1,761 results match your criteria: "University of North Carolina at Chapel Hill School of Medicine[Affiliation]"
Ann Thorac Surg
December 2024
Ascension Saint Thomas Hospital, University of Tennessee Health Science Center, Division of Thoracic Surgery, Nashville, TN.
Objective: With robotic technology's rapid growth and integration, an urgent need to bridge the educational gap in thoracic surgical training has emerged. This document, a result of consensus among a group of experts in the practice and training of robotic surgery from the Society of Thoracic Surgeons (STS), aims to provide a framework for a standardized national robotic curriculum for thoracic surgery trainees.
Methods: The STS Task Force on Robotic Thoracic Surgery and Workforce on E-learning and Educational Innovation assembled an expert group with the input of the Thoracic Surgery Director's Association (TSDA).
Proc Natl Acad Sci U S A
December 2024
Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC 27599.
Adaptor protein complex-3 (AP-3) mediates cargo sorting from endosomes to lysosomes and lysosome-related organelles. Recently, it was shown that AP-3 adopts a constitutively open conformation compared to the related AP-1 and AP-2 coat complexes, which are inactive until undergoing large conformational changes upon membrane recruitment. How AP-3 is regulated is therefore an open question.
View Article and Find Full Text PDFJCI Insight
December 2024
Center for Vaccine Innovation, La Jolla Institute for Immunology, La Jolla, California, USA.
T cells are involved in protective immunity against numerous viral infections. Data regarding functional roles of human T cells in SARS-CoV-2 (SARS2) viral clearance in primary COVID-19 are limited. To address this knowledge gap, we assessed samples for associations between SARS2 upper respiratory tract viral RNA levels and early virus-specific adaptive immune responses for 95 unvaccinated clinical trial participants with acute primary COVID-19 aged 18-86 years old, approximately half of whom were considered at high risk for progression to severe COVID-19.
View Article and Find Full Text PDFSci Adv
December 2024
Section Editor, Biomedicine and Life Sciences, Science Advances, Department of Microbiology and Immunology, University of North Carolina at Chapel Hill School of Medicine, 125 Mason Farm Road, Chapel Hill, NC 27599, USA.
J Clin Invest
December 2024
Department of Medicine and Department of Biochemistry and Molecular Biology, UF Health Cancer Center, University of Florida, Gainesville, Florida, USA.
Ecotropic viral integration site 1 (EVI1/MECOM) is frequently upregulated in myeloid malignancies. Here, we present an Evi1-transgenic mouse model with inducible expression in hematopoietic stem/progenitor cells (HSPCs). Upon induction of Evi1 expression, mice displayed anemia, thrombocytopenia, lymphopenia, and erythroid and megakaryocyte dysplasia with a significant expansion of committed myeloid progenitor cells, resembling human myelodysplastic syndrome/myeloproliferative neoplasm-like (MDS/MPN-like) disease.
View Article and Find Full Text PDFClin Transl Sci
December 2024
Division of Pharmacotherapy and Experimental Therapeutics, University of North Carolina at Chapel Hill Eshelman School of Pharmacy, Chapel Hill, North Carolina, USA.
Venetoclax is a first-in-class orally administered B-cell lymphoma-2 inhibitor used to treat chronic lymphocytic leukemia (CLL). Venetoclax is primarily metabolized in the liver by cytochrome P450 (CYP) 3A4 to its major metabolite M27, via M5, and M2, M3, and M4 via oxidation. Although venetoclax is a breakthrough in CLL treatment, managing drug safety and toxicity remains a clinical challenge.
View Article and Find Full Text PDFNucleic Acids Res
December 2024
Department of Pharmacology, University of South Alabama, 5795 USA Drive North, Mobile, AL 36688, USA.
Several studies have now described instances where G-rich sequences in promoters and enhancers regulate gene expression through forming G-quadruplex (G4) structures. Relatedly, our group recently identified 301 long genomic stretches significantly enriched for minimal G4 motifs (LG4s) in humans and found the majority of these overlap annotated enhancers, and furthermore, that the promoters regulated by these LG4 enhancers are similarly enriched with G4-capable sequences. While the generally accepted model for enhancer:promoter specificity maintains that interactions are dictated by enhancer- and promoter-bound transcriptional activator proteins, the current study tested an alternative hypothesis: that LG4 enhancers interact with cognate promoters via a direct G4:G4 DNA-based mechanism.
View Article and Find Full Text PDFJ Palliat Med
December 2024
Departments of Neurology, Neurosurgery and Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Palliative care (PC) is essential to improve quality of life for individuals with life-limiting acute neurological conditions, particularly in resource-limited settings. In Latin America and the Caribbean (LAC), there is limited health care professional training and education on PC. We reviewed the peer-reviewed literature discussing end-of-life care, withdrawal of life-sustaining treatments (WOLST), and PC in the acute inpatient setting.
View Article and Find Full Text PDFAm J Gastroenterol
September 2024
Division of Pediatric Gastroenterology, Department of Pediatrics, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina, USA.
Nat Commun
November 2024
Division of Solid Organ Transplant, Department of Surgery, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Surgery
November 2024
Department of Surgery, Cleveland Clinic Center for Abdominal Core Health Cleveland Clinic Foundation, Cleveland, OH.
Background: Traumatic abdominal wall hernias are rare and commonly involve the lateral abdominal wall due to shearing off the oblique and transversus abdominis muscles from the iliac crest. The vast majority of the current literature focuses on the index trauma admission, includes few patients, and provides little to no detail about the hernia repair itself. We aim to report our center's high-volume experience with a definitive repair of chronic traumatic lateral abdominal wall hernias.
View Article and Find Full Text PDFBMJ Open
November 2024
School of Public Heath, University of Kinshasa, Kinshasa, Democratic Republic of Congo.
J Epidemiol Community Health
November 2024
Division of General Medicine and Clinical Epidemiology, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina, USA.
Background: Food insecurity poses a substantial threat to mental health. However, there is limited understanding of how food-insecure adults experience mental health challenges and access necessary health services. We examined the association of food insecurity with mental health status, mental health service utilisation and general healthcare utilisation among US adults.
View Article and Find Full Text PDFJ Int Neuropsychol Soc
November 2024
Department of Radiology and Biomedical Research Imaging Center, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, USA.
Objective: Higher white matter hyperintensity (WMH) volume is a marker of cardiovascular disease (CVD) risk. CVD risk factors increase risk for Alzheimer's disease and related dementias (ADRD). Mexican Americans (MA) and individuals of other Hispanic/Latino heritages have higher risk for CVD and ADRD.
View Article and Find Full Text PDFAnn Fam Med
November 2024
Department of Family Medicine, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina
J Perinatol
November 2024
Department of Maternal and Child Health, Gillings School of Global Public Health University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Objective: Maternal presence in the Neonatal Intensive Care (NICU) supports infant and maternal health, yet mothers face visitation challenges. Based on intersectionality theory, we hypothesized that mothers of Black infants with lower socioeconomic status (SES) living further from the hospital would demonstrate the lowest rates of maternal presence.
Study Design: We extracted infant race, Medicaid status, and maternal home address from 238 infant medical charts.
Clin J Sport Med
November 2024
Department of Orthopedics, University of Colorado School of Medicine, Aurora, Colorado.
Objective: The primary aim of this study was to examine sex differences in energy availability (EA) and its relationships with disordered eating, compulsive exercise, and body mass index (BMI) among adolescent athletes.
Design: Cross-sectional study.
Setting: University hospital pediatric sports medicine center.
Sex Transm Infect
November 2024
Department of Genitourinary Medicine and Infectious Diseases, St. James's Hospital, Dublin 8, Ireland.
Epilepsy Curr
April 2024
Neurology, Cleveland Clinic Children's Hospital, Cleveland, OH, USA.
Hernia
November 2024
Department of Surgery, The University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, USA.
Introduction: Abdominal binders consist of a wide compression belt that encircles the abdomen, theoretically supporting the abdominal wall. However, their use after ventral hernia repair is debated. Therefore, this meta-analysis evaluates their efficacy.
View Article and Find Full Text PDFDiabetes
November 2024
Department of Obstetrics and Gynecology, Division of Maternal-Fetal Medicine, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina. Department of Obstetrics and Gynecology, Division of Maternal-Fetal Medicine, Washington University School of Medicine, St. Louis, Missouri.
Shared medical appointments (SMAs) for diabetes and group prenatal care (GPC) for pregnant patients, have emerged as innovative care delivery models. They have the potential to transform diabetes care by overcoming many of the time limitations of traditional one-on-one clinical visits. There is compelling evidence that SMAs improve glycemic control for non-pregnant patients with diabetes, GPC reduces Black/White health disparities in preterm birth, and Diabetes Group Prenatal Care increase postpartum glucose tolerance test uptake among patients with gestational diabetes mellitus.
View Article and Find Full Text PDFBMC Psychiatry
November 2024
Department of Psychiatry, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, USA.
Background: Exercise is beneficial for persons with schizophrenia; however, high dropout rates limit the impact of interventions. Virtual exercise programs have the potential to improve engagement; however, few intervention studies of virtual programs have been conducted in this population.
Methods: This study examined qualitative data from 15 adults with schizophrenia who participated in a pilot randomized controlled trial of Virtual PACE-Life, a live, video-delivered group walking intervention guided by self-determination theory.
J Child Psychol Psychiatry
November 2024
Department of Psychiatry and Human Behavior, Warren Alpert Medical School of Brown University, Providence, RI, USA.