Characterization of upper esophageal sphincter pressures relative to vocal acoustics.

Strength of vocal fold adduction has been hypothesized to be a critical factor influencing vocal acoustics but has been difficult to measure directly during phonation. Recent work has suggested that upper esophageal sphincter (UES) pressure, which can be easily assessed, increases with stronger vocal fold adduction, raising the possibility that UES pressure might indirectly reflect vocal fold adduction strength. However, concurrent UES pressure and vocal acoustics have not previously been examined across different vocal tasks.

Time to Resolution of Severe Anemia in Young Children With Iron Deficiency.

Iron deficiency anemia in children remains a pervasive problem. Prolonged iron deficiency anemia (IDA) is linked to adverse neurodevelopmental outcomes, but the duration of severe IDA (hemoglobin <7 g/dL) in children is poorly studied, particularly for racial/ethnic minority groups. We reviewed the electronic medical records of 92 children (1 to 5 y old) with IDA within a major metropolitan health care system.

Patient Preferences for Telemental Health Care in a Federally Qualified Health Center.

: This cross-sectional study evaluated whether preferences for attending mental health visits virtually or in-person vary by demographics and identified factors influencing these preferences among federally qualified health center (FQHC) patients. : FQHC patients ( = 350) completed a satisfaction survey of their mental health care experiences in 2022. Demographic data were obtained from the electronic health record.

Neurocognitive disruption in pediatric kidney transplant candidates: Medical and sociodemographic factors.

We evaluated the effects of kidney failure etiology, dialysis, and area deprivation index on the subdomains of neurocognitive functioning in pediatric kidney transplant candidates. The study included 78 pediatric kidney transplant candidates (47.4% male, 70.

Minnesota Hospitals' Plans for Implementing Statewide Guidance on Allocation of Scarce Critical Care Resources During the COVID-19 Pandemic.

Objectives: To assess hospitals' plans for implementing Minnesota's statewide guidance for allocating scarce critical care resources during the COVID-19 pandemic.

Patients And Methods: Individuals from 23 hospitals across Minnesota were invited to complete a 25-item survey between July 20, 2020, and September 18, 2020 to understand how hospitals in the state intended to operationalize statewide clinical triage instructions for scarce resources (including mechanical ventilation) and written ethics guidance on the allocation of critical care resources in the event crisis standards of care triggered triage.

Results: Of individuals invited from 23 hospitals, 14 hospitals completed the survey (60.

miRNAs in HCC, pathogenesis, and targets.

Liver cancer is the third leading cause of cancer-related mortality worldwide. HCC, the most common type of primary liver cancer, is driven by complex genetic, epigenetic, and environmental factors. MicroRNAs, a class of naturally occurring small noncoding RNAs, play crucial roles in HCC by simultaneously modulating the expression of multiple genes in a fine-tuning manner.

Depression Symptoms Do Not Worsen Over Time in a Cohort of CKD Patients: The BRINK Study.

Background: The prevalence of depression is high in the chronic kidney disease (CKD) (20-40%) and dialysis (30-50%) populations. Less is known about how depressive symptoms change over time in patients with CKD.

Methods: Participants in the Brain in Kidney Disease (BRINK) cohort study completed a depressive symptom questionnaire (PHQ-9) and serum creatinine testing annually.

Cellular senescence in acute human infectious disease: a systematic review.

Introduction: This systematic review explores the relationship between cellular senescence, an age-related inflammatory phenomenon, with acute human infectious disease.

Methods: Embase via OVID, Scopus, Web of Science, Global Index Medicus, Cochrane Library via Wiley, and ClinicalTrials.gov were queried.

A protocol for modifying progesterone to increase postpartum cigarette smoking abstinence and reduce secondhand smoke exposure in infants.

Unlabelled: New interventions are necessary to increase postpartum abstinence from cigarette smoking. Sex hormones, specifically progesterone, have been found to be protective against drug-taking behaviors. Our pilot double-blind, randomized, controlled trial, although underpowered, suggested a trend toward a higher prevalence of smoking abstinence among postpartum participants receiving exogenous progesterone compared to those receiving placebo.

A novel electrocardiogram-based model for prediction of dementia-The Atherosclerosis Risk in Communities (ARIC) study.

Aim: Create an ECG-based model to predict dementia and compare its performance with the existing Cardiovascular Risk Factors, Aging, and Dementia (CAIDE) model.

Methods And Results: Participants without prevalent dementia in the Atherosclerosis Risk in Communities study were studied. Visit 4 (V4) (1996-98, mean age, 62 years) and V5 (2011-13, mean age, 75 years) were used as baselines.

The N-terminus of the transferase A component directs toxin activity and potency.

infection is the leading cause of antibiotic-associated, hospital-acquired diarrhea in the USA; the pathology of which is mediated by toxins. The presence of a toxin known as the Transferase (CDT) in some clinical isolates is linked to severe symptoms including increased incidence of reinfection and higher rates of mortality. Despite its apparent importance to pathology, a mechanistic model of how CDT intoxicates cells remains incomplete.

Novel Model of Childhood Appetitive Traits in Children with Obesity.

Background/objectives: Appetitive traits have a central role in energy intake and development of obesity. Child Eating Behavior Questionnaire (CEBQ) is a validated psychometric tool to measure appetitive traits in children. This study sought to assess the CEBQ factor structure in children with obesity.

Study design features increase replicability in brain-wide association studies.

Brain-wide association studies (BWAS) are a fundamental tool in discovering brain-behaviour associations. Several recent studies have shown that thousands of study participants are required for good replicability of BWAS. Here we performed analyses and meta-analyses of a robust effect size index using 63 longitudinal and cross-sectional MRI studies from the Lifespan Brain Chart Consortium (77,695 total scans) to demonstrate that optimizing study design is critical for increasing standardized effect sizes and replicability in BWAS.

The Ercc1 mouse model of XFE progeroid syndrome undergoes accelerated retinal degeneration.

Age-related macular degeneration (AMD) is a major cause of vision loss in older adults. AMD is caused by degeneration in the macula of the retina. The retina is the highest oxygen consuming tissue in our body and is prone to oxidative damage.

Treatment persistence, adherence and healthcare resource utilisation for iGlarLixi versus basal-bolus insulin or premixed insulin in older adult ethnic minorities with type 2 diabetes: SoliEthnicity study.

Aims: Most type 2 diabetes (T2D) studies have predominantly enrolled White people aged <65 years. This retrospective study evaluated outcomes for iGlarLixi (fixed-ratio combination [FRC] of insulin glargine 100 U/mL and lixisenatide) versus basal-bolus or premixed insulin in African American, Asian and Hispanic adults with T2D aged ≥65 years.

Methods: Medicare claims data were assessed from beneficiaries receiving basal insulin who newly initiated iGlarLixi, basal-bolus insulin, or premixed insulin between 7/1/2019 and 12/30/2021.

Deceased Donor Infectious Diseases Testing and Antimicrobial Use: Surveys of Organ Procurement Organizations and Transplant Professionals.

Background: Donor screening and antimicrobial management processes are inconsistent across organ procurement organizations (OPOs) and transplant centers. As part of a Controversies Conference addressing the evaluation and management of infectious diseases (ID) in deceased donors sponsored by the American Society of Transplantation (AST), two online pre-meeting surveys were developed to inform conference proceedings and assess current practices and opinions on donor screening and antimicrobial management.

Methods: Survey 1 addressed the current state of deceased donor ID testing, culture data communication, antimicrobial utilization, and involvement of transplant ID during donor management and was distributed to all 56 United States OPOs.

Adverse Childhood Experiences and Perinatal Mental Health: A Review of Progress and Future Directions.

Purpose Of Review: This review includes recent literature on adverse childhood experiences (ACEs) and perinatal mental health. We summarize key findings, including meta-analytic reviews and emerging data on broad risks for psychopathology, mechanistic pathways, protective factors, and ACEs screening within clinical care contexts.

Recent Findings: ACEs are associated with small to moderate risks for perinatal depression and anxiety.

Acute kidney failure from ingestion of "wood bleach" beekeeping miticide.

Wood bleach is >95 % oxalic acid formulation used off-label as a miticide for Varroa mites by hobbyist beekeepers. Wood bleach (oxalic acid) ingestions are poorly documented in the medical literature. A 46-year-old man presented to the emergency department nauseated and vomiting after accidentally ingesting "bleach and grain ethanol intended for use in beekeeping.