22,355 results match your criteria: "University of Naples `Federico II'[Affiliation]"
Fitoterapia
January 2025
Department of Life Science, Health, and Health Professions, Link Campus University, 00165 Rome, Italy.
In this study have been evaluated the antiproliferative and antioxidant activities of Israeli Pulicaria incisa (Lam.) DC. essential oil (Pi1), of essential oil partially purified by xanthoxylin (Pi2), one of its feature metabolites, and the isolated xanthoxylin (Xan).
View Article and Find Full Text PDFCan J Cardiol
December 2024
Québec Heart & Lung Institute, Laval University, Québec City, Québec, Canada. Electronic address:
Background: Atrial fibrillation (AF) has been identified as a marker of advanced cardiac damage in aortic stenosis patients. However, the factors associated with poorer outcomes among AF patients in contemporary transcatheter aortic valve replacement (TAVR) practice, particularly regarding mortality and heart failure (HF)-related hospitalizations, remain largely unknown.
Methods: In this multicenter study we assessed consecutive patients with a history of AF and evaluated the clinical outcomes, predictors of mortality, and HF-related hospitalization rates of those who underwent TAVR with newer generation devices using either balloon- or self-expandable valves.
BJU Int
December 2024
Cancer Prognostics and Health Outcomes Unit, Division of Urology, University of Montréal Health Center, Montréal, QC, Canada.
Objectives: It is not known whether cancer-specific mortality (CSM) differences distinguish radical cystectomy (RC) from trimodal therapy (TMT) in octogenarians harbouring organ-confined (T2N0M0) urothelial cancer of the urinary bladder (UCUB).
Methods: Within the Surveillance, Epidemiology, and End Results database (2004-2021), CSM and other-cause mortality (OCM) rates were computed in octogenarian patients with organ-confined UCUB undergoing either TMT or RC. Smoothed cumulative incidence plots depicted 5-year CSM and OCM rates according to RC vs TMT.
Cell Host Microbe
December 2024
University of Naples Federico II, Department of Agricultural Sciences, Piazza Carlo di Borbone 1, 80055 Portici, Italy. Electronic address:
In this issue of Cell Host & Microbe, Peng et al. provide the MAGIC catalog as a resource for studying bacterial and viral diversity of the global gut microbiome in early life. By addressing gaps in geographic and age representation, this database enhances our understanding of early microbiome dynamics.
View Article and Find Full Text PDFJ Neurol
December 2024
Department of Advanced Medical and Surgery Science, Multiple Sclerosis Center, II Division of Neurology, University of Campania "L. Vanvitelli", 80131, Naples, Italy.
Arch Dermatol Res
December 2024
Section of Dermatology, Department of Clinical Medicine and Surgery, University of Naples Federico II, Napels, Italy.
Bimekizumab, is the most recent monoclonal antibody licensed for the management of moderate-to-severe plaque psoriasis, acting through the dual inhibition of interleukin (IL)-17 A and IL17F, setting it apart from other anti-IL17 biologics. To date, long-term data on the use of bimekizumab for the management of plaque psoriasis in a real-world setting are scant. The aim of our study was to evaluate the effectiveness and safety of bimekizumab in long-term.
View Article and Find Full Text PDFJ Am Coll Cardiol
December 2024
Department of Advanced Biomedical Sciences, University of Naples Federico II, Naples, Italy. Electronic address:
J Basic Clin Physiol Pharmacol
December 2024
Department of Neurosciences, Reproductive Sciences and Odontostomatology, University of Naples "Federico II", Naples, Italy.
Front Neurol
November 2024
Department of Maxillofacial Orthopaedics and Orthodontics, Pomeranian Medical University in Szczecin, Szczecin, Poland.
Background: Orthodontic treatment is frequently correlated with different levels of discomfort and pain, caused by the application of forces to move the teeth. The mechanism of orthodontic pain is based on the initially activation of sensory receptors in periodontal tissues which results in a cascade of nociceptive pain processing and transduction in both the central and peripheral nervous systems that is finally experienced by patients. The perception of pain is subjective and varies among people, as it is influenced by both general and individual elements.
View Article and Find Full Text PDFFront Immunol
December 2024
Department of Medicine, Surgery and Dentistry "Scuola Medica Salernitana", University of Salerno, Baronissi, Italy.
Introduction: Immune checkpoint inhibitor (ICI)-based immunotherapy targeting programmed cell death 1 (PD-1) or its ligand 1 (PD-L1) has radically changed the management of many types of solid tumors including non-small cell lung cancer (NSCLC). Many clinical trials have demonstrated that ICIs improve the survival and the quality of life of patients with advanced non oncogene NSCLC as compared to standard therapies. However, not all patients achieve a clinical benefit from this immunotherapeutic approach.
View Article and Find Full Text PDFJ Environ Manage
January 2025
University of the Balearic Islands/Instituto de Agroecología y Economía del Agua (INAGEA), Palma de Mallorca, Spain.
Unraveling the intricate spatial and temporal complexities of vegetation represents a crucial key to understanding ecosystem functioning. Drones, as cutting-edge technology, hold immense potential in bridging the gap between on-ground measurements and satellite remote sensing data. Nonetheless, a multitude of challenges still looms, with one of the foremost being the nuanced identification of scales that strike a balance between capturing maximum complexity while minimizing measurement errors.
View Article and Find Full Text PDFClin Genitourin Cancer
February 2025
Cancer Prognostics and Health Outcomes Unit, Division of Urology, University of Montréal Health Center, Montréal, Québec, Canada.
Purpose: Temporal trends in and predictors of inpatient palliative care use in patients with metastatic renal cell carcinoma (mRCC) undergoing critical care therapy are unknown.
Methods: Relying on the National Inpatient Sample (2008-2019), we identified mRCC patients undergoing critical care therapy, namely invasive mechanical ventilation, percutaneous endoscopic gastrostomy tube insertion, dialysis for acute kidney failure, total parenteral nutrition, or tracheostomy. Estimated annual percentage changes (EAPC) analyses and multivariable logistic regression models addressed inpatient palliative care use.
Ann Med
December 2025
Department of Clinical Medicine and Surgery, Section of Infectious Diseases, University of Naples "Federico II", Naples, Italy.
Background: Immunocompromised patients are at high risk of developing persisting/prolonged COVID-19. Data on the early combined use of antivirals and monoclonal antibodies in this population are scarce.
Research Design And Methods: We performed an observational, prospective study, enrolling immunocompromised outpatients with mild-to-moderate COVID-19, treated with a combination of sotrovimab plus one antiviral (remdesivir or nirmatrelvir/ritonavir) within 7 days from symptom onset.
J Craniofac Surg
December 2024
Maxillofacial Surgery Unit, Department of Neurosciences, Reproductive and Odontostomatological Sciences, University of Naples Federico II.
Utilizing data extracted from Scopus and Web of Science databases, all the publications comparing "Superficial Parotidectomy" AND "Extracapsular dissection" were considered. Original research, review articles, letters, and note articles were included. Data about publication frequency, language distribution, authorship patterns, co-occurrence of keywords, and citation counts were extracted.
View Article and Find Full Text PDFFront Pharmacol
November 2024
Systems Pharmacology and Translational Therapeutics Laboratory, at the Center for Advanced Studies and Technology (CAST), and Department of Neuroscience, Imaging and Clinical Science, "G. d'Annunzio" University, Chieti, Italy.
Background: PPARα and cyclooxygenase (COX)-2 are overexpressed in certain types of cancer. Thus, developing a dual inhibitor that targets both could be more effective as an anticancer agent than single inhibitors. We have previously shown that an analog of the bezafibrate named AA520 is a PPARα antagonist.
View Article and Find Full Text PDFInt J Dermatol
December 2024
Department of Clinical Medicine and Surgery, Section of Dermatology, University of Naples Federico II, Naples, Italy.
Disabil Rehabil
December 2024
Department of Experimental Medicine, University of Campania "Luigi Vanvitelli", Naples.
Objectives: To review the World Health Organization Disability Assessment Schedule (WHODAS2.0) application in elderly population.
Methods: A review of English articles was performed using the following databases: PubMed/Medline, Scopus, Web of Science, Cochrane, Embase.
Brain
December 2024
Neuromuscular and Neuroimmunology Unit, IRCCS Humanitas Research Hospital, 20089 Rozzano, Milan, Italy.
Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) often requires prolonged ongoing treatment to prevent worsening. The efficacy of rituximab in preventing worsening after the discontinuation of immunoglobulin therapy in CIDP patients was assessed. In this randomized, double-blind, placebo-controlled study, conducted at seven Italian hospitals, CIDP patients under immunoglobulin therapy were assigned to receive either rituximab (1g on days 1, 15, and 180±7) or placebo.
View Article and Find Full Text PDFFood Res Int
January 2025
Department of Agricultural Sciences, University of Naples Federico II, Portici, 80055 Naples, Italy. Electronic address:
Butyrate, a short-chain fatty acid, is a crucial product of gut microbial fermentation with significant implications for various metabolic and physiological processes. Dietary sources of butyrate are limited, primarily derived from the fermentation of dietary fibers by butyrate-producing gut bacteria. Butyrate exerts its effects primarily as a histone deacetylase (HDAC) inhibitor and through signaling pathways involving G protein-coupled receptors (GPCRs).
View Article and Find Full Text PDFClin Exp Dermatol
December 2024
Section of Dermatology, Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy.
Mol Biol Evol
December 2024
School of Plant Sciences and Food Security, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel.
Introns are highly prevalent in most eukaryotic genomes. Despite the accumulating evidence for benefits conferred by the possession of introns, their specific roles and functions, as well as the processes shaping their evolution, are still only partially understood. Here, we explore the evolution of the eukaryotic intron-exon gene structure by focusing on several key features such as the intron length, the number of introns, and the intron-to-exon length ratio in protein-coding genes.
View Article and Find Full Text PDFBiomed Pharmacother
December 2024
Department of Medicine and Surgery, University of Perugia, Perugia, Italy. Electronic address:
Int J Surg Case Rep
January 2025
Department of Advanced Biomedical Sciences, University of Naples Federico II, Naples, Italy; Breast Unit, University of Naples Federico II, Naples, Italy.
Introduction And Importance: Iatrogenic nerve injury is a possible complication of axillary lymph node dissection (ALND), which remains standard-of-care for some breast cancer patients. Recently, several studies have demonstrated that nerves auto-fluoresce in near-ultraviolet light (NUVL). We describe three women with BC in whom a recently-developed NUVL camera was used to facilitate visualization of and prevent iatrogenic injury to the intercostobrachial, long thoracic, and thoracodorsal nerves during ALND.
View Article and Find Full Text PDFAnn Surg Oncol
December 2024
Cancer Prognostics and Health Outcomes Unit, Division of Urology, University of Montréal Health Center, Montréal, QC, Canada.
Objective: This study aimed to compare adverse in-hospital outcomes in ileal conduit versus neobladder urinary diversion type after radical cystectomy (RC) in contemporary versus historical patients.
Methods: Patients were identified within the National Inpatient Sample (NIS 2000-2019). Propensity score matching (PSM; 1:2 ratio) and multivariable logistic regression models (LRMs) were used.