Meaningful benefit and minimal clinically important difference (MCID) in Alzheimer's disease: Open peer commentary.

Introduction: Approval of the anti-amyloid monoclonal antibodies has stimulated an important discussion of the value to be placed on the magnitude of slowing achieved by treatment compared to placebo.

Methods: The minimal clinically important difference (MCID) was reviewed in the context of other measures and analyses that provide perspective on the meaningfulness of treatment responses.

Results: TheMCID is a clinician-anchored approach to making this determination.

Who funds Alzheimer's disease drug development?

Introduction: Despite the increase in Alzheimer's disease (AD) cases in the United States, no new treatments have been approved in the United States since 2003. The costs associated with drug development programs are high and serve as a significant deterrent to AD therapeutic investigations. In this study, we analyze the sponsorship data for AD clinical trials conducted since 2016 to assess the fiscal support for AD clinical trials.

Electroactive Artificial Muscles Based on Functionally Antagonistic Core-Shell Polymer Electrolyte Derived from PS--PSS Block Copolymer.

Electroactive ionic soft actuators, a type of artificial muscles containing a polymer electrolyte membrane sandwiched between two electrodes, have been intensively investigated owing to their potential applications to bioinspired soft robotics, wearable electronics, and active biomedical devices. However, the design and synthesis of an efficient polymer electrolyte suitable for ion migration have been major challenges in developing high-performance ionic soft actuators. Herein, a highly bendable ionic soft actuator based on an unprecedented block copolymer is reported, i.

Electroionic Antagonistic Muscles Based on Nitrogen-Doped Carbons Derived from Poly(Triazine-Triptycene).

Electroactive soft actuators and bioinspired artificial muscles have received burgeoning interest as essential components in future electronic devices such as soft haptic-feedback systems, human-friendly wearable electronics, and active biomedical devices. However, important challenging issues including fast response time, ultralow input power, robust operation in harsh environments, high-resolution controllability, and cost-effectiveness remain to be resolved for more practical applications. Here, an electroionic antagonistic artificial muscle is reported based on hierarchically porous nitrogen-doped carbon (HPNC) electrodes derived from a microporous poly(triazine-triptycene) organic framework (PtztpOF).