2 results match your criteria: "University of Minnesota Medical School and The University of Minnesota Amplatz Children's Hospital[Affiliation]"
Urinary desmosine: a biomarker of structural lung injury during CF pulmonary exacerbation.
Pediatr Pulmonol
September 2012
Department of Pediatrics, University of Minnesota Medical School and The University of Minnesota Amplatz Children's Hospital, Minneapolis, Minnesota 55455, USA.
Rationale: Cystic fibrosis (CF) lung disease is characterized by structural changes and remodeling in airway architecture and lung parenchyma. Neutrophilic inflammation and infection lead to injury and breakdown of airway matrix constituents, including elastin. The non-invasive measurement of urinary desmosine (UDes), a breakdown product of elastin, may be reflective of ongoing lung injury and may serve as a biomarker of active short-term damage during pulmonary exacerbation.
View Article and Find Full Text PDFSputum desmosine during hospital admission for pulmonary exacerbation in cystic fibrosis.
Chest
December 2009
Department of Pediatrics, University of Colorado School of Medicine, Aurora, CO; Mike McMorris Cystic Fibrosis Research and Treatment Center, the Children's Hospital, Aurora, CO.
Background: Cystic fibrosis (CF) lung disease is characterized by structural changes in the airways and parenchyma. No sputum biomarker exists to measure the degree of active structural destruction during pulmonary exacerbation in patients with CF. The noninvasive measurement of desmosine, a breakdown product of elastin, may reflect ongoing lung injury and serve as a biomarker of short-term damage.
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