Health Care Perceptions and a Concierge-Based Transplant Evaluation for Patients With Kidney Disease.

Importance: The kidney transplant (KT) evaluation process is particularly time consuming and burdensome for Black patients, who report more discrimination, racism, and mistrust in health care than White patients. Whether alleviating patient burden in the KT evaluation process may improve perceptions of health care and enhance patients' experiences is important to understand.

Objective: To investigate whether Black and White participants would experience improvements in perceptions of health care after undergoing a streamlined, concierge-based approach to KT evaluation.

Effects of Integrating Palliative Care in Patients With Advanced Cancer: A Systematic Review and Meta-Analysis of Quality of Life and Psychological Outcomes.

Patients with advanced cancer frequently have a wide range of mental and physical symptoms, making it difficult for them to communicate and make informed decisions. Necessitating the incorporation of palliative care in this population to meet their supportive care requirements. To investigate the effects of integrating Palliative care in advanced cancer patients.

Strengthening Academic Public Health Programs and Workforce Development Through Fieldwork: Insights From a Novel Partnership Between New Mexico's Two Major Universities.

Our collaboration to strengthen applied practice in public health training between two public universities in New Mexico has offered us insight into the types of institutional, administrative, and programmatic support beneficial for navigating work with limited resources and varying geographic considerations. We share some lessons from this burgeoning partnership between University of New Mexico's (UNM) College of Population Health and New Mexico State University's (NMSU) Department of Public Health Sciences which began in 2022. The main areas of learning focus on exchanging resources to extend relationships with fieldwork sites and site supervisors, engage and support students in their planning and implementation of their fieldwork, and identify institutional resources to maintain and grow programmatic quality.

A giant planet transiting a 3-Myr protostar with a misaligned disk.

Astronomers have found more than a dozen planets transiting stars that are 10-40 million years old, but younger transiting planets have remained elusive. The lack of such discoveries may be because planets have not fully formed at this age or because our view is blocked by the protoplanetary disk. However, we now know that many outer disks are warped or broken; provided the inner disk is depleted, transiting planets may thus be visible.

Understanding the Carbyne Formation from CH Complexes.

Nature chooses a high-valent tungsten center at the active site of the enzyme acetylene hydratase to facilitate acetylene hydration to acetaldehyde. However, the reactions of tungsten-coordinated acetylene are still not well understood, which prevents the development of sustainable bioinspired alkyne hydration catalysts. Here we report the reactivity of two bioinspired tungsten complexes with the acetylene ligand acting as a four-: [W(CO)(CH)(PymS)] () and a two-electron donor: [WO(CH)(PymS)] (), with PMe as a nucleophile to simulate the enzyme's reactivity (PymS = 4-(trifluoromethyl)-6-methylpyrimidine-2-thiolate).

Accelerometer-Measured Volumes of Moderate-to-Vigorous Physical Activity and Functional Fitness in Older Adults.

The objective of this study is to investigate the association between different volumes of accelerometer-measured moderate-to-vigorous physical activity (MVPA) and functional fitness in older adults in a cross-sectional study (n = 242; 66 ± 5 years; 80% women). MVPA was assessed by accelerometer for 1 week. Based on the MVPA recommendations, the participants were classified as: (a) inactive (<50 min/week), (b) somewhat active (50-99 min/week), (c) moderately active (100-149 min/week), and (d) active (≥150 min/week).

Optimization of Timing for Risk-Reducing Salpingectomy and Oophorectomy.

ClinicalTrials.gov , NCT04251052.

Global screening of base excision repair in nucleosome core particles.

DNA damage is a fundamental molecular cause of genomic instability. Base excision repair (BER) is one line of defense to minimize the potential mutagenicity and/or toxicity derived from damaged nucleobase lesions. However, BER in the context of chromatin, in which eukaryotic genomic DNA is compacted through a hierarchy of DNA-histone protein interactions, is not fully understood.

A Survey of Dental Hygiene Pre-Clinic Instrumentation Selection and Sequence.

Objectives: The purpose of this study was to assess the selection and sequence of dental hygiene instruments taught during dental hygiene pre-clinical education in the United States.

Methods: Exempt status was received from the University of New Mexico's IRB (ID 21-336). A survey was developed with questions to be answered involving decisions for clinical teaching and sequencing on various assessment and implementation instruments during pre-clinic education.

Consensus Considerations and Good Practice Points for Use of Continuous Glucose Monitoring Systems in Hospital Settings.

Continuous glucose monitoring (CGM) systems provide frequent glucose measurements in interstitial fluid and have been used widely in ambulatory settings for diabetes management. During the coronavirus disease 2019 (COVID-19) pandemic, regulators in the U.S.

Molecular Dynamics Reveal Key Steps in BAR-Related Membrane Remodeling.

Endocytosis plays a complex role in pathogen-host interactions. It serves as a pathway for pathogens to enter the host cell and acts as a part of the immune defense mechanism. Endocytosis involves the formation of lipid membrane vesicles and the reshaping of the cell membrane, a task predominantly managed by proteins containing BAR (Bin1/Amphiphysin/yeast RVS167) domains.

Fuel-Driven π-Conjugated Superstructures to Form Transient Conductive Hydrogels.

Despite advances in creating dissipative materials with transient properties, such as hydrogels and active droplets, their application remains confined to temporal changes in structural properties. Developing out-of-equilibrium materials whose electronic functions are parameterized by a chemical reaction cycle is challenging. Yet, this class of materials is required to construct biomimetic materials.

Parent-implemented AAC verb symbol intervention with children with ASD.

A multiple-probe across participants design was used to examine whether three young children diagnosed with autism spectrum disorder (ASD) could learn to use verb symbols presented on an AAC application to request actions. Using researcher coaching (involving joint planning, descriptive instructions, and guided practice) parents of participants were taught to (a) embed opportunities for children to request actions in daily home routines, (b) model AAC responses, (c) use a prompt hierarchy with a time delay, and (d) contingently reinforce correct aided AAC responses. Following intervention delivered by parents, all three participants increased their use of verb symbols to request actions and parents implemented procedures with high fidelity.

Second-Coordination-Sphere Effects Reveal Electronic Structure Differences between the Mitochondrial Amidoxime Reducing Component and Sulfite Oxidase.

A combination of X-ray absorption and low-temperature electronic absorption spectroscopies has been used to probe the geometric and electronic structures of the human mitochondrial amidoxime reducing component enzyme (hmARC1) in the oxidized Mo(VI) and reduced Mo(IV) forms. Extended X-ray absorption fine structure analysis revealed that oxidized enzyme possesses a 5-coordinate [MoO(S)(PDT)] (PDT = pyranopterin dithiolene) active site with a cysteine coordinated to Mo. A 5-coordinate geometry is retained in the reduced state, with the equatorial oxo being protonated.

CSF proteomics identifies early changes in autosomal dominant Alzheimer's disease.

In this high-throughput proteomic study of autosomal dominant Alzheimer's disease (ADAD), we sought to identify early biomarkers in cerebrospinal fluid (CSF) for disease monitoring and treatment strategies. We examined CSF proteins in 286 mutation carriers (MCs) and 177 non-carriers (NCs). The developed multi-layer regression model distinguished proteins with different pseudo-trajectories between these groups.

Multitype Quantum Well Semiconductor Membrane External-Cavity Surface-Emitting Lasers for Widely Tunable Continuous Wave Operation.

Membrane external-cavity surface-emitting lasers (MECSELs) represent a cutting-edge approach in pushing the performance boundaries of vertically emitting semiconductor lasers. The fundamental concept of employing an extremely thin gain membrane, spanning from hundreds of nanometers to a few micrometers in thickness and sandwiched between transparent heat spreaders, introduces novel opportunities through uniform double-sided optical pumping and enhanced heat dissipation from the active region. Additionally, these advantages of MECSELs facilitate more intricate band gap engineering possibilities for the active region by integrating multiple types of quantum wells (QWs) into a single laser gain structure.

The impact of item order on the factor structure of the PTSD Checklist for DSM-5.

The PTSD Checklist for DSM-5 (PCL-5) is the most widely used self-report measure of posttraumatic stress disorder (PTSD) and is frequently modeled as having four correlated factors consistent with the DSM-5 symptom structure. Some researchers have argued that item order may influence factor structure. Although two studies have examined this, they were both based on DSM-IV criteria, and neither utilized a randomized design.

Phase 3 Trial of Cabozantinib to Treat Advanced Neuroendocrine Tumors.

Background: Treatment options for patients with advanced neuroendocrine tumors are limited. The efficacy of cabozantinib in the treatment of previously treated, progressive extrapancreatic or pancreatic neuroendocrine tumors is unclear.

Methods: We enrolled two independent cohorts of patients - those with extrapancreatic neuroendocrine tumors and those with pancreatic neuroendocrine tumors - who had received peptide receptor radionuclide therapy or targeted therapy or both.

COVID-19 Disease and Chronic Health Outcomes Associated with Nicotine Use in a Great Plains Tribal Community: A Community-Based Study.

Background: The Cheyenne River Sioux Tribe (CRST) is affected by high nicotine use and disease burden. Understanding nicotine exposure is important to recognize what groups may be at higher risk for negative health outcomes, including COVID-19.

Objective: To compare self-reported health outcomes and nicotine use between exclusive electronic cigarette (e-cig) users, users of combustible cigarettes, dual e-cig/cigarette users, and nonusers among adult residents on the CRST.