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Alternative polyadenylation: a twist on mRNA 3' end formation.

ACS Chem Biol

October 2008

Department of Biochemistry and Molecular Biology, University of Medicine and Dentistry of New Jersey-New JerseyMedical School, MSB E671, 185 South Orange Avenue, Newark, New Jersey 07101, USA.

Article Synopsis
  • Regulation of gene expression in mammals is influenced significantly by RNA processing mechanisms, including transcription, splicing, and transport.
  • Alternative RNA processing, particularly alternative splicing and polyadenylation, contributes to the diversity of mRNA transcripts derived from a single gene.
  • Recent studies highlight alternative polyadenylation as a vital aspect of gene regulation, with this review focusing on current knowledge and future directions in the field.
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