Etiological Aspects of Infectious Endocarditis in a Tertiary Hospital in Northeastern Romania.

: Infective endocarditis (IE) is a severe, life-threatening infection of the endocardial surface. Its incidence has shifted towards older, immunocompromised patients and those with cardiac devices. : This study was conducted at the "Sf.

Efficacy and safety of different hyaluronic acid fillers on cheek volume augmentation: systematic review and network meta-analysis.

Background: Various rejuvenation surgeries, including hyaluronic acid (HA) fillers, aim to address mid-face volume loss. However, literature on the comparative efficacy and safety of different HA fillers for the zygomatic area remains limited.

Methods: This systematic review and network meta-analysis (NMA), adhering to NMA PRISMA 2020 and Cochrane guidelines.

Bell's Palsy and COVID-19 Vaccines: A Systematic Review and Meta-Analysis.

Introduction: Once the COVID-19 pandemic was declared, the world was waiting for the clue that would be able to cut down the progression of the disease. Vaccines play a crucial role in reducing the disease and saving many people worldwide. However, there are several side effects of these vaccines, like pain, fatigue, fever, and neurological defects like Bell's palsy.

Day 5 versus day 3 embryo biopsy for preimplantation genetic testing for monogenic/single gene defects.

Background: Assisted reproductive technology (ART) has allowed couples with a family history of a monogenic genetic disease, or a disease-carrying gene, to reduce the chance of them having a child with the genetic disorder. This is achieved by genetically testing the embryos using an advanced process called preimplantation genetic testing for monogenic or single gene disorders (PGT-M), such as Huntington's disease or cystic fibrosis. This current terminology (PGT-M) has replaced the formerly-known preimplantation genetic diagnosis (PGD).

Significant Differences in IBD Care and Education across Europe: Results of the Pan-European VIPER Survey.

Background: Inflammatory bowel disease (IBD) care and education might differ around Europe. Therefore, we conducted this European Variation In IBD PracticE suRvey (VIPER) to investigate potential differences between countries.

Methods: This trainee-initiated survey, run through SurveyMonkey®, consisted of 47 questions inquiring basic demographics, IBD training, and clinical care.

Long-Term Examination of Degradation and In Vivo Biocompatibility of Some Mg-0.5Ca-xY Alloys in Sprague Dawley Rats.

The medical field has undergone constant development in recent years, and a segment of this development is occupied by biodegradable alloys. The most common alloys in this field are those based on Mg, their main advantage being the ability to degrade gradually, without affecting the patient, and also their ability to be fully absorbed by the human body. One of their most important conditions is the regeneration and replacement of human tissue.

Maggot Debridement Therapy for Chronic Leg and Foot Ulcers: A Review of Randomized Controlled Trials.

Objective: To critically analyze the existing randomized controlled trials (RCTs) on the clinical, economic, and psychological implications of maggot debridement therapy (MDT).

Data Sources: An exhaustive literature search for English-language publications was conducted using MEDLINE, EMBASE, and PubMed.

Study Selection: Keywords used for the search were based on the PICO (Population, Intervention, Comparison, Outcome) framework.

Duplex echography as an adjuvant tool to clinical examination to detect early postoperative free flap vascular compromise.

Background: Clinical examination remains the cornerstone for postoperative monitoring of free flaps but is highly dependent on the surgeon's ability and experience. Duplex echography provides a noninvasive objective evaluation of tissue perfusion. The authors hypothesized that duplex echography may be a more sensitive and specific monitoring method for early detection of postoperative flap compromise compared to clinical examination alone.

Support for e-cigarette policies among smokers in seven European countries: longitudinal findings from the 2016-18 EUREST-PLUS ITC Europe Surveys.

Background: The 2016 European Tobacco Products Directive (TPD) required Member States (MS) to implement new regulations for electronic cigarettes (ECs). We conducted a longitudinal study to assess changes over 2 years in smokers' support for EC policies and identify predictors of support in seven European countries after TPD implementation.

Methods: Prospective cohort surveys were conducted among adult smokers in Germany, Greece, Hungary, Poland, Romania, Spain and England in 2016 (n = 9547; just after TPD) and 2018 (n = 10 287; 2 years after TPD).

Hand, foot and mouth disease--outbreak in Romania?

Hand, foot and mouth disease (HFMD) is a viral illness usually occurring during the summer months in children younger than 5 years of age. In the North-East area of Romania the incidence is usually low, each dermatologist reporting 1-2 cases or even less per year. The diagnosis is usually based on the characteristic clinical aspect: vesicles and papules on the hands and feet and superficial oral ulcers.

Metformin induced lactic acidosis--particularities and course.

Diabetes mellitus is a widespread disease with many serious chronic complications. An improvement in the oral antidiabetic medication in respect to its mechanism of action and toxicology was needed in order to have effective therapies with high compliance and minimum side effects. In this context, metformin is a widely used oral antidiabetic drug, which, through its mechanism of action, has no risk of hypoglycemia.

Hyponatremia at autopsy: cause of death or simply a marker of severity of the underlying disease.

Aim: To analyze the possible interpretations of hyponatremia detected at autopsy in vitreous humor in relation to the cause of death and/or associated pathology (cause of death or a simple marker of the severity of associated diseases).

Material And Methods: Hyponatremia is the most common electrolytic disorder in hospital practice, considered as a risk factor for hospital mortality. We conducted a 3-year forensic casework analysis in view ofestablishing the relationship of hyponatremia with mortality: hyponatremia as a direct cause of death or hyponatremia caused by the severity of the underlying disease which is the cause of death.

Statistical study on the incidence of allergic diseases treated with desloratadine and levocetirizine at "Atopia" Allergology Medical Center, Iaşi, Romania.

Unlabelled: Allergies and allergic manifestations are a major health problem in our country and around the world. Epidemiological data have reported an increased incidence of allergic diseases up to 10-30% over the past decades.

Aim: To evaluate the incidence of the most common allergic diseases treated with desloratadine or levocetirizine, second-generation antihistamines.

Development and validation of a spectrophotometric method for quantitative determination of new preservatives from pharmaceutical forms.

Aim: A spectrophotometric UV-VIS fast, sensitive and simple method was developed for quantitative determination of two new antimicrobial preservatives (oxi-acetyl-mandelic acid and oxi-propionyl mandelic acid) and validated according to validation quides.

Material And Methods: The absorption spectra were recorded at 200-400 nm, and the absorbances were measured at 256 nm for oxi-acetyl mandelic acid and 258 nm for oxipropionyl mandelic acid. Optimum working conditions were established and the method was validated.

Quantitative and qualitative bone assessment of the posterior mandible in patients with diabetes mellitus: a cone beam computed tomography study.

Unlabelled: Evaluation of mandibular bone features is very important for the diagnosis, treatment planning and management of dental procedures such as osseointegrated implants.

Aim: To evaluate the bone quantity and quality of the posterior region of the mandible using the CBCT technique for implant planning in patients with diabetes mellitus.

Methods: Twenty-three patients with diabetes mellitus and 27 control subjects participated in the study.

Age at initiation of sexual life, protection at first intercourse and sources of information regarding sexual and reproductive health.

Objectives: this study is intended to determine: age at initiation of sexual life, protection at first intercourse and sources of information regarding sexual and reproductive health. The trends identified by this study can form the basis of public health programmes.

Material And Methods: between 2011 and 2012, 564 subjects, 18-35 years old, from urban and rural environment, have responded to a questionnaire with 96 items on family-related topics.

Current status in vitamin D and regulatory T cells--immunological implications.

There has been a continuous effort to understand possible non-Ca metabolism roles of vitamin D, including its role in the immune system and, in particular, in T cell-medicated immunity. Vitamin D receptor is found in significant concentrations in the T lymphocyte and macrophage populations, when we refer to immune system, and pretty much in any human tissue and cells. Until the eighties, no one had imagined that vitamin D might play a role in the functioning of the immune system.

The correlation between anterior ischemic optic neuropathy the non-arthritic form, and the treatment involving alpha-interferon.

The anterior ischemic optic neuropathy is an uncommon complication of alpha-Interferon treatment, characterized by the either temporary or permanent diminishing in visual acuity. We are hereby presenting the clinical case of an anterior ischemic optic neuropathy (non-arteritic form) complicating interferon therapy for Chronic Hepatitis C. In such cases we recommend ophthalmological examinations and if severe ophthalmologic complications occur antiviral treatment should be stopped immediately.

Unmasking a young adult migratory deep venous thrombosis--case report.

Venous thromboembolism is a known complication of cancer which impacts on patient mortality and quality of life. The primary site of cancer is an important risk factor, with highest rates observed in patients with brain, pancreas, gastric, kidney, ovary and lung cancers. The extent of metastatic spread further adds to the risk.

Relationship between Kuppfer cells, inflammation, and fibrosis in chronic hepatitis B and C.

Kupffer cells are liver parenchymal components of the immune system able of intervention in pathogenic mechanisms involved in viral hepatitis and tumoral lesions. Our study aimed to evaluate the Kupfferian hyperplasia in chronic hepatitis B and C, and to correlate with the severity of liver lesions, focusing on the modality in which Kupffer cells modulate the necroinflammatory events and fibrosis specific for chronic hepatitis morphologic substrate. We investigated 33 cases with chronic hepatitis B and 38 cases with chronic hepatitis C, diagnosed according to Ishak score (in chronic hepatitis B and C) and METAVIR score (in chronic hepatitis C).

Correlations between the presence of sigmoid interventricular septum and increased relapse risk of stroke in hypertensive patients.

Objectives: Comparison between cerebrovascular accident (CVA) relapse in hypertensive patients with sigmoid interventricular septum (SIS) and CVA relapse in hypertensive patients without SIS.

Materials And Methods: We selected 36 hypertensive patients, all of them complicated with previous CVA; 18 patients had SIS (Group A) and 18 patients didn't have SIS (Group B). The utilized methods were the following: clinical examination, electrocardiogram, transthoracic echocardiogram, biochemical findings and complete blood count, performed every 3 months, during 2 years of observation.

Contributions regarding the leaf histo-anatomy of some Pelargonium species.

Unlabelled: Pelargonium L. genra (Fam. Geraniaceae) includes over 250 species, most of it native to southern Africa.