10 results match your criteria: "University of North Carolina Hospitals Chapel Hill[Affiliation]"
In the pediatric age group, FXIII deficiency can present as abnormal or delayed bleeding from the umbilical stump, soft tissue and subcutaneous bleeding, intracerebral hemorrhages, intraoral bleeding, and poor wound healing. This case report describes an atypical presentation of FXIII deficiency in a 3-year-old female who presented to the emergency department with complaints of abdominal pain and vomiting. She was managed conservatively under the care of the pediatric surgery team.
View Article and Find Full Text PDFThree-Year Outcomes in Recipients of Mismatched Unrelated Bone Marrow Donor Transplants Using Post-Transplantation Cyclophosphamide: Follow-Up from a National Marrow Donor Program-Sponsored Prospective Clinical Trial.
Transplant Cell Ther
March 2023
The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland.
Article Synopsis
- * A clinical trial involving 80 patients treated with either myeloablative or reduced-intensity conditioning demonstrated a 3-year overall survival rate of 70% for the reduced-intensity group and 62% for the myeloablative group, with no reported GVHD after one year.
- * The findings highlight the potential benefits of PTCy in mismatched unrelated donor HCT, though further research is needed to address issues like relapse rates and optimal donor
Evaluation and Management of Heart Block After Transcatheter Aortic Valve Replacement.
Card Fail Rev
March 2021
Division of Cardiology, Department of Medicine, University of North Carolina Hospitals Chapel Hill, NC, US.
Transcatheter aortic valve replacement (TAVR) has developed substantially since its inception. Improvements in valve design, valve deployment technologies, preprocedural imaging and increased operator experience have led to a gradual decline in length of hospitalisation after TAVR. Despite these advances, the need for permanent pacemaker implantation for post-TAVR high-degree atrioventricular block (HAVB) has persisted and has well-established risk factors which can be used to identify patients who are at high risk and advise them accordingly.
View Article and Find Full Text PDFPurpose: Hematopoietic cell transplantation (HCT) is curative for hematologic disorders, but outcomes are historically inferior when using HLA-mismatched donors. Despite unrelated donor registries listing > 38 million volunteers, 25%-80% of US patients lack an HLA-matched unrelated donor, with significant disparity across ethnic groups. We hypothesized that HCT with a mismatched unrelated donor (MMUD) using post-transplant cyclophosphamide (PTCy), a novel strategy successful in overcoming genetic disparity using mismatched related donors, would be feasible and increase access to HCT.
View Article and Find Full Text PDFEvaluating the Efficacy and Use of Vein Visualization Equipment Among Clinical Nurses in an Intermediate Care Environment.
J Infus Nurs
October 2018
University of North Carolina Hospitals, Hillsborough, North Carolina (Mr Kanipe); Medical Intensive Care Unit, University of North Carolina Hospitals at Chapel Hill, Chapel Hill, North Carolina (Ms Kime); University of North Carolina Hospitals Chapel Hill, North Carolina (Dr Smith-Miller); Duke University Medical Center, Durham, North Carolina (Ms Shobe); and University of Florida School of Nursing, Gainesville, Florida (Dr Li). William Kanipe, BSN, RN, PCCN, was the principal investigator on this study. At the time of the study, Mr Kanipe was the assistant nurse manager on the unit where the research was conducted. He is now a nurse manager at the University of North Carolina Hospitals-Hillsborough campus. Kellie Shobe, MS, BSN, RN, PCCN, was the coprincipal investigator on this study. At the time of this study, Ms Shobe was a clinical nurse on the unit where the research was conducted. Yin Li, PhD, BM, RN, was a PhD candidate at the University of North Carolina at Chapel Hill School of Nursing during the preparation phase of this project. She assisted the research team with data analysis and interpretation. Dr Li is now a postdoctoral fellow at the University of Florida. Mary Kime, MSN, RN, is a clinical nurse in the medicine intensive care unit at the University of North Carolina Hospitals at Chapel Hill and is a PhD student at the University of North Carolina Greensboro School of Nursing. Ms Kime assisted with the development of the manuscript. Cheryl A. Smith-Miller, PhD, RN-BC, is currently serving as nurse scientist at University of North Carolina Hospitals. Her focus is on facilitating clinical nurses' engagement in research. Dr Smith-Miller assisted the research team with study design and manuscript development.
This study compared traditional short peripheral catheter (SPC) insertion methods with 2 vein visualization equipment models among a general patient population on a surgical step-down unit based on first-attempt success rates and the time required to achieve catheter insertion. The experiences of clinical nurses using the ultrasound and vein visualization equipment were also explored. No significant statistical differences were found between the insertion methods, based on 90 unique SPC insertion attempts.
View Article and Find Full Text PDFA theoretical framework for treating perinatal depression using couple-based interventions.
Psychotherapy (Chic)
December 2017
Department of Psychiatry, University of North Carolina Hospitals-Chapel Hill.
Between 10% and 20% of women will experience depression in the perinatal period, which begins during pregnancy and extends into the first year after delivery. Perinatal depression (PD) is associated with significant emotional and social impairments that impact women, their children, and their partners. Although the majority of women with PD do not seek treatment, a considerable proportion of those who engage in treatment do not achieve remission.
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