2,102 results match your criteria: "University of Missouri-St.Louis[Affiliation]"

Introduction: Physical Activity (PA) and its links to frailty, quality of life (QoL), and other comorbidities in older Ugandans living with HIV remain under-explored.

Methods: We analyzed data from three annual assessments of older people living with HIV (PLWH) and age- and sex-similar people not living with HIV (PnLWH). We fitted linear generalized estimating equations (GEE) regression models to estimate the correlates of PA, including demographics, frailty, QoL, HIV, and other comorbidities.

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Objective: Exposure to trauma and subsequent posttraumatic stress symptoms (PTSS) increase the risk of poor physical health outcomes. Yet, the nuances of the paths from trauma to poor health are largely theoretical, and research regarding how trauma types relate to specific trauma-related changes to diet and exercise is needed. The present study examined the associations between noninterpersonal and interpersonal trauma and PTSS with several novel dietary and exercise changes (i.

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The first five years of implementing Missouri's medication first approach to opioid use disorder treatment: Plateaus, regressions, and underbellies of progress.

J Subst Use Addict Treat

January 2025

University of Missouri-St. Louis, Addiction Science, Missouri Institute of Mental Health, 1 University Blvd., Benton Hall, Room 206, St. Louis, MO 63121, USA.

Introduction: Missouri's Medication First ("MedFirst") approach promotes same-day and long-term low-threshold access to medications for opioid use disorder (MOUD). Since 2017, Missouri's SAMHSA-funded State Targeted and State Opioid Response (STR/SOR) grants have supported MedFirst services (both medical and psychosocial) for uninsured individuals with opioid use disorder at state-contracted treatment programs. Though MedFirst demonstrated early success, results - with attention to possible racial disparities - must be revisited after five years of implementation.

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Mast seeding, the synchronous and highly variable production of seed crops by perennial plants, is a population-level phenomenon and has cascading effects in ecosystems. Mast seeding studies are typically conducted at the population/species level. Much less is known about synchrony in mast seeding between species because the necessary long-term data are rarely available.

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On August 9, 2014, Michael Brown was shot and killed by police officer Darren Wilson in Ferguson Missouri, sparking protests and civil unrest. Three studies have yielded inconsistent findings regarding the presence of posttraumatic stress symptoms (PTSSs) in the aftermath of the unrest in Ferguson. Additional work is needed to understand how exposure to community-level stressors may correspond with trauma-related outcomes, as well as accounting for knowledge of, and engagement in the events.

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Phosphatidic Acid Signaling in Modulating Plant Reproduction and Architecture.

Plant Commun

December 2024

Department of Biology, University of Missouri-St. Louis, St. Louis, MO 63121, USA; Donald Danforth Plant Science Center, St. Louis, MO 63132, USA. Electronic address:

Article Synopsis
  • Phosphatidic acid (PA) is a type of signaling lipid in plants that plays a crucial role in responding to environmental stresses and regulating key biological processes.
  • Research on mutants lacking PA's metabolizing enzymes and various analytical techniques has shown that PA is essential in various reproductive functions, including pollen tube development and seed formation.
  • The study will review these findings to better understand how PA influences plant reproduction and structure, while also suggesting areas for future research to further clarify its mechanisms of action.
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On the uniqueness of fern-insect interactions.

New Phytol

December 2024

Department of Biology and the Whitney R. Harris World Ecology Center, University of Missouri-St Louis, 1 University Boulevard, St Louis, MO, 63121-4499, USA.

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Background: First responders (law enforcement officers, emergency medical services, and firefighters) frequently interact with people who use drugs (PWUD). Based on the nature and outcomes of such encounters, these interactions have the potential either to reduce harm, or perpetuate it. Given increased funding and attention for first responder-led interventions involving PWUD, we must identify the most critical training for improving negative beliefs about these interventions and populations.

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The purpose of the current research study was to examine the relationship among Adverse Childhood Experiences (ACEs), racial discrimination, and internalizing problems (i.e., anxiety, depression) among Asian adolescents in the US.

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Recent Catalytic Applications of Ferrocene and Ferrocenium Cations in the Syntheses of Organic Compounds.

Molecules

November 2024

Department of Chemistry and Biochemistry, University of Missouri-St. Louis, One University Boulevard, St. Louis, MO 63121, USA.

Ferrocene and its oxidized counterpart, the ferrocenium cation, represent a fascinating class of organometallic compounds with broad utility across various fields, including organic synthesis, pharmaceuticals, and materials science. Over the years, ferrocene, ferrocenium cations, and their derivatives have also gained prominence for their versatility in catalytic processes. This review article offers an overview of the research of the last decade into ferrocene- and ferrocenium-based catalysis.

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Background: Chronic pain following traumatic stress exposure (TSE) is common. Increasing evidence suggests inflammatory/immune mechanisms are induced by TSE, play a key role in the recovery process versus development of post-TSE chronic pain, and are sex specific. In this study, we tested the hypothesis that the inflammatory marker C-reactive protein (CRP) is associated with chronic pain after TSE in a sex-specific manner.

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Plants display a range of temporal patterns of inter-annual reproduction, from relatively constant seed production to "mast seeding," the synchronized and highly variable interannual seed production of plants within a population. Previous efforts have compiled global records of seed production in long-lived plants to gain insight into seed production, forest and animal population dynamics, and the effects of global change on masting. Existing datasets focus on seed production dynamics at the population scale but are limited in their ability to examine community-level mast seeding dynamics across different plant species at the continental scale.

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Salinity gradients act as strong environmental barriers that limit the distribution of aquatic organisms. Changes in gene expression associated with transitions between freshwater and saltwater environments can provide insights into organismal responses to variation in salinity. We used RNA-sequencing (RNA-seq) to investigate genome-wide variation in gene expression between a hypersaline population and a freshwater population of the livebearing fish species Limia perugiae (Poeciliidae).

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Background: Mycobacterium abscessus is an emerging pathogen causing severe pulmonary infections, particularly in individuals with underlying conditions, such as cystic fibrosis or chronic obstructive pulmonary disease. Macrolides, such as clarithromycin (CLR) or azithromycin (AZM), represent the cornerstone of antibiotherapy against the M. abscessus species.

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Community violence (CV) is associated with negative psychosocial outcomes, such as posttraumatic stress symptoms (PTSS) and anger; however, many individuals also exhibit resilience. Considering the multifinality of outcomes following CV and guided by Bronfenbrenner's ecological systems framework, the current study sought to examine individual, microsystem, and exosystem level factors in relation to PTSS, anger, and resilience. Participants were 536 emerging adults ( = 20.

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Social Buffering of PTSD: Longitudinal Effects and Neural Mediators.

Biol Psychiatry Cogn Neurosci Neuroimaging

November 2024

Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, 30329, USA. Electronic address:

Article Synopsis
  • This study investigates how early social support after trauma affects PTSD symptoms over time and explores specific brain regions involved in this process, such as the amygdala and ventromedial prefrontal cortex.
  • Using data from 315 participants in the AURORA study, researchers measured PTSD symptoms and perceived emotional support at multiple time points, while also conducting neuroimaging two weeks post-trauma.
  • The results show that early emotional support is linked to changes in white matter connectivity between key brain areas, but it also highlighted unexpected increased threat reactivity in the default mode network, suggesting complex neural pathways in response to social threats.
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Recent developments in the photoredox catalyzed Minisci-type reactions under continuous flow.

Chem Commun (Camb)

December 2024

Department of Chemistry and Biochemistry, University of Missouri-St. Louis, One University Boulevard, St. Louis, MO 63121, USA.

Article Synopsis
  • The Minisci reaction is an effective method for directly modifying heterocyclic molecules through C-H functionalization, relying on radical chemistry.
  • It has gained popularity because its results are predictable based on the types of radicals and heterocycles used.
  • The review discusses recent strategies, particularly the use of continuous flow techniques, to scale up this reaction for drug development purposes.
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Prior Diagnoses and Age of Diagnosis in Children Later Diagnosed with Autism.

J Autism Dev Disord

November 2024

University of Missouri- St. Louis, 1 University Blvd, St. Louis, MO, 63121, USA.

Article Synopsis
  • - Awareness of autism is increasing, but social factors like race, sex, and location affect diagnosis age and frequency, revealing potential biases in the healthcare system.
  • - A study of 13,850 Missouri children diagnosed with autism showed that being White and having previous diagnoses correlated with older ages of autism diagnosis, while boys had a higher likelihood of ADHD.
  • - The research suggests that living in urban areas provides better access to healthcare, resulting in a trend of later autism diagnoses among White children, and highlights the need for further investigation into the barriers and impacts of previous diagnoses.
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Exploring Facets of Trust and Religiosity in Organ Donation for Black and White Americans.

J Relig Health

November 2024

Department of Communication and Media, University of Missouri-St. Louis, One University Blvd., 426 Woods Hall, St. Louis, MO, 63121, USA.

This study examines how Black and White Americans perceive two facets of trust (trust in medical doctor and trust in medical care for racial group) and two facets of religiosity (religious service attendance and religious norms regarding organ donation) in relation to the topic of organ donation. Two hundred and one participants (N = 201) were surveyed across the United States using the Qualtrics survey company. Bivariate analyses found donor status was not related to religious service attendance (r = - .

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Article Synopsis
  • - Irinotecan is an ineffective standalone treatment for colorectal cancer, but combining it with Metformin and oncolytic Reovirus-infected secretome shows promise in boosting anti-tumor activity.
  • - The study analyzed the effects of these combinations on murine colorectal cancer cells (CT26) and demonstrated significantly lower cell viability and higher apoptosis rates with the triple combination over other treatments.
  • - Results indicate that using Reovirus-infected secretome alongside Metformin and Irinotecan produces a stronger synergistic effect for inducing cancer cell death compared to other combinations tested.
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Article Synopsis
  • - The study explored the use of wrist-wearable devices to track heart rate variability (HRV) as potential biomarkers for recovery from adverse neuropsychiatric effects following traumatic events, specifically in a socioeconomically disadvantaged group.
  • - Researchers monitored participants within 72 hours of a traumatic event and over a course of 6 months, validating HRV characteristics linked to various posttraumatic symptoms, such as pain, re-experiencing, and anxiety.
  • - The findings indicate that changes in HRV could effectively predict improvements or worsening in symptoms, suggesting that these wearable technologies could serve as useful screening tools for identifying posttraumatic stress in high-risk populations.
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The establishment of the anther somatic niche with single-cell sequencing.

Dev Biol

February 2025

Department of Biology, Stanford University, Stanford, CA, 94305, USA. Electronic address:

The anther is the developmental housing of pollen and therefore the male gametes of flowering plants. The meiotic cells from which pollen are derived must differentiate de novo from somatic anther cells and synchronously develop with the rest of the anther. Anthropogenic control over another development has become crucial for global agriculture so as to maintain inbred lines and generate hybrid seeds of many crops.

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Article Synopsis
  • - The study investigates sex/gender differences in PTSD by examining 16 risk factors and their impact on PTSD severity in a group of 2,924 acutely traumatized individuals.
  • - It finds that six risk factors are more prevalent in women, while none are more pronounced in men, highlighting unique pathways contributing to PTSD severity based on sex assigned at birth.
  • - The results indicate different risk mechanisms for men and women, suggesting that understanding these differences can help develop targeted mental health interventions and inform future research on other mental disorders.
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Why Is It Too Cold? Towards a Mechanistic Understanding of Cold-Water Pollution Effects on Recruitment of an Imperiled Warmwater Fish.

Mol Ecol

January 2025

U.S. Fish and Wildlife Service, San Juan River Basin Recovery Implementation Program, Albuquerque, New Mexico, USA.

Environmental temperature shapes the ontogeny of ectotherms by influencing rates of growth and development which can be key determinants of survival. Whereas the escalating impacts of water management on freshwater ecosystems is well documented, the effects of cold-water releases from dams-which can alter downstream temperatures-remains relatively underexplored but may present novel challenges to endemic ectotherms. Specifically, little is known about how thermal depressions reshape phenotypic and genetic patterns during larval metamorphosis for fishes that evolved in warmwater systems.

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