LIM kinases in cardiovascular health and disease.

The Lim Kinase (LIMK) family of serine/threonine kinases is comprised of LIMK1 and LIMK2, which are central regulators of cytoskeletal dynamics via their well-characterized roles in promoting actin polymerization and destabilizing the cellular microtubular network. The LIMKs have been demonstrated to modulate several fundamental physiological processes, including cell cycle progression, cell motility and migration, and cell differentiation. These processes play important roles in maintaining cardiovascular health.

Impact of Artificial Intelligence on Polyp Size and Surveillance Colonoscopy: A Phantom Study.

Background Artificial intelligence (AI) is a hot topic in the world of medicine. AI may be useful in identifying and sizing polyps, which influence surveillance intervals. Therefore, we examined polyp size estimation by AI using a survey study.

Multifunctional Porous Soft Composites for Bimodal Wearable Cardiac Monitors.

Wearable heart monitors are crucial for early diagnosis and treatment of heart diseases in non-clinical settings. However, their long-term applications require skin-interfaced materials that are ultrasoft, breathable, antibacterial, and possess robust, enduring on-skin adherence-features that remain elusive. Here, we have developed multifunctional porous soft composites that meet all these criteria for skin-interfaced bimodal cardiac monitoring.

Framing resilience linked to parental ethnic-racial socialization as hidden: A hidden resilience conceptual framework.

Parental ethnic-racial socialization is a source of adolescents' resilience against ethnic-racial discrimination. Recent meta-analyses have documented the aspects of ethnic-racial socialization (i.e.

Preparation of Bone Patellar Tendon Bone Allograft With Biocomposite Scaffold Augmentation.

Anterior cruciate ligament (ACL) injuries and subsequent surgical reconstruction are exceedingly common orthopaedic procedures. Surgical technique and graft preparation techniques continue to evolve as surgeons seek to increase surgical outcomes and decrease recovery time. As such, there is significant interest in identifying tools and techniques that may enhance the surgical process for patients undergoing an ACL reconstruction.

A Bedside-to-Bench-to-Bedside Journey to Advance Osteochondral Allograft Transplantation towards Biologic Joint Restoration.

More than 70 million adults in the United States are impacted by osteoarthritis (OA). Symptomatic articular cartilage loss that progresses to debilitating OA is being diagnosed more frequently and earlier in life, such that a growing number of active patients are faced with life-altering healthcare decisions at increasingly younger ages. Joint replacement surgeries, in the form of various artificial arthroplasties, are reliable operations, especially for older (>65 years), more sedentary patients with end-stage OA, but have major limitations for younger, more active patients.

Advancing Psychedelic-Assisted Therapy in Missouri (MO-PAT): Innovation at the Speed of Safety.

The United States is facing a growing behavioral health crisis. Now more than ever, novel, safe and effective treatments are needed. Over the past decade, clinical trials of psychedelic-assisted psychotherapies (PAT) have shown promising results for treating a number of common behavioral health conditions with minimal adverse effects.

Glucagon Like Peptide -1 Receptor Agonists for Weight Loss: A Primary Care Perspective.

In this article we review the glucagon like peptide -1 receptor agonist (GLP-1) medications and discuss how to approach using them for weight loss and management in non-diabetic patients.

Revival of a Beast: The Challenges Facing the Management and Control of Syphilis in Missouri from 2000 to 2024.

Syphilis is an old disease that remains to be a major threat in the modern world. In the last decade, we have seen an exponential rise in the number of new cases. While this surge is universal, some places appear to be more affected than others, such as the southern and midwestern states in the United States.

Leveraging artificial intelligence and machine learning to accelerate discovery of disease-modifying therapies in type 1 diabetes.

Progress in developing therapies for the maintenance of endogenous insulin secretion in, or the prevention of, type 1 diabetes has been hindered by limited animal models, the length and cost of clinical trials, difficulties in identifying individuals who will progress faster to a clinical diagnosis of type 1 diabetes, and heterogeneous clinical responses in intervention trials. Classic placebo-controlled intervention trials often include monotherapies, broad participant populations and extended follow-up periods focused on clinical endpoints. While this approach remains the 'gold standard' of clinical research, efforts are underway to implement new approaches harnessing the power of artificial intelligence and machine learning to accelerate drug discovery and efficacy testing.

Comparative evaluation of a novel [F] F-Labeled PET tracer XTR004 against [N] ammonia in myocardial perfusion imaging for coronary artery disease.

Aims: This study aimed to evaluate image quality, myocardial perfusion, and diagnostic performance of a novel [F]F-labeled PET tracer, XTR004 PET, myocardial perfusion imaging (MPI) compared with [N]Ammonia (NH) PET MPI.

Methods And Results: Forty-seven patients with suspected or known coronary artery disease (CAD) were prospectively enrolled to undergo one-day rest/ATP-stress XTR004 and NH electrocardiograph-gated PET imaging within 2 weeks. Among them, twenty-six patients underwent invasive coronary angiography (ICA), and nineteen were identified with flow-limited CAD (stenosis ≥ 70%).

Building a FAIR data ecosystem for incorporating single-cell transcriptomics data into agricultural genome to phenome research.

Introduction: The agriculture genomics community has numerous data submission standards available, but the standards for describing and storing single-cell (SC, e.g., scRNA- seq) data are comparatively underdeveloped.

A Study of Alkene Disulfonoxylation.

We have developed convenient protocols for alkene disulfonoxylation, which involve stirring alkene substrate with a commercial I(III) oxidant and sulfonic acid in CHCl at ambient temperature. The reactions can be performed open to air without any special precautions to exclude moisture and, in most cases, deliver the products of vicinal disulfonoxylation. Where relevant, the reactions are stereospecific and furnish the products of -disulfonoxylation.

Profiles of principal stress and coping: Concurrent and prospective correlates.

This study utilized latent profile analysis (LPA) to examine patterns of principal stress and coping and its relations with principal (n = 125), teacher (n = 3671), and student (n = 19,390) outcomes. LPA analysis of school principals based on their reports of stress and coping showed that most principals were classified as having high stress and high coping (74%) whereas 19% of principals were classified as high stress and low coping. Only a small percentage of principals (7%) were characterized by low stress and high coping.

Interaction between time-of-day and oxytocin efficacy in mice and humans with and without gestational diabetes.

Management of labor in women with diabetes is challenging due to the high risk of peri- and postpartum complications. To avoid cesarean section and assist with labor progression, Pitocin, a synthetic oxytocin, is frequently used to induce and augment labor. However, the efficacy of Pitocin is often compromised in diabetic pregnancies, leading to increased cesarian delivery.

Docking strategies for predicting protein-ligand interactions and their application to structure-based drug design.

Molecular docking stands as a pivotal element in the realm of computer-aided drug design (CADD), consistently contributing to advancements in pharmaceutical research. In essence, it employs computer algorithms to identify the "best" match between two molecules, akin to solving intricate three-dimensional jigsaw puzzles. At a more stringent level, the molecular docking challenge entails predicting the accurate bound association state based on the atomic coordinates of two molecules.

Soybean genomics research community strategic plan: A vision for 2024-2028.

This strategic plan summarizes the major accomplishments achieved in the last quinquennial by the soybean [Glycine max (L.) Merr.] genetics and genomics research community and outlines key priorities for the next 5 years (2024-2028).

Minute virus of mice NS1 redirects casein kinase 2 specificity to suppress the ATR DNA damage response pathway during infection.

Unlabelled: During infection the autonomous parvovirus minute virus of mice (MVM) generates extensive DNA damage which facilitates virus replication and induces a cellular DNA damage response (DDR) driven by the ataxia telangiectasia mutated (ATM) kinase. Atypically, the ataxia telangiectasia and Rad-3-related (ATR) DDR pathway remains inactive. Upon DNA damage ATR is normally recruited to single-stranded DNA sequences formed at genomic DNA damage sites, and while within a multiprotein complex activates, via phosphorylation, the key DDR regulator checkpoint kinase 1 (Chk1).

Inactivation of checkpoint kinase 1 (Chk1) during parvovirus minute virus of mice (MVM) infection inhibits cellular homologous recombination repair and facilitates viral genome replication.

During infection, the autonomous parvovirus minute virus of mice (MVM) induces cellular DNA breaks and localizes to such sites, which presumably affords an environment beneficial for genome replication. MVM replication also benefits from the DNA damage response (DDR) mediated by the ataxia-telangiectasia mutated (ATM) kinase, while the ataxia telangiectasia and Rad-3 related (ATR) arm of the DDR is disabled, which prevents activation of its primary target, checkpoint kinase 1 (Chk1). We find here that Chk1 inactivation strongly correlates with dephosphorylation of one of its targets, RAD51, known to play a pivotal role in homologous recombination repair (HRR), thus leading to substantial inhibition of DNA repair in infected cells.

Facilitators and Barriers to Integrating Patient-Generated Blood Pressure Data into Primary Care EHR Workflows.

Background:  Evidence supports using patient-generated blood pressure data for better outcomes in hypertension management. However, obstacles like dealing with home-generated paper data sets and questions of validity slowed the meaningful incorporation of home blood pressure into clinical care. As clinicians value patient data more, reliance on digital health solutions for data collection and shared decision-making grows.

Deciphering glioblastoma: Unveiling imaging markers for predicting MGMT promoter methylation status.

Glioblastoma, the most common primary malignant tumor of the central nervous system in adults, is also among the most lethal. Despite a comprehensive treatment approach which utilizes surgery and postoperative chemoradiation, prognosis typically remains dismal. However certain epigenetic modifications, such as methylation of the MGMT promoter, have been proven to correlate with improved post-treatment outcomes.