Use of moment of inertia in comparative molecular field analysis to model chromatographic retention of nonpolar solutes.

A quantitative structure-retention relationship (QSRR) was developed from chromatographic data on 31 unsubstituted 3-6 ring polycyclic aromatic hydrocarbons (PAHs) using the 3D-QSAR method known as comparative molecular field analysis (CoMFA). The resulting CoMFA model gave an excellent correlation to high-performance liquid chromatography retention data for these PAHs yielding r2 values of 0.947 (conventional) and 0.

Outreach to homeless mentally ill people: conceptual and clinical considerations.

This paper describes a model of outreach predicated on developing a trusting, meaningful relationship between the outreach worker and the homeless person with mental illness. We describe five common tasks inherent in this model of outreach (establishing contact and credibility, identifying people with mental illness, engaging clients, conducting assessments and treatment planning, and providing ongoing service). Other issues discussed include: (a) Responding to dependency needs and promoting autonomy; (b) setting limits while maintaining flexibility; (c) resistance to mental health treatment and follow-up service options.

Chiral alpha -hydroxy acids: racemic 2-hydroxy-2,3,3-trimethylbutanoic acid and 2-hydroxy-2-trimethylsilylpropanoic acid.

Both C7H14O3 and C6H14O3Si crystallize as racemates from acetone solution, the former incorporating water of crystallization (C7H14O3.0.5H2O).

Time-management training: effects on time behaviors, attitudes, and job performance.

This quasi-experimental field study examined the effects of a time-management training program on 44 employees' self-reports of time-management behavior control over their time, job satisfaction, and stress responses, and on supervisor's ratings of these employees' job performance. Contrary to expectations, respondents did not report more frequent use of time-management behaviors, more job satisfaction, or less job-induced tension after training, compared with those not receiving training. Job performance did not significantly change after training.

Molecular modeling of substrate-enzyme reactions for the cysteine protease papain.

AM1 quantum mechanical reaction coordinate (RC) calculations were run to simulate the rate-limiting deacylation (hydrolysis) reaction for a series of para-X-PhC(O)NHCH2-C(Y)-S-papain intermediates, where X = OCH3, CH3, H, Cl, NO2 and Y = O (thioester) or S (dithioester), for which a large body of structural, kinetic, and spectroscopic data is available. Several reaction zones, in particular the so-designated Large Zone and Small Zone, were extracted for these RC simulations from the fully solvated and energy-minimized X-ray crystal structure of papain (pdb9pap) bound to the appropriate substrate moiety. The major structural difference between these two zones was the absence of the oxyanion hole in the latter.

Detecting abuse against women in the home.

Assault is the single major cause of injury to women. Between 1.8 and 4.

Visual-auditory integration in cat superior colliculus: implications for neuronal control of the orienting response.

Previous physiological studies have demonstrated that inputs from different sensory modalities converge on individual neurons in the superior colliculus. Moreover, in anesthetized, paralyzed animals, those tectal neurons which are most directly connected to brain stem circuits mediating orienting eye and head movements are highly likely to exhibit significant integration of sensory inputs from multiple modalities. The purpose of the present study was to examine the responses of tectal neurons in the alert cat when visual and auditory stimuli were presented as targets for ocular fixation and orienting responses.

A second nitrogenase in vegetative cells of a heterocyst-forming cyanobacterium.

In many filamentous cyanobacteria nitrogen fixation occurs in differentiated cells called heterocysts. Filamentous strains that do not form heterocysts may fix nitrogen in vegetative cells, primarily under anaerobic conditions. We describe here two functional Mo-dependent nitrogenases in a single organism, the cyanobacterium Anabaena variabilis.

Expression of the cell cycle control gene, cdc25, is constitutive in the segmental founder cells but is cell-cycle-regulated in the micromeres of leech embryos.

The identifiable cells of leech embryos exhibit characteristic differences in the timing of cell division. To elucidate the mechanisms underlying these cell-specific differences in cell cycle timing, the leech cdc25 gene was isolated because Cdc25 phosphatase regulates the asynchronous cell divisions of postblastoderm Drosophila embryos. Examination of the distribution of cdc25 RNA and the zygotic expression of cdc25 in identified cells of leech embryos revealed lineage-dependent mechanisms of regulation.

Corporate values as related to occupation, gender, age, and company size.

A mail survey was used to study the perceived importance of 15 corporate values among advertising personnel, CPAs, and business school professors. Excellent customer service, ethical behavior, and product quality were perceived as highly important by all groups. Political activity and contribution to the community were seen as relatively unimportant.

Characterization of nifB, nifS, and nifU genes in the cyanobacterium Anabaena variabilis: NifB is required for the vanadium-dependent nitrogenase.

Anabaena variabilis ATCC 29413 is a heterotrophic, nitrogen-fixing cyanobacterium containing both a Mo-dependent nitrogenase encoded by the nif genes and V-dependent nitrogenase encoded by the vnf genes. The nifB, nifS, and nifU genes of A. variabilis were cloned, mapped, and partially sequenced.

Quantitative synthesis and formation of cyclopenta[cd]pyrene 3,4-oxide under simulated atmospheric conditions.

Cyclopenta[cd]pyrene 3,4-oxide (2) has been synthesized in a one-step, quantitative reaction using dimethyldioxirane. The oxide, or its thermal rearrangement products cyclopenta[cd]-pyren-3(4H)-one and cyclopenta[cd]pyren-4(3H)-one, is formed from cyclopenta[cd]pyrene (1) under simulated environmental conditions. In one case these products are formed when 1 is adsorbed on model particulates and then exposed to the reaction products of tetramethylethylene and ozone in the gas phase.

Child abuse by the middle class? A study of professionals in India.

The purpose of this study was to determine if the abuse of children was prevalent among middle-class professionals in India. Face-to-face interviews were conducted with a stratified random sample of 319 subjects, in three cities in India, to assess their attitudes toward child rearing and their expectations about child development. These were then correlated with the methods of conflict resolution which had been used with children in the past year.

Vernier acuity and aging.

Purpose/background: Many visual functions change with age. Hyperacuity vernier thresholds, however, seem to remain practically invariant with age.

Methods: We critically review reports on age-related changes in hyperacuity thresholds and present new data using two and three-point vernier hyperacuity thresholds.

Effects of eye position on saccadic eye movements and on the neuronal responses to auditory and visual stimuli in cat superior colliculus.

Many neurons in the deeper layers of the superior colliculus (SC) respond to multiple sensory inputs--visual, auditory, and somatic--as well as provide signals essential for saccadic eye movements to targets in different modalities. When the eyes and pinnae are in primary position, the neural map of auditory space is in rough topographic alignment with the map of visual space, and if the auditory map is based solely on headpinna coordinates, any changes in eye position in the orbit will cause misalignment of the maps. We investigated the effects of eye position on the response of sound-sensitive neurons in the SC of cats because previous work on cats and on monkeys had suggested the possibility of species differences in the representation of auditory signals in the SC.

Conformational analysis of the lipophilic antifolate trimetrexate.

The conformational properties of the lipophilic antifolate trimetrexate (TMQ) were calculated and compared to the structurally-analogous prototypical antifolate methotrexate (MTX) using both empirical force-field and AM1 quantum mechanical methods. The conformational preferences of TMQ and MTX are diametrically opposed with respect to the bridge-system set of torsion angles tau 1, tau 2: TMQ prefers gauche, trans while MTX prefers approximately trans, gauche. These predictions are consistent with the observed crystal structures of TMQ (i.

Partner abuse against female nursing students.

Although nurses may have the necessary skills to plan care of clients in a variety of settings, experience and research demonstrate that nursing interventions with women victims of violence have been consistently inadequate. Of the 243 nursing students included in this study, 8% reported experiencing physical abuse, and 18.9% reported experiencing nonphysical abuse.

Detection of intrafamilial child abuse: children at intake at a children's observation home in India.

Cross-cultural studies have brought awareness that child abuse is a global problem. This study sought to assess whether the abuse of children by caregivers/parents is a phenomenon that is prevalent in Indian society, where social workers and other human service professionals traditionally have not been sensitive to its occurrence. Interviews with 515 children brought to a Children's Observation Home in Bombary resulted in self-reports of physical violence from approximately 50% of the sample, and of these, over two-thirds reported the use of abusive violence.

Chronic corticosterone treatment impairs spontaneous alternation behavior in rats.

The present study used behavioral and morphological measures to assess hippocampal integrity in adult male rats after 8 weeks of daily corticosterone (10 mg/kg) injections. Behavioral testing during the final week of treatment revealed that spontaneous alternation behavior, a behavioral marker of hippocampal damage, was reduced in experimental animals without influencing exploration. Physiological assessment indicated that steroid exposure produced functional changes characteristic of prolonged exposure to stress or elevated plasma corticosterone, i.

Compromises in the visual field with the M43 aviation mask.

This study evaluated peripheral vision through the M43 protective mask currently worn by aviators in the AH-64 Apache helicopter. A Humphrey Visual Field Analyzer was used to measure the sensitivity of a subject's visual field with and without the mask. The results were analyzed using Dicon's Fieldview software.

Dating scripts of gay men and lesbians.

Scripts for a first date for 51 gay men and 44 lesbians were explored. Well-defined scripts were found for both hypothetical and actual accounts. Hypothetical scripts contained fourteen actions for gay men and lesbians; eleven were common to both.