Abstinence Restores Cardiac Function in Mice with Established Alcohol-Induced Cardiomyopathy.

Alcohol-induced cardiomyopathy (ACM) has a poor prognosis with up to a 50% chance of death within four years of diagnosis. There are limited studies investigating the potential of abstinence for promoting repair after alcohol-induced cardiac damage, particularly in a controlled preclinical study design. Here, we developed an exposure protocol that led to significant decreases in cardiac function in C57BL6/J mice within 30 days; dP/dt max decreased in the mice fed alcohol for 30 days (8054 ± 664.

Systematic review of risk factors and outcomes of post-implantation syndrome following endovascular aortic repair.

Objective: Post implantation syndrome (PIS) is an early systemic inflammatory response following endovascular aortic repair (EVAR). The response is variable in patients and the clinical significance of PIS upon outcomes is unknown. This study aims to evaluate the incidence, risk factors, and prognostic implication of PIS.

I saw the Venetian blind sign.

The Venetian blind sign is a radiologic sign seen on pelvic ultrasound. It is classically associated with adenomyosis and, less commonly, uterine fibroids. It appears as alternating vertical stripes of hyperechoic and hypoechoic bands, resembling the horizontal slatted window blinds for which it is named.

Adipsin in the pathogenesis of cardiovascular diseases.

Adipsin is an adipokine predominantly synthesized in adipose tissues and released into circulation. It is also known as complement factor-D (CFD), acting as the rate-limiting factor in the alternative complement pathway and exerting essential functions on the activation of complement system. The deficiency of CFD in humans is a very rare condition.

Minimally Invasive Murine Laryngoscopy for Close-Up Imaging of Laryngeal Motion during Breathing and Swallowing.

The larynx is an essential organ in mammals with three primary functions - breathing, swallowing, and vocalizing. A wide range of disorders are known to impair laryngeal function, which results in difficulty breathing (dyspnea), swallowing impairment (dysphagia), and/or voice impairment (dysphonia). Dysphagia, in particular, can lead to aspiration pneumonia and associated morbidity, recurrent hospitalization, and early mortality.

The redox code of plants.

Central metabolism is organised through high-flux, Nicotinamide Adenine Dinucleotide (NAD/NADH) and NADP/NADPH systems operating at near equilibrium. As oxygen is indispensable for aerobic organisms, these systems are also linked to the levels of reactive oxygen species, such as HO, and through HO to the regulation of macromolecular structures and activities, via kinetically controlled sulphur switches in the redox proteome. Dynamic changes in HO production, scavenging and transport, associated with development, growth and responses to the environment are, therefore, linked to the redox state of the cell and regulate cellular function.

Randomized controlled trial of propranolol on social communication and anxiety in children and young adults with autism spectrum disorder.

Rationale: Autism spectrum disorder (ASD) is characterized by impaired social communication and is also frequently characterized by co-occurring anxiety. Propranolol is widely utilized to treat performance and public speaking anxiety. Single-dose psychopharmacological challenge studies suggested benefits using propranolol for verbal tasks and social interaction.

Advances in neuroproteomics for neurotrauma: unraveling insights for personalized medicine and future prospects.

Neuroproteomics, an emerging field at the intersection of neuroscience and proteomics, has garnered significant attention in the context of neurotrauma research. Neuroproteomics involves the quantitative and qualitative analysis of nervous system components, essential for understanding the dynamic events involved in the vast areas of neuroscience, including, but not limited to, neuropsychiatric disorders, neurodegenerative disorders, mental illness, traumatic brain injury, chronic traumatic encephalopathy, and other neurodegenerative diseases. With advancements in mass spectrometry coupled with bioinformatics and systems biology, neuroproteomics has led to the development of innovative techniques such as microproteomics, single-cell proteomics, and imaging mass spectrometry, which have significantly impacted neuronal biomarker research.

Predicting cognitive dysfunction and regional hubs using Braak staging amyloid-beta biomarkers and machine learning.

Mild cognitive impairment (MCI) is a transitional stage between normal aging and early Alzheimer's disease (AD). The presence of extracellular amyloid-beta (Aβ) in Braak regions suggests a connection with cognitive dysfunction in MCI/AD. Investigating the multivariate predictive relationships between regional Aβ biomarkers and cognitive function can aid in the early detection and prevention of AD.

Quantification of Phencyclidine (PCP) in Urine, Serum, or Plasma by Gas Chromatography-Mass Spectrometry (GC-MS).

Phencyclidine (PCP), a dissociative anesthetic, is a commonly abused recreational drug. In the 1950s, initially tested as an intravenous anesthetic, PCP was discontinued for clinical use due to its severe adverse effects. Since then, it has gained popularity as a recreational drug due to its ability to induce hallucinations and alter perception.

Quantification of Fentanyl and Norfentanyl in Whole Blood Using Liquid Chromatography-Tandem Mass Spectrometry.

Fentanyl is a synthetic opioid used in pain management with a potency 50-100 times that of morphine. Due to fentanyl's high potency, very low dosages are needed to elicit the desired response. Fentanyl is gaining popularity as a drug of abuse.

Comprehensive Urine Drug Screen by Gas Chromatography-Mass Spectrometry (GC-MS).

Drug screening is an important diagnostic tool in patient management and is an indispensable part of clinical toxicology laboratory services. While some laboratories employ automated chemistry analyzers for limited screening of drugs of abuse and a few common over-the-counter drugs, more comprehensive and detailed drug screening is needed for better patient care. Comprehensive drug screening generally involves immunoassays, colorimetric tests, and gas or liquid chromatography-mass spectrometry.

Serum and Urine Quantification of Delta-8 and Delta-9 Tetrahydrocannabinol Carboxylic Acid Using Gas Chromatography-Mass Spectrometry.

Marijuana is one of the most frequently used drugs in the United States. The major psychoactive ingredient of the marijuana plant is delta-9-tetrahydrocannabinol (Δ9-THC) with delta-8-tetrahydrocannabinol (Δ8-THC) also being a minor psychoactive ingredient. Marijuana has several clinical applications, but it is more notably used for recreational purposes.

Liquid Chromatography-Tandem Mass Spectrometry Method for the Quantification of Plasma Busulfan.

Busulfan is an alkylating agent and functions as a myeloablative and anti-leukemic chemotherapy drug. It is widely used with cyclophosphamide for conditioning patients undergoing bone marrow transplantation for myeloid leukemia. Studies have shown that the busulfan plasma concentration correlates better with clinical efficacy and toxicity than the patient's administered dosage.

Mass Spectrometry in Clinical Laboratory: Applications in Therapeutic Drug Monitoring and Toxicology.

Mass spectrometry (MS) coupled with liquid chromatography (LC) or gas chromatography (GC) has been proven to be a powerful platform in research and specialized clinical laboratories for decades. In clinical laboratories, it is used for compound identification and quantification. Due to the ability to provide specific identification, high sensitivity, and simultaneous analysis of multiple analytes (>100) in recent years, application of MS in routine clinical laboratories has increased significantly.