.
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Objective: The primary aim of this study was to examine sex differences in energy availability (EA) and its relationships with disordered eating, compulsive exercise, and body mass index (BMI) among adolescent athletes.

Design: Cross-sectional study.

Setting: University hospital pediatric sports medicine center.

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Research news in clinical context.

Sex Transm Infect

November 2024

Department of Genitourinary Medicine and Infectious Diseases, St. James's Hospital, Dublin 8, Ireland.

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  • The 2023 American Epilepsy Society Annual Course focused on the importance of timing in evaluating and treating epilepsy, especially for vulnerable populations and those facing health disparities.
  • The course covered a wide range of topics, including gaps in epilepsy care, behavioral health optimization, seizure forecasting, and treatment timing for various seizure types and conditions.
  • Key discussions included the role of neuromodulation versus surgery, strategies for autoimmune-associated epilepsy, dietary therapy, and leveraging new biomarkers in collaboration with neuropsychological outcomes.
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Introduction: Abdominal binders consist of a wide compression belt that encircles the abdomen, theoretically supporting the abdominal wall. However, their use after ventral hernia repair is debated. Therefore, this meta-analysis evaluates their efficacy.

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Innovating Diabetes Care in Pregnancy: Do group care models improve outcomes and equity?

Diabetes

November 2024

Department of Obstetrics and Gynecology, Division of Maternal-Fetal Medicine, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina. Department of Obstetrics and Gynecology, Division of Maternal-Fetal Medicine, Washington University School of Medicine, St. Louis, Missouri.

Shared medical appointments (SMAs) for diabetes and group prenatal care (GPC) for pregnant patients, have emerged as innovative care delivery models. They have the potential to transform diabetes care by overcoming many of the time limitations of traditional one-on-one clinical visits. There is compelling evidence that SMAs improve glycemic control for non-pregnant patients with diabetes, GPC reduces Black/White health disparities in preterm birth, and Diabetes Group Prenatal Care increase postpartum glucose tolerance test uptake among patients with gestational diabetes mellitus.

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Background: Exercise is beneficial for persons with schizophrenia; however, high dropout rates limit the impact of interventions. Virtual exercise programs have the potential to improve engagement; however, few intervention studies of virtual programs have been conducted in this population.

Methods: This study examined qualitative data from 15 adults with schizophrenia who participated in a pilot randomized controlled trial of Virtual PACE-Life, a live, video-delivered group walking intervention guided by self-determination theory.

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  • - The study investigates attention problems in children born preterm (<30 weeks gestation) from ages 2 to 5, analyzing factors that influence these attention trajectories and their relationship to ADHD diagnoses.
  • - Using data from 608 infants in a large prospective study, researchers found that while most children displayed low initial attention problems, there were notable individual differences in symptom progression over time.
  • - The findings indicate that children with higher initial attention issues and faster increases in symptoms are at a greater risk for an ADHD diagnosis, highlighting the need for tailored interventions based on individual characteristics.
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Systematic Review of Obstetric and Child Outcomes of Prenatal Exposure to Inhalants in the Context of a Use Disorder.

J Addict Med

November 2024

From the University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC (ESK); Addiction Medical Services of Wisconsin, Onalaska, WI (CWS); Health Sciences Library, University of North Carolina at Chapel Hill, Chapel Hill, NC (JLC); and Horizons Division and Department of Obstetrics and Gynecology, University of North Carolina at Chapel Hill, Chapel Hill, NC, and Departments of Psychiatry and Behavioral Sciences and Obstetrics and Gynecology, School of Medicine, Johns Hopkins University, Baltimore, MD (HEJ).

Objectives: Inhalants are often used for their psychoactive effects, producing feelings of euphoria. Inhalant and solvent use is a serious public health concern, yet little is known about their effects on perinatal, fetal, and child outcomes. The aim of our review is to evaluate the impact of inhalant use by pregnant people on maternal, fetal, neonatal, and early childhood outcomes.

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Purpose: P300 is a lysine acetyltransferase that plays a significant role in regulating transcription and the nuclear acetylome. While P300 has been shown to be required for the transcription of certain early flow responsive genes, relatively little is known about its role in the endothelial response to hemodynamic fluid stress. Here we sought to define the role of P300 in mechanotransduction of fluid shear stress in the vascular endothelium.

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: Spaced repetition flashcards and other instructor-made resources are beneficial tools for students in content-dense introductory courses, particularly in the sciences. This study seeks to evaluate whether instructor-made, spaced repetition flashcards affect students' performance on the exams and their self-concept as it pertains to a newly introduced discipline (microbiology). : Students enrolled in a bachelor's level introductory microbiology course utilized a spaced repetition flashcard software to scaffold their review of course material productively.

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  • Metabolic activity is crucial for regulating macrophage function, with pro-inflammatory types favoring glycolysis and pro-repair types relying on oxidative processes.
  • This study investigates how the metabolism of alveolar macrophages (AM) in mice responds to LPS stimulation, compared to bone marrow-derived macrophages (BMDM).
  • Findings show that AM have higher oxygen consumption and fatty acid oxidation; when glutamine metabolism is inhibited, AM alter their metabolic activity and response to LPS differently than BMDM.
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Objective: The goal of this study was to assess predictive factors for receiving interviews and matching in general surgery (GS), cardiothoracic surgery (TS), vascular surgery (VS), and plastic surgery (PS).

Design: The Texas Seeking Transparency in Applications to Residency (STAR) survey was analyzed for match years 2018-2023. Chi-Square Tests of Independence were used to assess differences among participants who received ≥16 vs <16 interviews and, separately, participants who matched vs went unmatched.

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Female Genital Mutilation/Cutting (FGM/C) and child marriage are prevalent in many countries in Asia and Africa. These practices are a violation of human rights and have significant impacts on the physical and mental well-being of those affected. COVID-19 restrictions such as lockdowns and closure of schools may have influenced the occurrence of FGM/C and child marriage.

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  • Many cisgender women in the US who have been incarcerated are at a higher risk for HIV after re-entering the community, prompting the study to investigate the factors that affect their HIV prevention choices, like Pre-Exposure Prophylaxis (PrEP).
  • Researchers conducted interviews with 32 participants to gather data on their social networks, including important relationships, demographics, and how these relationships influenced their decisions regarding HIV prevention.
  • Findings showed that factors such as non-heterosexual identity, older age within their networks, and having a sexual partner were positive indicators of influential relationships in making decisions about PrEP, while certain negative factors were also identified in relation to influence.
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  • - Sjögren's disease (SD) is an autoimmune condition linked to specific autoantibodies, and a case study showed that a previously healthy individual developed SD after primary Epstein-Barr virus (EBV) infection, resulting in multiple autoantibody productions.
  • - Researchers examined immune responses to various autoantigens and found that anti-Ro52 and anti-Ro60 autoantibodies started to appear shortly after EBV infection, with levels continuing to rise alongside other antibodies long after the initial infection.
  • - The study concludes that EBV infection can trigger specific autoantibody responses through different mechanisms, and it notes that some healthy individuals can produce certain autoantibodies independently of the EBV response.
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Purpose: This cross-sectional survey study quantified the humanistic burden of immunoglobulin A nephropathy (IgAN), in terms of physical and mental health-related quality of life (HRQoL) and work productivity, among adults with primary IgAN and their care-partners.

Methods: HRQoL was assessed (01/31/22 - 05/31/23) with validated tools including the KDQoL-36 (with SF-12), GAD-7 (anxiety), PHQ-9 (depression), and WPAI: SHP (work productivity). Participant characteristics and total/domain scores were summarized; selected outcomes were compared to an external, kidney disease-free cohort.

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Cutaneous immune-related adverse events (irAEs) of immunotherapies, such as anti-programmed cell death protein-1 (PD-1), suggest that immune checkpoint factors may contribute to the pathobiology of lichenoid interface dermatitis in immunotherapy-naïve patients. Our study aimed to describe innate and adaptive immune markers via immunohistochemical (IHC) staining of lichenoid interface dermatoses. We studied the staining patterns of PD-L1, STING, IL-36 gamma, CD8, PD-1, and LAG-3 in five interface dermatoses: oral lichen planus (LP) (n = 10), cutaneous LP (n = 10), chronic cutaneous lupus erythematosus (CLE) (n = 11), erythema multiforme (EM) (n = 11), and toxic epidermal necrolysis (TEN) (n = 13), by immunohistochemistry (IHC) analysis.

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Background: HPTN 084 compared the safety and efficacy of long-acting injectable cabotegravir (CAB) to daily oral TDF/FTC for prevention of HIV-1 in uninfected African women. Like a similar trial in MSM/TGW (HPTN 083), the trial was stopped early for efficacy, expediting the need to consider introduction strategies for different populations. We examine survey and qualitative data from a four-country sub-study to examine oral and injectable PrEP acceptability and considerations for CAB access among African women.

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