112 results match your criteria: "University of Missouri Research Reactor[Affiliation]"
Adv Sci (Weinh)
April 2022
Materials Science and Technology Division, Oak Ridge National Laboratory, Oak Ridge, TN, 37831, USA.
In magnetic systems, spin and exchange disorder can provide access to quantum criticality, frustration, and spin dynamics, but broad tunability of these responses and a deeper understanding of strong limit disorder are lacking. Here, it is demonstrated that high entropy oxides present a previously unexplored route to designing materials in which the presence of strong local compositional disorder may be exploited to generate tunable magnetic behaviors-from macroscopically ordered states to frustration-driven dynamic spin interactions. Single-crystal La(Cr Mn Fe Co Ni )O films are used as a model system hosting a magnetic sublattice with a high degree of microstate disorder in the form of site-to-site spin and exchange type inhomogeneity.
View Article and Find Full Text PDFInorg Chem
October 2021
Department of Medical Physics, University of Wisconsin, Madison, Wisconsin 53705, United States.
The therapeutic potential of the Meitner-Auger- and conversion-electron emitting radionuclide Sb remains unexplored because of the difficulty of incorporating it into biologically targeted compounds. To address this challenge, we report the development of Sb production from electroplated tin cyclotron targets and its complexation by a novel trithiol chelate. The chelation reaction occurs in harsh solvent conditions even in the presence of large quantities of tin, which are necessary for production on small, low energy (16 MeV) cyclotrons.
View Article and Find Full Text PDFMolecules
August 2021
University of Missouri Research Reactor, University of Missouri, Columbia, MO 65211, USA.
Chemokines and chemokine receptors have been recognized as critical signal components that maintain the physiological functions of various cells, particularly the immune cells. The signals of chemokines/chemokine receptors guide various leukocytes to respond to inflammatory reactions and infectious agents. Many chemokine receptors play supportive roles in the differentiation, proliferation, angiogenesis, and metastasis of diverse tumor cells.
View Article and Find Full Text PDFSci Rep
August 2021
Department of Radiology, Institute of Green Nanotechnology, University of Missouri, Columbia, MO, 65212, USA.
Men with castration-resistant prostate cancer (CRPC) face poor prognosis and increased risk of treatment-incurred adverse effects resulting in one of the highest mortalities among patient population globally. Immune cells act as double-edged sword depending on the tumor microenvironment, which leads to increased infiltration of pro-tumor (M2) macrophages. Development of new immunomodulatory therapeutic agents capable of targeting the tumor microenvironment, and hence orchestrating the transformation of pro-tumor M2 macrophages to anti-tumor M1, would substantially improve treatment outcomes of CRPC patients.
View Article and Find Full Text PDFAppl Radiat Isot
October 2021
Department of Chemistry, University of Missouri, Columbia, MO, 65211, USA. Electronic address:
Rhodium-105 (0.567 MeV β, 319 keV γ, 35.4 h half-life) was produced by neutron irradiation of enriched Ru (>99%) over multiple decades.
View Article and Find Full Text PDFJ Phys Condens Matter
July 2021
Department of Physics, 500 W. University Ave, University of Texas at El Paso, TX 79968, United States of America.
NaNiTeOhas a layered hexagonal structure with a honeycomb lattice constituted by Niand a chiral charge distribution of Nathat resides between the Ni layers. In the present work, the antiferromagnetic (AFM) transition temperature of NaNiTeOis confirmed at≈ 27 K, and further, it is found to be robust up to 8 T magnetic field and 1.2 GPa external pressure; and, without any frequency-dependence.
View Article and Find Full Text PDFPLoS One
October 2021
Department of Anthropology, University of Georgia, Athens, GA, United States of America.
Obsidian, originating from the Rocky Mountains and the West, was an exotic exchange commodity in Eastern North America that was often deposited in elaborate caches and burials associated with Middle Woodland era Hopewell and later complexes. In earlier times, obsidian is found only rarely. In this paper we report two obsidian flakes recovered from a now submerged paleolandscape beneath Lake Huron that are conclusively attributed to the Wagontire obsidian source in central Oregon; a distance of more than 4,000 km.
View Article and Find Full Text PDFNat Commun
February 2021
Ames Laboratory, Ames, IA, 50011, USA.
Knowledge of magnetic symmetry is vital for exploiting nontrivial surface states of magnetic topological materials. EuInAs is an excellent example, as it is predicted to have collinear antiferromagnetic order where the magnetic moment direction determines either a topological-crystalline-insulator phase supporting axion electrodynamics or a higher-order-topological-insulator phase with chiral hinge states. Here, we use neutron diffraction, symmetry analysis, and density functional theory results to demonstrate that EuInAs actually exhibits low-symmetry helical antiferromagnetic order which makes it a stoichiometric magnetic topological-crystalline axion insulator protected by the combination of a 180 rotation and time-reversal symmetries: [Formula: see text].
View Article and Find Full Text PDFAppl Radiat Isot
April 2021
University of Missouri - College of Engineering, 207 Naka Hall, Columbia, MO, 65211, USA; University of Missouri Research Reactor Center (MURR), 1513 Research Park Drive, Columbia, MO, 65211, USA.
This paper reports experimental results of a prototype titanium surface ionization source. For the first time, a lanthanide ion beam has been produced with a surface ionizer composed completely of titanium metal. Titanium does not readily activate with neutron irradiation.
View Article and Find Full Text PDFJ Med Chem
February 2021
Research Division, Harry S. Truman Memorial Veterans' Hospital, Research Service Room A005, 800 Hospital Drive, Columbia, Missouri 65201, United States.
In this study, we describe the development of heterobivalent [DUPA-6-Ahx-([In]In-DO3A)-8-Aoc-BBN ANT] and [DUPA-6-Ahx-([Lu]Lu-DO3A)-8-Aoc-BBN ANT] radiotracers that display very high selectivity/specificity for gastrin-releasing peptide receptor (GRPR)-/prostate-specific membrane antigen (PSMA)-expressing cells. These studies include metallation, purification, characterization, and in vitro and in vivo evaluation of the new small-molecule-/peptide-based radiopharmaceuticals having utility for imaging and potentially therapy. Competitive displacement binding assays using PC-3 cells and LNCaP cell membranes showed high binding affinity for the GRPR or the PSMA.
View Article and Find Full Text PDFJ Trace Elem Med Biol
March 2021
Department of Food and Nutrition, Yeungnam University, 280 Daehak-ro, Gyeongsan, Gyeongbuk, 38541, Republic of Korea. Electronic address:
Background: Although previous studies have shown that short-term exposure to mercury is associated with obesity, it should be noted that mercury is not easily released and that it constantly accumulates in the body. However, few studies have explored the association between chronic mercury exposure and obesity. This study aimed to examine the association between chronic mercury exposure and obesity in Korean adults.
View Article and Find Full Text PDFJ Phys Condens Matter
January 2021
Department of Physics, 500 W University Ave, University of Texas at El Paso, El Paso, TX 79968, United States of America.
We explored the electronic and magnetic properties of the lanthanide double perovskite DyFeCoO by combining magnetization, Raman and Mössbauer spectroscopy and neutron diffraction along with density functional theory (DFT) calculations. Our magnetization measurements revealed two magnetic phase transitions in DyFeCoO. First, a paramagnetic to antiferromagnetic transition at T = 248 K and subsequently, a spin reorientation transition at T = 86 K.
View Article and Find Full Text PDFSci Rep
October 2020
Department of Electrical Engineering and Computer Science, University of Missouri, Columbia, MO, 65201, USA.
High quality Ge doping of GaN is demonstrated using primarily thermal neutrons for the first time. In this study, GaN was doped with Ge to concentrations from 10 Ge atoms/cm to 10 Ge atoms/cm. The doping concentrations were measured using gamma-ray spectroscopy and confirmed using SIMS analysis.
View Article and Find Full Text PDFSci Adv
July 2020
Instituto Nacional de Antropología e Historia, Mexico City, DF, Mexico.
Investigations in the now-submerged cave systems on the Yucatán Peninsula continue to yield evidence for human presence during the Pleistocene-Holocene transition. Skeletal remains are scattered throughout the caves of Quintana Roo, most representing individuals who died in situ. The reasons why they explored these underground environments have remained unclear.
View Article and Find Full Text PDFMolecules
September 2020
University of Missouri Research Reactor, University of Missouri, Columbia, MO 65211-5110, USA.
Epinephrine (E) and norepinephrine (NE) play diverse roles in our body's physiology. In addition to their role in the peripheral nervous system (PNS), E/NE systems including their receptors are critical to the central nervous system (CNS) and to mental health. Various antipsychotics, antidepressants, and psychostimulants exert their influence partially through different subtypes of adrenergic receptors (ARs).
View Article and Find Full Text PDFInt J Cancer
February 2021
Diet, Genes, and Environment, Danish Cancer Society Research Center, Copenhagen, Denmark.
Low selenium status may be associated with increased risk of prostate cancer (PC), particularly aggressive PC, and variation in selenoprotein genes may constitute an important modifying factor. We aimed to investigate the association between two selenium status biomarkers [toenail selenium, plasma selenoprotein P (SELENOP)] and risk of advanced, high-grade and advanced-stage PC. We further studied whether variations in selenoprotein genes were associated with PC risk and selenium biomarker concentrations.
View Article and Find Full Text PDFSci Adv
July 2020
Peggy and Charles Stephenson Cancer Center, University of Oklahoma Health Science Center, Oklahoma City, OK 73104, USA.
Gene silencing using small-interfering RNA (siRNA) is a viable therapeutic approach; however, the lack of effective delivery systems limits its clinical translation. Herein, we doped conventional siRNA-liposomal formulations with gold nanoparticles to create "auroliposomes," which significantly enhanced gene silencing. We targeted MICU1, a novel glycolytic switch in ovarian cancer, and delivered MICU1-siRNA using three delivery systems-commercial transfection agents, conventional liposomes, and auroliposomes.
View Article and Find Full Text PDFInt J Nanomedicine
June 2020
Department of Pathology, The University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.
Int J Nanomedicine
May 2020
Department of Radiology, University of Missouri, Columbia, MO 65212, USA.
Purpose: The overarching objective of this investigation was to investigate the intervention of green nanotechnology to transform the ancient holistic Ayurvedic medicine scientifically credible through reproducible formulations and rigorous pre-clinical/clinical evaluations.
Methods: We provide, herein, full details: (i) on the discovery and full characterization of gold nanoparticles-based Nano Swarna Bhasma (henceforth referred to as NSB drug); (ii) In vitro anti-tumor properties of NSB drug in breast tumor cells; (iii) pre-clinical therapeutic efficacy studies of NSB drug in breast tumor bearing SCID mice through oral delivery protocols and (iv) first results of clinical translation, from mice to human breast cancer patients, through pilot human clinical trials, conducted according to the Ayurveda, Yoga and Naturopathy, Unani, Siddha and Homoeopathy (abbreviated as AYUSH) regulatory guidelines of the Government of India in metastatic breast cancer patients.
Results: The preclinical in vitro and in vivo investigations, in breast tumor bearing mice, established unequivocally that the NSB Nano-Ayurvedic medicine-gold nanoparticles-based drug is highly effective in controlling the growth of breast tumors in a dose dependent fashion in vivo.
Appl Radiat Isot
March 2020
Department of Chemistry, University of Missouri, Columbia, MO, 65211, USA; University of Missouri Research Reactor Center, 1513 Research Park Drive, Columbia, MO, 65211, USA.
The Facility for Rare Isotope Beams (FRIB) will generate many unique isotopes of scientific interest which are retained in the primary beam dump. This work uses Hollow Fiber Supported Liquid Membrane (HFSLM) for extraction of ultra-trace concentrations of short-lived radioisotopes from the large solution volumes present in the primary beam dump loop. Part per trillion levels of V were successfully recovered from an aqueous solution spiked with predicted concentrations of chemically similar species, with an extraction efficiency of 71% in 60 min.
View Article and Find Full Text PDFJ Alzheimers Dis
April 2021
Department of Internal Medicine, Rush University Medical Center, Chicago, IL, USA.
Background: Bromine is a naturally occurring element that is widely present in the human environment in various chemical forms primarily as flame retardants, pesticides, and water treatments.
Objective: In this exploratory study, we investigated the association of brain bromine concentrations on Alzheimer's disease (AD) neuropathology, cerebral infarcts, and Lewy bodies.
Methods: The study was conducted in 215 deceased participants of the Memory and Aging Project, a clinical-pathologic cohort study.
Sci Rep
November 2019
Electron Microscopy Core, University of Missouri, Columbia, MO, 65211, USA.
Red mineral pigment use is recognized as a fundamental component of a series of traits associated with human evolutionary development, social interaction, and behavioral complexity. Iron-enriched mineral deposits have been collected and prepared as pigment for use in rock art, personal adornment, and mortuary practices for millennia, yet little is known about early developments in mineral processing techniques in North America. Microanalysis of rock art pigments from the North American Pacific Northwest reveals a sophisticated use of iron oxide produced by the biomineralizing bacterium Leptothrix ochracea; a keystone species of chemolithotroph recognized in recent advances in the development of thermostable, colorfast biomaterial pigments.
View Article and Find Full Text PDFACS Omega
November 2019
Department of Physics and Astronomy and University of Missouri Research Reactor, University of Missouri, Columbia, Missouri 65211, United States.
We have investigated adsorption-induced deformation in graphene oxide framework materials (GOFs) using neutron diffraction at sample pressures up to 140 bar. GOFs, made by the solvothermal reaction of graphite oxide and benzene-1,4-diboronic acid, are a suitable candidate for deformation studies due to their narrow (∼1 nm), monodispersed, slit-shaped pores whose width can be measured by diffraction techniques. We have observed, in situ, a monotonic expansion of the slit width with increasing pressure upon adsorption of xenon, methane, and hydrogen under supercritical conditions.
View Article and Find Full Text PDFInt J Nanomedicine
October 2019
Institute of Green Nanotechnology, University of Missouri, Columbia, MO 65211, USA.
As part of our continuing quest to enhance the efficacy of bioactive phytochemicals in cancer therapy, we report an innovative green nanotechnology approach toward the use of resveratrol for the production of biocompatible resveratrol-conjugated gold nanoparticles (Res-AuNPs). Our overarching aim is to exploit the inherent pro-apoptotic properties of gold nanoparticles (AuNPs) through synergistic anti-tumor characteristics of resveratrol, with the aim of developing a new class of green nanotechnology-based phytochemical-embedded AuNPs for applications in oncology. Resveratrol was used to reduce Au to Au for the synthesis of Res-AuNPs at room temperature and gum arabic (GA) was used to further encapsulate the nanoparticulate surface to increase the overall stability of the AuNPs.
View Article and Find Full Text PDFThis data article contains archaeological context information and paste compositional data from 66 pottery sherds collected at seven archaeological sites in the Manialtepec Basin on the Pacific coast of Oaxaca, Mexico. The data include maps showing collection locations, a drawing of one archaeological profile, photographs of sherds, and compositional data produced by Instrumental Neutron Activation Analysis at the University of Missouri Research Reactor (MURR). The NAA data include a tabulation of principal components, data from log-based cluster analyses and compositional group defining discriminant analyses.
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