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M1 and M2 macrophages' clinicopathological significance in cutaneous melanoma.
Melanoma Res
June 2017
aDepartment of Health Sciences, Unit of Pathology bDepartment of Health Sciences, Division of Dermatology, University of Milan cUnit of Pathology, ASST Santi Paolo e Carlo, Milan, Italy.
Skin malignant melanoma (MM) is an aggressive cancer with an increasing incidence with limited therapies in advanced stages. Tumor-associated macrophages (TAMs) are the major immune constituent of the MM microenvironment and contribute toward its prognosis. TAMs' characterization and localization in human cancer is important to understand cancer progression and to identify molecular personalized therapies.
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