Quantifying mineralization using bone mineral density distribution in the mandible.

Background: Micro-computed tomography is an efficient method for quantifying the density and mineralization of mandibular microarchitecture. Conventional radiomorphometrics such as bone and tissue mineral density are useful in determining the average overall mineral content of a scanned specimen; however, relying solely on these metrics has limitations. Using bone mineral density distribution (BMDD), the complex array of mineralization densities within a bone sample can be portrayed.

Deferoxamine enhances the vascular response of bone regeneration in mandibular distraction osteogenesis.

Background: Bone regeneration during distraction osteogenesis is intricately associated with an enhanced vascular response. Augmenting this response may offer considerable clinical advantages such as optimizing the quality of regenerate formation, decreasing lengthy consolidation periods, or increasing regenerate size and distance. Using deferoxamine, an angiogenic transcriptional activator, the authors posit that substantial increases in vascular volume beyond the normal response to mechanical distraction can be quantified with micro-computed tomography after vessel perfusion during mandibular distraction osteogenesis.