5 results match your criteria: "University of Michigan Medical School and College of Engineering[Affiliation]"
Modeling Molecular Pathogenesis of Idiopathic Pulmonary Fibrosis-Associated Lung Cancer in Mice.
Mol Cancer Res
March 2024
Center for Molecular Imaging, The University of Michigan Medical School, Ann Arbor, Michigan.
Unlabelled: Idiopathic pulmonary fibrosis (IPF) is characterized by progressive, often fatal loss of lung function due to overactive collagen production and tissue scarring. Patients with IPF have a sevenfold-increased risk of developing lung cancer. The COVID-19 pandemic has increased the number of patients with lung diseases, and infection can worsen prognoses for those with chronic lung diseases and disease-associated cancer.
View Article and Find Full Text PDFIt's time to bring human factors to primary care policy and practice.
Appl Ergon
May 2020
International Collaborative to Improve Primary Care Through Industrial and Systems Engineering (I-PrACTISE), USA; University of Wisconsin School of Medicine and Public Health, USA; University of Wisconsin Department of Industrial and Systems Engineering, USA.
Article Synopsis
- Primary health care is a complicated process that isn't always done well, and many health professionals feel burned out.
- Experts tried to improve this situation but were not very successful because they didn't fully understand how primary health care works.
- A conference in 2012 aimed to explore how human factors can help improve primary care and identified four main research areas to focus on for future improvements: understanding people’s needs, getting patients involved, taking care of communities, and making care work better together.
Characterization, Dynamics, and Mechanism of CXCR4 Antagonists on a Constitutively Active Mutant.
Cell Chem Biol
May 2019
Department of Pharmacology, Yale School of Medicine, New Haven, CT 06510, USA. Electronic address:
The G protein-coupled receptor (GPCR) CXCR4 is a co-receptor for HIV and is involved in cancers and autoimmune diseases. We characterized five purine or quinazoline core polyamine pharmacophores used for targeting CXCR4 dysregulation in diseases. All were neutral antagonists for wild-type CXCR4 and two were biased antagonists with effects on β-arrestin-2 only at high concentrations.
View Article and Find Full Text PDFEndothelial CXCR7 regulates breast cancer metastasis.
Oncogene
March 2016
University of Michigan Center for Molecular Imaging, Department of Radiology, University of Michigan Medical School and College of Engineering, Ann Arbor, MI, USA.
Atypical chemokine receptor CXCR7 (ACKR3) functions as a scavenger receptor for chemokine CXCL12, a molecule that promotes multiple steps in tumor growth and metastasis in breast cancer and multiple other malignancies. Although normal vascular endothelium expresses low levels of CXCR7, marked upregulation of CXCR7 occurs in tumor vasculature in breast cancer and other tumors. To investigate effects of endothelial CXCR7 in breast cancer, we conditionally deleted this receptor from vascular endothelium of adult mice, generating CXCR7(ΔEND/ΔEND) animals.
View Article and Find Full Text PDFImproving RCA performance: the Cornerstone Award and the power of positive reinforcement.
BMJ Qual Saf
November 2011
University of Michigan Medical School and College of Engineering, Ann Arbor, MI, USA.
Background: The Veterans Health Administration has had a comprehensive patient safety program since 1999 that includes conducting root cause analysis (RCA) of adverse medical events. Improving the quality and timeliness of the RCAs at the local level has been a continual challenge.
Methods: We initiated a non-monetary program called the Cornerstone Award into our patient safety reporting system to recognise facilities conducting high-quality and timely RCAs containing deterministic corrective actions that are implemented and evaluated for effectiveness.