Intravenous delivery of cysteamine for the treatment of cystinosis: association with hepatotoxicity.

Nephropathic cystinosis is a lysosomal storage disorder, which, if untreated, results in renal failure by age 10 years. Oral cysteamine has been shown to preserve renal function in these patients. In this study, a 2-year-old girl with nephropathic cystinosis and severe gastrointestinal dysmotility was treated with intravenous (i.

Implementation and case-study results of potentially better practices to improve the discharge process in the neonatal intensive care unit.

Objective: The objective of this study was to implement potentially better practices for discharge planning in the NICU.

Methods: Each participating hospital completed a self-assessment tool on discharge planning and a staff satisfaction survey. Parent satisfaction data were obtained from an Internet-based survey.

Mycobacterium bovis disease in a pediatric renal transplant patient.

We describe a pediatric renal transplant patient with Mycobacterium bovis disease who was successfully treated using an antituberculosis regimen that included rifampin. We discuss the history of M. bovis and the diagnosis and management of M.

Obesity in children: epidemic and opportunity.

Obesity has become widespread among both adults and children in the United States, with the prevalence of overweight and obese children increasing from 15% in 1971 to more than 30% in 2000. This article discusses how to determine whether a child is overweight or obese, the causes of childhood obesity, as well as how physicians can treat this disease using family-based diet, exercise, and behavior modification programs; weight-loss medications; protein-sparing modified fasting; and bariatric surgery.

Nonprimate models of congenital cytomegalovirus (CMV) infection: gaining insight into pathogenesis and prevention of disease in newborns.

Congenital and perinatal infections with cytomegalovirus (CMV) are responsible for considerable short- and long- term morbidity in infants. CMV is the most common congenital viral infection in the developed world, and is a common cause of neurodevelopmental injury, including mental retardation and sensorineural hearing loss (SNHL). Antiviral therapy has been shown to be valuable in ameliorating the severity of SNHL, but CMV disease control in newborns ultimately depends on successful development of a vaccine.

International adoption: what is fact, what is fiction, and what is the future?

Despite the popularity of international adoption in North America and Western Europe as a means to build a family, the knowledge of health care professionals is often limited regarding the historical context of this phenomenon as well as the motivations and process experienced by adoptive parents. Although international adoption is viewed as an acceptable if not admirable method of forming kinships in accepting countries, opinions in the international community are mixed. Whether international adoptions increase or are drastically curtailed depends on addressing the misgivings that many countries have about placing their children abroad.