3 results match your criteria: "University of Miami School of Medicine and the Sylvester Comprehensive Cancer Center[Affiliation]"
Diminished expression of transcription factors nuclear factor kappaB and CCAAT/enhancer binding protein underlies a novel tumor evasion mechanism affecting macrophages of mammary tumor-bearing mice.
Cancer Res
November 2005
Department of Microbiology and Immunology, University of Miami School of Medicine and the Sylvester Comprehensive Cancer Center, Miami, Florida 33101, USA.
Interactions between malignant tumors and the host immune system shape the course of cancer progression. The molecular basis of such interactions is the subject of immense interest. Proinflammatory cytokines produced by macrophages are critical mediators of immune responses that contribute to the control of the advancement of neoplasia.
View Article and Find Full Text PDFDiminished PKC activity and decreased binding of transcription factors are involved in the impaired production of nitric oxide by macrophages from tumor-bearing mice.
Int J Mol Med
March 2005
Department of Microbiology and Immunology, University of Miami School of Medicine and the Sylvester Comprehensive Cancer Center, Miami, FL 33136, USA.
Article Synopsis
- The study investigates how peritoneal macrophages from tumor-bearing mice have reduced ability to attack tumor cells and produce nitric oxide (NO) when stimulated, which could be improved by IFN-gamma.
- It focuses on the role of signaling molecules and transcription factors in the decreased expression of the iNOS gene, which is responsible for NO production.
- Findings reveal that reduced PKC activity, as well as changes in transcription factor binding, contribute to the lower iNOS levels and, consequently, the impaired immune response in these tumor-associated macrophages.
Altered IL-12 Signaling Pathways Contribute to the Deficient IFN-γ Production by T Splenocytes from Tumor-bearing Mice.
Cancer Genomics Proteomics
September 2004
Department of Microbiology and Immunology, University of Miami School of Medicine and the Sylvester Comprehensive Cancer Center, Miami, FL 33136, U.S.A.
IFN-γ is a crucial cytokine produced by T and NK cells. Previous work from our laboratory has reported that in T cells of BALB/c mice bearing the D1-DMBA-3 mammary tumor, IFN-γ production is down-regulated, due to decreased expression of IL-12 by macrophages of tumor bearers. IL-12 is the main inducer of IFN-γ production in T and NK cells.
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