Gastroprotective Efficacy of North African Medicinal Plants: A Review on Their Therapeutic Potential for Peptic Ulcers.

Peptic ulcer disease remains a prevalent gastrointestinal disorder worldwide. Current treatments often have limitations, sparking interest in alternative therapies from medicinal plants. This review examines the gastroprotective potential of 54 North African medicinal plants against peptic ulcers.

Polyphenolic Profile and In vitro, In Silico Study of Stem Extracts from J. Maritimus (Juncaceae) Harvested from Eastern Algeria as Potential Anti-Inflammatory and Antioxidant Agents.

Juncus maritimusan extremophilous microorganism speciesknown for its medicinal properties was collected in the Biskra region with the aim of its valorization. The volume size of polyphenols, flavonoids and condensed tannins was performed using the Folin-Ciocalteu method, aluminum trichloride and vanillin respectively. The volume of Polyphenols was 127.

Synthesis, characterization, anticancer activity and molecular docking of metal complexes bearing a new Schiff base ligand.

2-(()-((4-((()-4-Nitrobenzylidene)amino)phenyl)imino)methyl)naphthalen-1-ol, was synthesised followed by metalation with Fe(III), Co(III), Cu(II), Zn(II) and Ni(II) metals. The compounds were characterised by different methods CHN, AAS, IR, NMR, XRD, TGA and UV-Vis. The results reveal that the ligand has bidentate behavior, and it is bound with metals by a coordination bond through both the nitrogen atom of the azomethine group and the oxygen atom, this provided an octahedral geometry.

Speed Estimation of Six-Phase Induction Motors, Using the Rotor Slot Harmonics.

Multiphase machines have recently been promoted as a viable alternative to traditional three-phase machines. Most experts are looking for strategies to estimate the rotation speed of such complex systems, since speed data are required for high-performance control purposes. Traditionally, electromechanical sensors were used to detect the rotor speed of electric motors.

Investigation of [H]diazepam derivatives as allosteric modulators of GABAA receptor αβγ subtypes: combination of molecular docking/dynamic simulations, pharmacokinetics/drug-likeness prediction, and QSAR analysis.

Unlabelled: In this paper, a data set of [H] diazepam derivatives was analyzed using various computational methods: molecular docking/dynamic simulations, and QSAR analysis. The main aims of these studies are to understand the binding mechanisms by which benzodiazepines allosterically modulate GABA receptor αβγ subtypes, from inducing neuronal inhibition at lower doses to the anesthetic effect at higher doses, and also, to define the structural requirements that contribute to improving the response of GABA/αβγ receptor to benzodiazepine drugs. The results of the molecular docking study allowed selecting Ro12-6377 and proflazepam as the best modulators for the four binding sites simultaneously.

: Phytochemical Profiling, Antioxidant and Antimicrobial Activity Using In Vitro and In Silico Studies.

() is a traditional plant that is popular for its richness in phenolic compounds and flavonoids. The aim of this study was to comprehensively investigate the phytochemical profile by liquid chromatography, electrospray ionization and tandem mass spectrometry (LC-ESI-MS), the mineral contents and the biological properties of methanol extract. contains significant amounts of phenolic compounds and flavonoids.

Effect of Extraction Methods on Polyphenols, Flavonoids, Mineral Elements, and Biological Activities of Essential Oil and Extracts of L.

Our study evaluated the in vitro antioxidant properties, antibacterial and antifungal activities, anti-inflammatory properties, and chemical composition of the essential oils (EOs), total phenol, and total flavonoid of wild L. This study also determined the mineral (nutritional and toxic) elements in the plant. The EOs were extracted using three techniques-hydro distillation (HD), steam distillation (SD), and microwave-assisted distillation (MAD)-and were analyzed using chromatography coupled with flame ionization (GC-FID) and gas chromatography attached with mass spectrometry detector (GC-MS).

An integrated and approach to determine the effects of three commonly used surfactants sodium dodecyl sulphate, cetylpyridinium chloride and sodium laureth sulphate on growth rate and hematology in .

The purpose of this work is to evaluate the homology modeling, prediction, and characterization of somatotropin and erythropoietin from as well as molecular docking and simulation experiments between the modeled proteins and surfactants sodium dodecyl sulfate (SDS), sodium laureth sulfate (SLES) and cetylpyridinium chloride (CPC). Using the best fit template structure, homology modeling of somatotropin and erythropoietin of respectively was conducted. The model structures were improved further with 3Drefine, and the final 3D structures were verified with PROCHEK, ERRATA and ProQ.