1 results match your criteria: "University of Michigan and Surgical Service[Affiliation]"
Granulocyte-macrophage colony-stimulating factor rescues human polymorphonuclear leukocytes from ultraviolet irradiation-accelerated apoptosis.
J Surg Res
January 1999
Departments of Surgery and Biological Chemistry, University of Michigan and Surgical Service, Ann Arbor, Michigan, 48105, USA.
Introduction: Bacterial lipopolysaccharide (LPS) and granulocyte-macrophage colony-stimulating factor (GM-CSF) delay PMN apoptosis during in vitro culture. The present study was undertaken to determine if LPS and GM-CSF can rescue UV-irradiated PMN from undergoing apoptosis and to determine the role of extracellular signal-regulated kinase (ERK) in this process.
Materials And Methods: PMN were preincubated with LPS (20 ng/ml) and GM-CSF (100 units/ml) for 60 min before being UV-irradiated for 15 min.