Simulation-based workshop for emergency preparedness in otolaryngology.

Objectives: This study aimed to evaluate the outcomes of a hands-on simulation-based course with emphasis on procedural techniques, clinical reasoning, and communication skills developed to improve junior Otolaryngology - Head and Neck Surgery (OHNS) residents' preparedness in managing otolaryngologic emergencies.

Methods: Junior OHNS residents and faculty from residency programs in California, Nevada, and Arizona participated in this workshop in 2020 and 2021. The stations featured airway management techniques, ultrasound-guided needle aspiration, nasoseptal hematoma evacuation, and facial fracture repair using various models and cadavers.

Comparative genomics of the T cell receptor μ locus in marsupials and monotremes.

T cells are a primary component of the vertebrate adaptive immune system. There are three mammalian T cell lineages based on their T cell receptors (TCR). The αβ T cells and γδ T cells are ancient and found broadly in vertebrates.

Competitive reversed quartet mechanisms for photogenerated ground state electron spin polarization.

Photoinduced electron spin polarization (ESP) of a spin-½ organic radical (nitronyl nitroxide, NN) in a series of Pt(ii) complexes comprised of 4,4'-di--butyl-2,2'-bipyridine (bpy) and 3--butylcatecholate (CAT) ligands, where the CAT ligand is substituted with (CH)--phenyl-NN (bridge-NN) groups, is presented and discussed. We show the importance of attenuating the energy gap between localized NN radical and chromophoric excited states to control both the magnitude and sign of the optically-generated ESP, and to provide deeper insight into the details of the ESP mechanism. Understanding electronic structure contributions to optically generated ESP will enhance our ability to control the nature of prepared states for a variety of quantum information science applications, where strong ESP facilitates enhanced sensitivity and readout capabilities at low applied magnetic fields and higher temperatures.

Blocking CCN2 Reduces Established Bone Loss Induced by Prolonged Intense Loading by Increasing Osteoblast Activity in Rats.

We have an operant model of reaching and grasping in which detrimental bone remodeling is observed rather than beneficial adaptation when rats perform a high-repetition, high-force (HRHF) task long term. Here, adult female Sprague-Dawley rats performed an intense HRHF task for 18 weeks, which we have shown induces radial trabecular bone osteopenia. One cohort was euthanized at this point (to assay the bone changes post task; HRHF-Untreated).

Evidence of differential phenotypic plasticity in a desert mustard.

Understanding the effect of the environment on trait variation is critical for ecologically and economically important plants. Here, we asked whether differences in soil moisture are a source of variation in Sahara mustard (). We subjected common garden populations of plants derived from native, invasive, and landrace sources (ranges) to varying water addition treatments.

 gen. nov. from South America described for two species previously in Régimbart, 1900 and two new species (Arthropoda, Insecta, Coleoptera, Adephaga, Dytiscidae, Hydroporinae, Bidessini).

is described for two previously described species, Guignot, 1955 from Colombia, with new records from Venezuela, and Gschwendtner, 1935, from Brazil, and two previously unknown species, , from Bolivia and Peru, and from Ecuador. The genus is characterized by 1) occipital line absent; 2) basal pronotal striae present; 3) basal elytral stria absent; 4) sutural elytral stria absent; 5) transverse carina on elytral epipleuron at humeral angle absent; 6) distinct marginal bead on anterior clypeal margin absent; and 7) male median lobe deeply multilobed with a dorsal portion separate from a unilobed or bilobed ventral portion.

Controlling the spacing of the linked graphene oxide system with dithiol linkers under confinement.

2D nanoscale confined systems exhibit behavior that is markedly different from that observed at the macroscale. Confinement can be tuned by controlling the interlayer spacing between confining layers using organic dithiol linkers. Adjusting spacing and selective intercalation have important impacts for catalysis, superconductivity, spin engineering, sodium ion batteries, 2D magnets, optoelectronics, and many other applications.

Photocrystallography of [Ru(bpy)(dmso)] reveals an O-bonded metastable state.

We report the first instance of observing the phototriggered isomerization of dmso ligands on a bis sulfoxide complex, [Ru(bpy)(dmso)], in the crystalline solid state. The solid-state UV-vis spectrum of the crystal demonstrates an increase in optical density around 550 nm after irradiation, which is consistent with the solution isomerization results. Digital images of the crystal before and after irradiation display a notable color change (pale orange to red) and cleavage occurs along planes, (1̄01) and (100), during irradiation.

From inequity to access: Evidence-based institutional practices to enhance care for individuals with disabilities.

People with disabilities experience barriers to care in all facets of health care, from engaging with the provider in a clinical setting (attitudinal and communication barriers) to navigating a large institution in a complex health care environment (organizational and environmental barriers), culminating in significant health care disparities. Institutional policy, culture, and physical layout may be inadvertently fostering ableism, which can perpetuate health care inaccessibility and health disparities in the disability community. Here, we present evidence-based interventions at the provider and institutional levels to accommodate patients with hearing, vision, and intellectual disabilities.

Race and sex demographics in the surgical management of facial nerve palsy.

Objective: Facial palsy affects patients of all backgrounds, yet no existing studies describe differences in its treatment patterns between demographic groups.

Methods: We used the National Surgical Quality Improvement Project database to investigate whether race and sex disparities exist in facial reanimation surgery. Patients were identified using CPT codes corresponding to facial-nerve procedures.

Modeling the relationship between gene expression and mutational signature.

Background: Mutational signatures computed from somatic mutations, allow an in-depth understanding of tumorigenesis and may illuminate early prevention strategies. Many studies have shown the regulation effects between somatic mutation and gene expression dysregulation.

Methods: We hypothesized that there are potential associations between mutational signature and gene expression.

A suggested data structure for transparent and repeatable reporting of bibliographic searching.

Academic searching is integral to research activities: (1) searching to retrieve specific information, (2) to expand our knowledge iteratively, (3) and to collate a representative and unbiased selection of the literature. Rigorous searching methods are vital for reliable, repeatable and unbiased searches needed for these second and third forms of searches (exploratory and systematic searching, respectively) that form a core part of evidence syntheses. Despite the broad awareness of the importance of transparency in reporting search activities in evidence syntheses, the importance of searching has been highlighted only recently and has been the explicit focus of reporting guidance (PRISMA-S).

Nineteen new species of Babington, 1841 (Coleoptera, Adephaga, Dytiscidae, Hydroporinae, Hyphydrini) with notes on the taxonomy of the genus.

Nineteen new species of Babington, 1841 are described from multiple species groups. Two new species groups are erected, the species group and the species group. (Venezuela), (Venezuela), (Suriname), and (Guyana) are described in but are not assigned to a species group.

Intracranial Hemorrhage Rate and Lesion Burden in Patients With Familial Cerebral Cavernous Malformation.

Background Familial cerebral cavernous alformation (CCM) is an autosomal dominant disease caused by mutations in , , or . Cases typically present with multiple lesions, strong family history, and neurological symptoms, including seizures, headaches, or other deficits. Intracranial hemorrhage (ICH) is a severe manifestation of CCM, which can lead to death or long-term neurological deficits.

A method for estimating and characterizing explicitly nonlinear dynamic functional network connectivity in resting-state fMRI data.

The past 10 years have seen an explosion of approaches that focus on the study of time-resolved change in functional connectivity (FC). FC characterization among networks at a whole-brain level is frequently termed functional network connectivity (FNC). Time-resolved or dynamic functional network connectivity (dFNC) focuses on the estimation of transient, recurring, whole-brain patterns of FNC.

Social and structural determinants of COVID-19 vaccine uptake among racial and ethnic groups.

Latino, Black, American Indian/Alaska Native (AI/AN), and Native Hawaiian or Other Pacific Islander people have the highest hospitalizations and death rates from COVID-19. Social inequalities have exacerbated COVID-19 related health disparities. This study examines social and structural determinants of COVID-19 vaccine uptake.

The Environmental Data Initiative: Connecting the past to the future through data reuse.

The Environmental Data Initiative (EDI) is a trustworthy, stable data repository, and data management support organization for the environmental scientist. In a bottom-up community process, EDI was built with the premise that freely and easily available data are necessary to advance the understanding of complex environmental processes and change, to improve transparency of research results, and to democratize ecological research. EDI provides tools and support that allow the environmental researcher to easily integrate data publishing into the research workflow.

MRI free water as a biomarker for cognitive performance: Validation in the MarkVCID consortium.

Introduction: To evaluate the clinical validity of free water (FW), a diffusion tensor imaging-based biomarker kit proposed by the MarkVCID consortium, by investigating the association between mean FW (mFW) and executive function.

Methods: Baseline mFW was related to a baseline composite measure of executive function (EFC), adjusting for relevant covariates, in three MarkVCID sub-cohorts, and replicated in five, large, independent legacy cohorts. In addition, we tested whether baseline mFW predicted accelerated EFC score decline (mean follow-up time: 1.

Cue polarization and representation in mouse home base behaviors.

The nature of the representation guiding spatial navigation has been investigated extensively; however, most of this work has used behavioral tasks that involved learning the location of food reward or an escape platform. In contrast, relatively few studies have focused on the spatial representation of a home base, a ubiquitous feature of open-field behavior, and its ability to be encoded relative to environmental cues. The current set of experiments investigated acquisition and retention of the location of home base establishment.

Treatment of hepatitis C in primary health care in the country of Georgia.

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