2 results match your criteria: "University of Miami Miller School of Medicine (UMMSOM)[Affiliation]"
Inhibition of Vasculogenic Mimicry and Angiogenesis by an Anti-EGFR IgG1-Human Endostatin-P125A Fusion Protein Reduces Triple Negative Breast Cancer Metastases.
Cells
October 2021
Sylvester Comprehensive Cancer Center, Department of Medicine, Division of Hematology, University of Miami Miller School of Medicine (UMMSOM), Miami, FL 33136, USA.
Article Synopsis
- Triple negative breast cancer (TNBC) is a tough-to-treat cancer subtype that often leads to high mortality due to its aggressive nature and tendency to spread (metastasize).
- A novel anti-EGFR antibody-endostatin fusion protein, αEGFR-E-P125A, was developed to target EGFR-expressing TNBC tumors, showing strong potential in reducing tumor cell motility and disruption of abnormal blood vessel formation (vasculogenic mimicry) in lab tests.
- In animal studies, αEGFR-E-P125A effectively inhibited tumor growth and metastasis, making it a promising approach for preventing the spread of TNBC due to its dual action against angiogenesis and tumor cell behavior
Integrative analysis of miRNA and mRNA paired expression profiling of primary fibroblast derived from diabetic foot ulcers reveals multiple impaired cellular functions.
Wound Repair Regen
November 2016
Department of Dermatology & Cutaneous Surgery, University of Miami Miller School of Medicine (UMMSOM), Wound Healing and Regenerative Medicine Research Program.
Diabetic foot ulcers (DFUs) are one of the major complications of diabetes. Its molecular pathology remains poorly understood, impeding the development of effective treatments. Although it has been established that multiple cell types, including fibroblasts, keratinocytes, macrophages, and endothelial cells, all contribute to inhibition of healing, less is known regarding contributions of individual cell type.
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