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Amiloride reduces portal hypertension in rat liver cirrhosis.

Gut

June 2010

Department of Medicine II (Gastroenterology and Hepatology), Liver Center Munich, University of Munich e Grosshadern, Munich 81377, Germany.

Objective: This study aimed to investigate the effect of amiloride on portal hypertension. Amiloride is known to inhibit Na(+)/H(+) exchangers on activated hepatic stellate cells.

Methods: Liver cirrhosis in rats was induced by bile duct ligation (BDL) or thioacetamide (TAA) administration.

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