2 results match your criteria: "University of Missouri-St. Louis 1 University Blvd. St. Louis MO 63121 USA gokelg@umsl.edu.[Affiliation]"
Assessment of a host-guest interaction in a bilayer membrane model.
RSC Adv
November 2022
Chemistry & Biochemistry, University of Missouri-St. Louis 1 University Blvd. St. Louis MO 63121 USA
Supramolecular interactions are well recognized and many of them have been extensively studied in chemistry. The formation of supramolecular complexes that rely on weak force interactions are less well studied in bilayer membranes. Herein, a supported bilayer membrane is used to probe the penetration of a complex between tetracycline and a macrocyclic polyether.
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- Antimicrobial resistance is a growing global health issue, prompting the need for new antimicrobials that prevent bacterial resistance while remaining effective.
- Researchers have developed synthetic ionophores, called 'hydraphiles', which are designed to enhance ion transport and exhibit potent antibacterial properties.
- One specific hydraphile, benzyl C hydraphile (BCH), has been shown to significantly boost the efficacy of existing antibiotics against multi-drug resistant bacteria, while showing low toxicity and minimal resistance development.