Stereoselective Conversions of Carbohydrate Anomeric Hydroxyl Group in Basic and Neutral Conditions.

The rapidly growing glycoscience has boosted the research on the synthesis of glycans and their conjugates, which are centered on the stereoselective formation of glycosidic bonds. Compared to the mainstream acid-promoted glycosylation method that undergoes the S1 type mechanism, the basic/neutral conditions give better stereo control via the S2 mechanism. Anomeric hydroxyl group transformation, whether to form glycosidic bonds directly or to install a leaving group for later glycosylation, is key to carbohydrate synthesis, and the strategies in the stereo control of these reactions under basic/neutral conditions are summarized in this review.

20 Years of Interteaching Research and Practice: A Tutorial for its Use in the Classroom.

Boyce and Hineline (2002) published their seminal article describing interteaching more than 2 decades ago. Since then, a robust line of research has emerged demonstrating the efficacy of this instructional approach in college classrooms across a variety of subjects, class sizes, levels of instruction, and in the most recent research, across various teaching and learning modalities. The purpose of this article is to provide a guide and resource for those interested in implementing interteaching in their classroom as well as those interested in conducting interteaching research.

Dispersal promotes stability and persistence of exploited yeast mutualisms.

Multi-species mutualistic interactions are ubiquitous and essential in nature, yet they face several threats, many of which have been exacerbated in the Anthropocene era. Understanding the factors that drive the stability and persistence of mutualism has become increasingly important in light of global change. Although dispersal is widely recognized as a crucial spatially explicit process in maintaining biodiversity and community structure, knowledge about how the dispersal of mutualists contributes to the persistence of mutualistic systems remains limited.

An African perspective to biodiversity conservation in the twenty-first century.

Africa boasts high biodiversity while also being home to some of the largest and fastest-growing human populations. Although the current environmental footprint of Africa is low compared to other continents, the population of Africa is estimated at around 1.5 billion inhabitants, representing nearly 18% of the world's total population.

The magnitude of legal wildlife trade and implications for species survival.

The unsustainable use of wildlife is a primary driver of global biodiversity loss. No comprehensive global dataset exists on what species are in trade, their geographic origins, and trade's ultimate impacts, which limits our ability to sustainably manage trade. The United States is one of the world's largest importers of wildlife, with trade data compiled in the US Law Enforcement Management Information System (LEMIS).

Promoting Maternal Health in the Postpartum Period to Advance Birth Equity.

Black birthing people experience lower rates of postpartum follow-up care. The objective of this study was to examine factors associated with postpartum follow-up care and explore suggestions for improving the quality and experience of care during the postpartum period. A survey was conducted among Black birthing people in the Boston area who had delivered an infant within two years of the study.

Exploring Brazilian Immigrant Mothers' Beliefs and Practices Regarding Their Preschool Children's Oral Health: A Qualitative Study Conducted in the United States.

Parents' beliefs and practices significantly shape young children's oral health (OH), particularly during preschool years when these habits are being established. Immigrant parents often face challenges in promoting OH due to cultural, financial, and logistical barriers. This qualitative study explored OH beliefs, practices, and barriers among Brazilian immigrant mothers in the United States (U.

Multiple environmental tracers combined with a constrained Bayesian isotope mixing model to elucidate nitrate and sulfate contamination in a coastal groundwater system.

Several groundwater quality investigations have been conducted in coastal regions that are commonly exposed to multiple anthropogenic stressors. Nonetheless, such studies remain challenging because they require focused-diagnostic approaches for a comprehensive understanding of groundwater contamination. Therefore, this study integrates a multi-tracer approach to acquire comprehensive information allowing for an improved understanding of the origins of groundwater contamination, the relative contribution of contaminants, and their biogeochemical cycling within a coastal groundwater system.

Correlation of physicochemical properties with antioxidant activity in phenol and thiophenol analogues.

Oxidative stress, associated with excessive production of reactive oxygen and nitrogen species (ROS, RNS), contributes to the development and progression of many ailments, such as aging, cardiovascular diseases, Alzheimer's disease, Parkinson's disease, diabetes, cancer, preeclampsia or multiple sclerosis. While phenols and polyphenols are the most studied antioxidants structurally similar compounds such as anilines or thiophenols are sporadically analyzed despite their radical scavenging potential. This work assesses the impact of structural features of phenols and thiophenols on their antioxidant activity.

The Spirit of Human Rights: Universal Health Coverage in Makueni County, Kenya.

In view of the United Nations' goal to achieve universal health coverage (UHC) by 2030, this paper investigates MakueniCare, the highly successful UHC program in Makueni County, Kenya, to reveal the spirit of human rights underlying it. Drawing on international, Kenyan, and Makueni County law and policy, as well as 30 interviews with government and civil society leaders in health care policy and programming at the national and county levels, we examine the human rights law and principles that underlie the adoption and implementation of MakueniCare. We first set out key human rights principles grounded in the International Covenant on Economic, Social and Cultural Rights and the 2010 Kenyan Constitution, and then describe the research design and methodology of the project.

Solution-Focused Brief Therapy for Improving Couple Dyadic Relationships in Iran: A Systematic Review.

Despite the popularity of Solution-Focused Brief Therapy (SFBT) in Iran, the existing literature synthesis has limitations due to the reliance on studies published primarily in Farsi. This systematic review addresses these gaps by synthesizing and evaluating the effectiveness of SFBT on the marital outcomes of couples in Iran, incorporating both Farsi and English sources. The search for this review yielded 1523 records, from which 26 randomized controlled trials were included.

- a large-scale dataset of 3D medical shapes for computer vision.

Objectives: The shape is commonly used to describe the objects. State-of-the-art algorithms in medical imaging are predominantly diverging from computer vision, where voxel grids, meshes, point clouds, and implicit surface models are used. This is seen from the growing popularity of ShapeNet (51,300 models) and Princeton ModelNet (127,915 models).

Cardiovascular hemodynamic response to peak exercise in individuals with multiple sclerosis.

Multiple sclerosis (MS) is a chronic neurological condition resulting in decreased aerobic capacity (peak VO). The hemodynamic responses to peak exercise in MS are unknown. Further, it is unknown if the hemodynamic responses are due to disease or fitness.

Estimating the prevalence of diabetic retinopathy in electronic health records with massive missing labels.

Objective: The paper aims to address the problem of massive unlabeled patients in electronic health records (EHR) who potentially have undiagnosed diabetic retinopathy (DR). It is desired to estimate the actual DR prevalence in EHR with 96 % missing labels.

Materials And Methods: The Cerner Health Facts data are used in the study, with 3749 labeled DR patients and 97,876 unlabeled diabetic patients.

Chlorophyllase from Reveals an Emerging Model for Controlling Chlorophyll Hydrolysis.

Chlorophyll (Chl) is one of Nature's most complex pigments to biosynthesize and derivatize. This pigment is vital for survival and also paradoxically toxic if overproduced or released from a protective protein scaffold. Therefore, along with the mass production of Chl, organisms also invest in mechanisms to control its degradation and recycling.

Exploring Black Birthing Experiences: A Systematic Review and Social-Ecological Analysis of Disparities in the United States.

Background: Black birthing people in the United States face disproportionately high risks and adverse experiences during childbirth compared to their White counterparts. These challenges are shaped by a complex interplay of factors across individual, interpersonal, organizational, community, and policy levels.

Objective: This systematic review explores the lived experiences of Black birthing people in the United States, using the Social Ecological Model to identify and analyze factors contributing to disparities in Black birthing health experiences.

A Compensated Clock: Temperature and Nutritional Compensation Mechanisms Across Circadian Systems.

Circadian rhythms are ∼24-h biological oscillations that enable organisms to anticipate daily environmental cycles, so that they may designate appropriate day/night functions that align with these changes. The molecular clock in animals and fungi consists of a transcription-translation feedback loop, the plant clock is comprised of multiple interlocking feedback-loops, and the cyanobacterial clock is driven by a phosphorylation cycle involving three main proteins. Despite the divergent core clock mechanisms across these systems, all circadian clocks are able to buffer period length against changes in the ambient growth environment, such as temperature and nutrients.

Association of individual and neighborhood socioeconomic status with outcomes of a smoking cessation intervention provided in the lung cancer screening setting.

Background: Lung cancer screening (LCS) offers a teachable moment for smoking cessation. This study assesses whether individual- or neighborhood-level SES is associated with tobacco abstinence and completion of a smoking cessation intervention in the LCS context.

Methods: Secondary analysis of a clinical trial (NCT03611881) that tested the effectiveness of smoking cessation treatment for smokers scheduled for LCS (N = 615) in eastern Massachusetts, USA from 2019 to 2024.

Longitudinal stability and predictive value of socio/emotional/behavioral screening in an Outpatient Pediatric Network.

Background: In 2022, the American Academy of Pediatrics recommended annual social/emotional/behavioral (SEB) screening at preventive pediatric visits. Numerous SEB screeners have considerable empirical support for children of all ages. However, few studies inform the longitudinal use of SEB screeners in pediatrics.