Order in the Interference of a Long Chain of Bose Condensates with Unrestricted Phases.

For a long periodic chain of Bose condensates prepared in the free space, the subsequent evolution and interference dramatically depend on the difference between the phases of the adjacent and more distant condensates. If the phases are equal, the initial periodic density distribution reappears at later times, which is known as the Talbot effect. For randomly related phases, we have found that a spatial order also appears in the interference, while the evolution of the fringes differs with the Talbot effect qualitatively.

The (CFC(O)NH)(CHCHNH)P(O) phosphoric triamide as a novel carrier with excellent efficiency for Cu(ii) in a liquid membrane transport system.

Transport of Ag(i), Cd(ii), Co(ii), Cu(ii), Ni(ii), Pb(ii) and Zn(ii) cations across a bulk liquid membrane (BLM) containing ,'-dibenzyl--(2,2,2-trifluoroacetyl)-phosphoric triamide (PTC) as a new carrier is studied by atomic absorption spectrometry. The results show selective and efficient transport of the copper(ii) cation from aqueous solution in the presence of the other cations. Various factors are optimized in order to obtain maximum transport efficiency.

Effect of ionizing radiation on physiological and molecular processes in plants.

The study of effects of ionizing radiation (IR) on plants is important in relation to several problems: (I) the existence of zones where background radiation - either natural or technogenic - is increased; (II) the problems of space biology; (III) the use of IR in agricultural selection; (IV) general biological problems related to the fundamental patterns and specifics of the effects of IR on various living organisms. By now, researchers have accumulated and systematized a large body of data on the effects of IR on the growth and reproduction of plants, as well as on the changes induced by IR at the genetic level. At the same time, there is a large gap in understanding the mechanisms of IR influence on the biochemical and physiological processes - despite the fact that these processes form the basis determining the manifestation of IR effects at the level of the whole organism.

Features of Neural Network Formation and Their Functions in Primary Hippocampal Cultures in the Context of Chronic TrkB Receptor System Influence.

Discovering the mechanisms underlying homeostatic regulation in brain neural network formation and stability processes is one of the most urgent tasks in modern neuroscience. Brain-derived neurotrophic factor (BDNF) and the tropomyosin-related kinase B (TrkB) receptor system have long been considered the main regulators of neuronal survival and differentiation. The elucidation of methods for studying neural network activity makes investigating the complex mechanisms underlying neural network structure reorganization during development and detecting new mechanisms for neuronal activity remodeling possible.

Radioprotective Role of Peroxiredoxin 6.

Peroxiredoxin 6 (Prdx6) is a member of an evolutionary ancient family of peroxidase enzymes with diverse functions in the cell. Prdx6 is an important enzymatic antioxidant. It reduces a wide range of peroxide substrates in the cell, thus playing a leading role in the maintenance of the redox homeostasis in mammalian cells.

Mechanisms of Supralinear Calcium Integration in Dendrites of Hippocampal CA1 Fast-Spiking Cells.

In fast-spiking (FS), parvalbumin-expressing interneurons of the CA1 hippocampus, activation of the GluA2-lacking Ca-permeable AMPA receptors (CP-AMPARs) in basal dendrites is coupled to Ca-induced Ca-release (CICR), and can result in a supralinear summation of postsynaptic Ca-transients (post-CaTs). While this mechanism is important in controlling the direction of long-term plasticity, it is still unknown whether it can operate at all excitatory synapses converging onto FS cells or at a set of synapses receiving a particular input. Using a combination of patch-clamp recordings and two-photon Ca imaging in acute mouse hippocampal slices with computational simulations, here we compared the generation of supralinear post-CaTs between apical and basal dendrites of FS cells.

Protective and adaptogenic role of peroxiredoxin 2 (Prx2) in neutralization of oxidative stress induced by ionizing radiation.

A radioprotective effect of exogenous recombinant peroxiredoxin 2 (Prx2) was revealed and characterized using an animal model of whole body X-ray irradiation at sublethal and lethal doses. Prx2 belongs to an evolutionarily ancient family of peroxidases that are involved in enzymatic degradation of a wide variety of organic and inorganic hydroperoxides. Apart from that, the oxidized form of Prx2 also exhibits chaperone activity, thereby preventing protein misfolding and aggregation under oxidative stress.

An emerging role for nanomaterials in increasing immunogenicity of cancer cell death.

In the last decade, it has become clear that anti-cancer therapy is more successful when it can also induce an immunogenic form of cancer cell death (ICD). ICD is an umbrella term covering several cell death modalities, including apoptosis and necroptosis. In general, ICD is characterized by the emission of damage-associated molecular patterns (DAMPs) and/or cytokines/chemokines, leading to the induction of strong anti-tumor immune responses.

Interaction of the anti-tuberculous drug bedaquiline with artificial membranes and rat erythrocytes.

Bedaquiline (BDQ) is a new drug from the family of diarylquinolines, which has a potent bactericidal activity against Mycobacterium tuberculosis. This paper has examined the interaction of BDQ with model membranes (liposomes and BLM) and rat erythrocytes. It was shown that BDQ (1-10 mol%) changed the thermotropic phase behavior of DMPC liposomes, leading to the lateral phase separation in the lipid bilayer and the formation of membrane microdomains.

Therapeutic Targeting of Connexin Channels: New Views and Challenges.

Connexins, in particular connexin 43 (Cx43), function as gap junction channels (GJCs) and hemichannels (HCs). Only recently, specific tools have been developed to study their pleiotropic functions. Based on various protein interaction sites, distinct connexin-mimetic peptides have been established that enable discrimination between the function of HCs and GJCs.

Unmodified hydrated С fullerene molecules exhibit antioxidant properties, prevent damage to DNA and proteins induced by reactive oxygen species and protect mice against injuries caused by radiation-induced oxidative stress.

Unmodified hydrated С fullerene molecules (CUHFM) were shown to reduce the formation ROS in water and 8-oxoguanine in DNA upon ionizing radiation impact. CUHFM efficiently eliminate long-lived protein radicals arising after irradiation. In irradiated mice CUHFM reduce the rate of single/double-strand DNA breaks and amount of chromosomal breaks.

Influence of wideband visible light with an padding red component on the functional state of mice embryos and embryonic stem cells.

It is known that visible light, including sunlight and laboratory lighting, adversely affect the development of embryos in vitro. In with article we present a technology for the synthesis of composite screens, capable to photoconvert UV and a part of the blue spectrum into red light with the maximum ~630 nm. It is established that the application of such transformed light with an evident red component raises the chances of embryos to survive and protects embryonic stem cells.

Membranotropic effects of ω-hydroxypalmitic acid and Ca on rat liver mitochondria and lecithin liposomes. Aggregation and membrane permeabilization.

The paper examines membranotropic Ca-dependent effects of ω-hydroxypalmitic acid (HPA), a product of ω-oxidation of fatty acids, on the isolated rat liver mitochondria and artificial membrane systems (liposomes). It was established that in the presence of Ca, HPA induced aggregation of liver mitochondria, which was accompanied by the release of cytochrome c from the organelles. It was further demonstrated that the addition of Ca to HPA-containing liposomes induced their aggregation and/or fusion.

AAV-Syn-BDNF-EGFP Virus Construct Exerts Neuroprotective Action on the Hippocampal Neural Network during Hypoxia In Vitro.

Unlabelled: Brain-derived neurotrophic factor (BDNF) is one of the key signaling molecules that supports the viability of neural cells in various brain pathologies, and can be considered a potential therapeutic agent. However, several methodological difficulties, such as overcoming the blood⁻brain barrier and the short half-life period, challenge the potential use of BDNF in clinical practice. Gene therapy could overcome these limitations.

Evaluation of N-H...S and N-H...π interactions in O,O'-diethyl N-(2,4,6-trimethylphenyl)thiophosphate: a combination of X-ray crystallographic and theoretical studies.

In the crystal structure of O,O'-diethyl N-(2,4,6-trimethylphenyl)thiophosphate, CHNOPS, two symmetrically independent thiophosphoramide molecules are linked through N-H...

Uhlmann curvature in dissipative phase transitions.

A novel approach based on the Uhlmann curvature is introduced for the investigation of non-equilibrium steady-state quantum phase transitions (NESS-QPTs). Equilibrium phase transitions fall invariably into two markedly non-overlapping categories: classical phase transitions and quantum phase transitions. NESS-QPTs offer a unique arena where such a distinction fades off.

Chemical Vapor Deposition of Photocatalyst Nanoparticles on PVDF Membranes for Advanced Oxidation Processes.

The chemical binding of photocatalytic materials, such as TiO₂ and ZnO nanoparticles, onto porous polymer membranes requires a series of chemical reactions and long purification processes, which often result in small amounts of trapped nanoparticles with reduced photocatalytic activity. In this work, a chemical vapor deposition technique was investigated in order to allow the nucleation and growth of ZnO and TiO₂ nanoparticles onto polyvinylidene difluoride (PVDF) porous membranes for application in advanced oxidation processes. The thickness of obtained surface coatings by sputtered nanoparticles was found to depend on process conditions.

Symmetric Logarithmic Derivative of Fermionic Gaussian States.

In this article, we derive a closed form expression for the symmetric logarithmic derivative of Fermionic Gaussian states. This provides a direct way of computing the quantum Fisher Information for Fermionic Gaussian states. Applications range from quantum Metrology with thermal states to non-equilibrium steady states with Fermionic many-body systems.

Navigation Patterns and Scent Marking: Underappreciated Contributors to Hippocampal and Entorhinal Spatial Representations?

According to the currently prevailing theory, hippocampal formation constructs and maintains cognitive spatial maps. Most of the experimental evidence for this theory comes from the studies on navigation in laboratory rats and mice, typically male animals. While these animals exhibit a rich repertoire of behaviors associated with navigation, including locomotion, head movements, whisking, sniffing, raring and scent marking, the contribution of these behavioral patterns to the hippocampal spatially-selective activity has not been sufficiently studied.

Light bullets in a time-delay model of a wide-aperture mode-locked semiconductor laser.

Recently, a mechanism of formation of light bullets (LBs) in wide-aperture passively mode-locked lasers was proposed. The conditions for existence and stability of these bullets, found in the long cavity limit, were studied theoretically under the mean field (MF) approximation using a Haus-type model equation. In this paper, we relax the MF approximation and study LB formation in a model of a wide-aperture three section laser with a long diffractive section and short absorber and gain sections.

Integrated Strategy for Lead Optimization Based on Fragment Growing: The Diversity-Oriented-Target-Focused-Synthesis Approach.

Over the past few decades, hit identification has been greatly facilitated by advances in high-throughput and fragment-based screenings. One major hurdle remaining in drug discovery is process automation of hit-to-lead (H2L) optimization. Here, we report a time- and cost-efficient integrated strategy for H2L optimization as well as a partially automated design of potent chemical probes consisting of a focused-chemical-library design and virtual screening coupled with robotic diversity-oriented de novo synthesis and automated in vitro evaluation.

Hormesis and paradoxical effects of pea (Pisum sativum L.) parameters upon exposure to formaldehyde in a wide range of doses.

Formaldehyde is a widespread pollutant of soil near roads including agricultural lands. Non-monotonic changes (hormesis and paradoxical effects) in chlorophyll (Ch) and carotenoid (Car) contents, the lipid peroxidation (LP) rate in plant leaves and growth parameters (GP) of plants can be caused by various pollutants. Hormesis is a biphasic dose-response phenomenon, characterised by low-dose stimulation and high-dose inhibition.

Enhancing Metastability by Dissipation and Driving in an Asymmetric Bistable Quantum System.

The stabilizing effect of quantum fluctuations on the escape process and the relaxation dynamics from a quantum metastable state are investigated. Specifically, the quantum dynamics of a multilevel bistable system coupled to a bosonic Ohmic thermal bath in strong dissipation regime is analyzed. The study is performed by a non-perturbative method based on the real-time path integral approach of the Feynman-Vernon influence functional.