2 results match your criteria: "University of Medicine and Dentistry of New Jersey New Brunswick[Affiliation]"
Anti-neurotrophic effects from autoantibodies in adult diabetes having primary open angle glaucoma or dementia.
Front Endocrinol (Lausanne)
May 2013
Medical Service, New Jersey Health Care System, Department of Veterans Affairs Lyons, NJ, USA ; Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey New Brunswick, NJ, USA.
Aim: To test for anti-endothelial and anti-neurotrophic effects from autoantibodies in subsets of diabetes having open-angle glaucoma, dementia, or control subjects.
Methods: Protein-A eluates from plasma of 20 diabetic subjects having glaucoma or suspects and 34 age-matched controls were tested for effects on neurite outgrowth in rat pheochromocytoma PC12 cells or endothelial cell survival. The mechanism of the diabetic glaucoma autoantibodies' neurite-inhibitory effect was investigated in co-incubations with the selective Rho kinase inhibitor Y27632 or the sulfated proteoglycan synthesis inhibitor sodium chlorate.