The N-terminal autoinhibitory module of the A1 domain in von Willebrand factor stabilizes the mechanosensor catch bond.

The von Willebrand factor (VWF), by interacting with the circulatory system and platelets, harnesses hemodynamic forces to form hemostatic plugs or occlusive thrombi. The autoinhibitory modules (AIMs) flanking the VWF-A1 domain were found to contribute to its biomechanical activation. However, how AIM sequences regulate the VWF-A1 binding behavior is controversial and incompletely understood as their structures are currently unsolvable by crystallography.

carbon-supported titanium dioxide (ICS-TiO) as an electrode material for high performance supercapacitors.

Supercapacitors have attracted significant attention in the last few years as they have the capability to fulfill the demand for both power and energy density in many energy storage applications. In this study, an carbon-supported titanium oxide (ICS-TiO) electrode has been prepared using sucrose and TiO powder. The ICS-TiO powder was prepared by slipcasting, followed by the annealing of the TiO slurry.

Rhopalione kali sp. nov., first known epicaridean parasite on the Malaysian pinnotherid crab, Serenotheres besutensis (Serène, 1967).

Species of the bopyrid isopod genus Rhopalione Pérez, 1920, are parasites of Indo-West Pacific pinnotherid crabs. Unlike other bopyrid parasites of brachyurans that occupy the branchial chambers, however, species of Rhopalione (subfamily Pseudioninae) infest the abdominal cavity. Prior to the present study, four species of Rhopalione were recognized: R.

Crystal chemistry and single-phase synthesis of Gd substituted Co-Zn ferrite nanoparticles for enhanced magnetic properties.

Rare earth (RE) ions are known to improve the magnetic interactions in spinel ferrites if they are accommodated in the lattice, whereas the formation of a secondary phase leads to the degradation of the magnetic properties of materials. Therefore, it is necessary to solubilize the RE ions in a spinel lattice to get the most benefit. In this context, this work describes the synthesis of Co-Zn ferrite nanoparticles and the Gd doping effect on the tuning of their magnetic properties.

Surface Engineering and Design Strategy for Surface-Amorphized TiO@Graphene Hybrids for High Power Li-Ion Battery Electrodes.

provides unprecedented opportunities for altering and tuning material properties. Surface-amorphized TiO@graphene synthesized using a designed low temperature-phase transformation technique exhibits significantly improved rate capability compared to well-crystallized TiO@graphene and bare TiO electrodes. These improvements facilitates lithium-ion transport in both insertion and extraction processes and enhance electrolyte absorption capability.

Examination of narratives from emergency department presentations to identify road trauma, crash and injury risk factors for different age groups.

Background: Road trauma represents a high proportion of injury-related emergency department presentations. Narrative text recorded in the emergency department could provide useful information to monitor road trauma and to identify crash and injury risk factors by age group.

Objective: To examine the Public Health Real-time Emergency Department Surveillance System (PHREDSS) to identify road users (i.

Neuropsychiatry: where are we and where do we go from here?

Introduction: Neuropsychiatry has generally been regarded as a hybrid discipline that lies in the borderland between the disciplines of psychiatry and neurology. There is much debate on its current and future identity and status as a discipline.

Materials And Methods: Taking a historical perspective, the future of neuropsychiatry is placed within the context of recent developments in clinical neuroscience.

Keto-Functionalized Polymer Scaffolds As Versatile Precursors to Polymer Side Chain Conjugates.

A new methacrylate monomer with a reactive ketone side-chain, 2-(4-oxo-pentanoate) ethyl methacrylate (PAEMA), was synthesized and subsequently polymerized by reversible addition-fragmentation chain transfer (RAFT) polymerization to give a polymer with a narrow molecular weight distribution (PDI = 1.25). The polymer was chain extended with poly(ethylene glycol methyl ether acrylate) (PEGMA) to yield a block copolymer.