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Laxative Abuse Is Associated With a Depleted Gut Microbial Community Structure Among Women and Men With Binge-Eating Disorder or Bulimia Nervosa: The Binge Eating Genetics Initiative.
Psychosom Med
October 2023
From the Department of Nutrition (Igudesman, Reed, Bulik, Carroll), University of North Carolina at Chapel Hill, Chapel Hill, North Carolina; Department of Medical Epidemiology and Biostatistics (Abbaspour, Bulik) Karolinska Institutet, Stockholm, Sweden; Department of Psychology and Neuroscience (Flatt), University of North Carolina at Chapel Hill, Chapel Hill, North Carolina; Division of Pediatric Infectious Diseases (Becken), University of Nebraska Medical Center, Omaha, Nebraska; and Department of Psychiatry, University of North Carolina at Chapel Hill (Thornton, Bulik), Chapel Hill, North Carolina.
Objective: This study assessed the associations of binge eating, compensatory behaviors, and dietary restraint with the composition and diversity of the intestinal microbiota among participants with binge-eating disorder or bulimia nervosa.
Methods: We analyzed data from 265 participants aged 18 to 45 years with current binge-eating disorder or bulimia nervosa enrolled in the Binge Eating Genetics Initiative study. We evaluated the associations of binge-eating frequency; presence/absence and frequency of vomiting, laxative use, and compulsive exercise; and dietary restraint with abundances of gut microbial genera, species, and diversity (Shannon diversity, Faith phylogenetic diversity, and Peilou's evenness) from 16S rRNA gene sequencing.