Annual decline in β-cell function in patients with type 2 diabetes in China.

Background: The aim of this study was to investigate the annual decline of β-cell function correlated with disease duration in patients with type 2 diabetes in China.

Methods: This cross-sectional study included 4792 adults with type 2 diabetes who were recruited from four university hospital diabetes clinics between April 2018 and November 2018. Baseline data were collected from electric medical records.

Associations Between Psychological Profiles and Performance Success Among Professional Taekwondo Athletes in China: A Multidimensional Scaling Profile Analysis.

Sport psychology research has long sought to uncover the determinants of the optimal psychological state for peak performance. Persistent inquiries in this work include whether there is a set of ideal psychological and emotional factors that are required to achieve optimal performance and, if there are, what are they and how are they related to optimal performance. To answer these questions, the current study aimed to identify potential profiles of personality and emotional traits based on a sample of professional Taekwondo athletes from China.

Predictors of Attrition Among Young Children Receiving Trauma-Focused Therapy.

Findings from studies of predominately school-aged children indicate that few children complete trauma-focused treatment; however, researchers have not specifically examined risk factors for dropout among young trauma-exposed children. The purpose of the present study was to investigate risk factors for attrition among young children receiving trauma-focused therapy. Study participants were 189 treatment-seeking children aged 3-5 years (M = 4.

Sexual Behavior Problems and Premature Termination From Pediatric Trauma-Focused Treatment Among Sexually Abused Children.

Premature termination from child trauma-focused treatment is common; however, the role of children's level of symptoms as a risk factor for attrition remains uncertain. In particular, children's sexual behavior problems (SBPs) have received scant attention in the prior attrition literature, and no known studies to date have thoroughly examined SBPs in relation to premature treatment termination. The current study investigated whether higher levels of children's SBPs were associated with increased risk for attrition from trauma-focused treatment in a sample of 242 sexually abused children aged 2-12 years (M = 7.

'Makin' it' in the Heartland: Exploring perceptions of success among second-generation immigrant youth in St. Louis.

Introduction: Debates in the literature on youth transitions and on immigrant adaptation acknowledge that recent societal shifts have altered the conditions for young people growing up today. As a result, traditional notions of success may limit our understanding of the mechanisms that lead to differential transitional and adaptation pathways among today's children of immigrants. This study explores the definitions of success among a sample of Bosnian-origin youth in St.

Expanding Contraception Access for Women With Opioid-Use Disorder: A Qualitative Study of Opportunities and Challenges.

Purpose: As almost nine in ten pregnancies among women with opioid use disorder (OUD) are unintended, expanding access to contraception is an underutilized but potentially effective strategy in increasing reproductive agency and reducing the overall burden of neonatal abstinence syndrome. We aimed to identify where and how contraceptive services could be integrated into existing points-of-contact for women with OUD.

Approach: In-depth qualitative interviews.

Combined effects of gender affirmation and economic hardship on vulnerability to HIV: a qualitative analysis among U.S. adult transgender women.

Background: Transgender women ("trans women"), particularly African-American and Latina trans women, have disproportionately high prevalence of HIV in the United States (U.S.).

Not by associations alone: The role of contextual factors, individual differences, and propositional learning in the malleability of implicit alcohol attitudes.

Alcohol attitudes predict unique variance in drinking behavior and have been the target of manipulations and interventions to reduce high-risk alcohol use among youth and adults. However, whether these manipulations create long-lasting changes in alcohol-related attitudes and drinking behavior is unclear. The current mini-review focuses on evaluative conditioning (EC), a manipulation which pairs alcohol-related stimuli repeatedly with affectively valanced stimuli to create new semantic associations in memory; such associations underlie reflexive or impulsive behaviors like high-risk alcohol use.

Food security and health in transition to adulthood for individuals with disabilities.

Background: Due to a more stringent disability definition used for eligibility redetermination at age 18, individuals with disabilities may lose eligibility for the Supplement and Nutrition Assistance Program (SNAP).

Objective: This study examines how the transition to adulthood may affect the association between food security and self-rated health and healthcare needs for individuals with disabilities.

Methods: The study uses five years of data (2011-2015) from the National Health Interview Survey (NHIS).

Author Correction: Human and mouse single-nucleus transcriptomics reveal TREM2-dependent and TREM2-independent cellular responses in Alzheimer's disease.

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

Using machine learning to improve ensemble docking for drug discovery.

Ensemble docking has provided an inexpensive method to account for receptor flexibility in molecular docking for virtual screening. Unfortunately, as there is no rigorous theory to connect the docking scores from multiple structures to measured activity, researchers have not yet come up with effective ways to use these scores to classify compounds into actives and inactives. This shortcoming has led to the decrease, rather than an increase in the performance of classifying compounds when more structures are added to the ensemble.

Tropical tree size-frequency distributions from airborne lidar.

In tropical rainforests, tree size and number density are influenced by disturbance history, soil, topography, climate, and biological factors that are difficult to predict without detailed and widespread forest inventory data. Here, we quantify tree size-frequency distributions over an old-growth wet tropical forest at the La Selva Biological Station in Costa Rica by using an individual tree crown (ITC) algorithm on airborne lidar measurements. The ITC provided tree height, crown area, the number of trees >10 m height and, predicted tree diameter, and aboveground biomass from field allometry.

Word length negatively predicts recognition memory performance.

We examined how word length affects performance in three recognition memory experiments to resolve discrepant results in the literature for which there are theoretical implications. Shorter and longer words were equated on frequency, orthographic similarity, age of acquisition, and imageability. In Experiments 1 and 2, orthographic length (i.

Synthesis of Phosphonomethyl Tetrahydrofurans via the Mori-Tamaru Reaction of Phosphonodienes.

Nickel-catalyzed reductive addition of phosphonodienes to aldehydes (the Mori-Tamaru reaction) gives hydroxy vinyl phosphonates in good yields with excellent control of the relative stereochemistry. Base-induced cyclization of the vinyl phosphonates yields phosphonomethyl-substituted tetrahydrofurans. Inversion of the hydroxyl stereochemistry by Mitsunobu reaction and then cyclization yields a different set of phosphonomethyl-substituted tetrahydrofuran diastereoisomers.

How hospitals in mainland China responded to the outbreak of COVID-19 using information technology-enabled services: An analysis of hospital news webpages.

Objective: Many countries have implemented quarantine rules during the global outbreak of coronavirus disease 2019 (COVID-19). Understanding how hospitals can continue providing services in an effective manner under these circumstances is thus important. In this study, we investigate how information technology (IT) helped hospitals in mainland China better respond to the outbreak of the pandemic.

The effect of fearful expressions on recognition memory for faces: Behavioral and electrophysiological data.

Facial expressions affect memory for face identity. We tested how fearful expressions modulate recognition memory for faces. In two studies, participants completed a continuous recognition task with fearful and neutral faces while their electroencephalogram was recorded.

Correction to: Sex differences in 10-year ischemic cardiovascular disease risk prediction in Chinese patients with prediabetes and type 2 diabetes.

After the publication of the original article [1], we were notified that one of the corresponding author's name and her related institution were wrongly spelled.

Portable sequencing as a teaching tool in conservation and biodiversity research.

As biodiversity loss continues to accelerate, there is a critical need for education and biomonitoring across the globe. Portable technologies allow for in situ molecular biodiversity monitoring that has been historically out of reach for many researchers in habitat nations. In the realm of education, portable tools such as DNA sequencers facilitate in situ hands-on training in real-time sequencing and interpretation techniques.

The influence of breast cancer related lymphedema on women's return-to-work.

Background: Lymphedema is one of the major treatment complications following breast cancer surgery and radiation. As the majority of women who develop breast cancer are at the age of employment, occupational functioning and employment are issues of concern. This study is novel in exploring the ways that lymphedema affects their work experience.

The role of attention in the relationship between early life stress and depression.

Early life stress (ELS) can be very harmful to an individual's wellbeing and brain development. It is well established that childhood maltreatment is a significant risk factor for depression. ELS is positively correlated with depressive symptoms both in major depression disorder patients and healthy individuals, but the cognitive and neural mechanisms underlying this association are still unclear.

Gas-Phase Dissociation Chemistry of Deprotonated RGD.

We investigate the structure and dissociation pathways of the deprotonated amphoteric peptide arginylglycylasparic acid, [RGD-H]. We model the pertinent gas-phase structures and fragmentation chemistry of the precursor anions and predominant sequence-informative bond cleavages (, , and peaks) and compare these predictions to our tandem mass spectra and infrared spectroscopy experiments. Formation of the anions requires rate-limiting intramolecular back biting to cleave the second amide bond and generate an anhydride structure.

Floral reorientation: the restoration of pollination accuracy after accidents.

Plants sometimes suffer mechanical injury. The nonlethal collapse of a flowering stalk, for example, can greatly reduce plant fitness if it leads to 'incorrect' floral orientation and thus reduced visitation or poor pollination. When floral orientation is important for accurate pollination, as has been suggested for bilaterally symmetrical flowers, we predict that such flowers should have developmental and/or behavioural mechanisms for restoring 'correct' orientation after accidents.

Haemosporidian parasites of resident and wintering migratory birds in The Bahamas.

In temperate regions, some avian haemosporidian parasites have evolved seasonal transmission strategies, with chronic infections relapsing during spring and transmission peaking during the hosts' breeding season. Because lineages with seasonal transmission strategies are unlikely to produce gametocytes in winter, we predicted that (1) resident birds living within wintering areas of Neotropical migrants would unlikely be infected with North American parasite lineages; and (2) if infected, wintering migratory birds would be more likely to harbor Plasmodium spp. rather than Parahaemoproteus spp.