4 results match your criteria: "University of Massachusetts-Memorial Medical Center and Medical School[Affiliation]"
Cerdulatinib, a novel dual SYK/JAK kinase inhibitor, has broad anti-tumor activity in both ABC and GCB types of diffuse large B cell lymphoma.
Oncotarget
December 2015
Department of Pathology, Division of Genomic and Molecular Pathology, University of Chicago, Chicago, IL, USA.
B-cell receptor (BCR) and JAK/STAT pathways play critical roles in diffuse large B-cell lymphoma (DLBCL). Herein, we investigated the anti-lymphoma activity of cerdulatinib, a novel compound that dually targets SYK and JAK/STAT pathways. On a tissue microarray of 62 primary DLBCL tumors, 58% expressed either phosphorylated SYK or STAT3 or both.
View Article and Find Full Text PDFPrevalence and reversibility of pulmonary dysfunction in refractory systemic lupus: improvement correlates with disease remission following hematopoietic stem cell transplantation.
Chest
May 2005
Division of Hematology-Oncology and Bone Marrow Transplantation, University of Massachusetts Memorial Medical Center and Medical School, Worcester, MA, USA.
Aim: To report the prevalence and reversibility of pulmonary function test (PFT) abnormalities among systemic lupus erythematosus (SLE) patients, refractory to therapy, undergoing hematopoietic stem cell transplantation (HSCT).
Methods: Thirty-four SLE patients received 200 mg/kg cyclophosphamide and 90 mg/kg equine antithymocyte globulin followed by HSCT. PFTs were performed prior to, at 6 months, and yearly following HSCT.
Brachioradial pruritus: cervical spine disease and neurogenic/neuropathic [corrected] pruritus.
J Am Acad Dermatol
April 2003
Division of Dermatology, University of Massachusetts Memorial Medical Center and Medical School, USA.
Background: The main cause of brachioradial pruritus (BRP) is not known but there is evidence to suggest that BRP may arise in the nervous system. Cervical spine disease may be an important contributing factor.
Objective: Our aim was to determine whether spine pathology is associated with BRP.
Outcomes and early revascularization for patients > or = 65 years of age with cardiogenic shock.
Am J Cardiol
April 2001
Cardiovascular Division, University of Massachusetts-Memorial Medical Center and Medical School, Worcester, Massachusetts 01655, USA.
Article Synopsis
- Hospital survival rates for elderly patients (age ≥ 65) with acute myocardial infarction complicated by cardiogenic shock have improved from 1986 to 1997.
- The study observed a significant increase in early revascularization strategies and the use of medications like antiplatelet therapy and beta blockers over this period.
- In-hospital mortality dropped from 80% to 69%, indicating that advancements in treatment options have notably enhanced survival outcomes for this high-risk group.