5 results match your criteria: "University of Montreal and Centre Hospitalier Universitaire Sainte-Justine[Affiliation]"
Deficiency of ASGR1 in pigs recapitulates reduced risk factor for cardiovascular disease in humans.
PLoS Genet
November 2021
Key Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi, China.
Genetic variants in the asialoglycoprotein receptor 1 (ASGR1) are associated with a reduced risk of cardiovascular disease (CVD) in humans. However, the underlying molecular mechanism remains elusive. Given the cardiovascular similarities between pigs and humans, we generated ASGR1-deficient pigs using the CRISPR/Cas9 system.
View Article and Find Full Text PDFContemporary Role of Topical Calcineurin Inhibitors: A Pediatric Dermatology Perspective.
J Cutan Med Surg
February 2020
3 Department of Pediatrics, University of Calgary, AB, Canada.
Atopic dermatitis (AD) is the most common pediatric chronic inflammatory skin disease in North America, often involving complex treatment regimens and impairing the quality of life of affected children and their families. Two topical calcineurin inhibitors (TCIs) have been available for the treatment of AD in pediatric patients for more than 15 years, and they continue to represent an important steroid-sparing option for the management of AD. Despite the large body of evidence and extensive clinical experience with these agents, there remain concerns among parents and clinicians regarding the long-term safety of this class of therapy, particularly with respect to the boxed warning about the potential risk of lymphoma and malignancy associated with TCIs.
View Article and Find Full Text PDFGrowth hormone treatment of Canadian children: results from the GeNeSIS phase IV prospective observational study.
CMAJ Open
September 2018
University of Montreal and Centre hospitalier universitaire Sainte-Justine (Deal), Montréal, Que.; Lilly Research Laboratories (Kirsch), Toronto, Ont.; Endocrinology and Diabetes Unit (Chanoine), British Columbia Children's Hospital, Vancouver, BC; Division of Endocrinology and Metabolism (Lawrence), Children's Hospital of Eastern Ontario, Ottawa, Ont.; Division of Endocrinology (Cummings), IWK Health Centre, Dalhousie University, Halifax, NS; Division of Endocrinology (Rosolowsky), Department of Pediatrics, University of Alberta, Edmonton Clinic Health Academy, Edmonton, Alta.; Department of Pediatrics and Child Health (Marks), Children's Hospital Health Sciences Centre Winnipeg, University of Manitoba, Winnipeg, Man.; Lilly Research Laboratories (Jia), Indianapolis, Ind.; Eli Lilly and Company (Child), Windlesham, UK.
Background: Country-specific data on outcomes of treatment with recombinant human growth hormone are lacking. We present such data for children treated with growth hormone in Canada.
Methods: We describe characteristics and outcomes of 850 children (mean age at baseline 8.
Perioperative cerebral hemodynamics and oxygen metabolism in neonates with single-ventricle physiology.
Biomed Opt Express
December 2015
Fetal Neonatal Neuroimaging & Developmental Science Center, Division of Newborn Medicine, Boston Children's Hospital & Harvard Medical School, Boston, MA 02115, USA.
Congenital heart disease (CHD) patients are at risk for neurodevelopmental delay. The etiology of these delays is unclear, but abnormal prenatal cerebral maturation and postoperative hemodynamic instability likely play a role. A better understanding of these factors is needed to improve neurodevelopmental outcome.
View Article and Find Full Text PDFIncidence and Characteristics of Autoimmune Hepatitis.
Pediatrics
November 2015
University of Montreal and Centre Hospitalier Universitaire Sainte-Justine, Montreal, Quebec, Canada.
Background And Objectives: Autoimmune hepatitis (AIH) is a progressive inflammatory liver disease of unknown etiology, with limited population-based estimates of pediatric incidence. We reported the incidence of pediatric AIH in Canada and described its clinical characteristics.
Methods: We conducted a retrospective cohort study of patients aged <18 years diagnosed with AIH between 2000-2009 at all pediatric centers in Canada.