7 results match your criteria: "University of Massachusetts Medical Schoolgrid.168645.8[Affiliation]"
mSystems
October 2022
Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Longitudinal microbiome data sets are being generated with increasing regularity, and there is broad recognition that these studies are critical for unlocking the mechanisms through which the microbiome impacts human health and disease. However, there is a dearth of computational tools for analyzing microbiome time-series data. To address this gap, we developed an open-source software package, Microbiome Differentiable Interpretable Temporal Rule Engine (MDITRE), which implements a new highly efficient method leveraging deep-learning technologies to derive human-interpretable rules that predict host status from longitudinal microbiome data.
View Article and Find Full Text PDFJ Bacteriol
June 2022
Department of Microbiology, University of Massachusetts, Amherst, Massachusetts, USA.
Cell wall peptidoglycan is a heteropolymeric mesh that protects the bacterium from internal turgor and external insults. In many rod-shaped bacteria, peptidoglycan synthesis for normal growth is achieved by two distinct pathways: the Rod complex, comprised of MreB, RodA, and a cognate class B penicillin-binding protein (PBP), and the class A PBPs (aPBPs). In contrast to laterally growing bacteria, pole-growing mycobacteria do not encode an MreB homolog and do not require SEDS protein RodA for growth.
View Article and Find Full Text PDFmSystems
June 2022
Department of Immunology & Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.
J Virol
March 2022
Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical Schoolgrid.168645.8, Worcester, Massachusetts, USA.
Many oseltamivir resistance mutations exhibit fitness defects in the absence of drug pressure that hinders their propagation in hosts. Secondary permissive mutations can rescue fitness defects and facilitate the segregation of resistance mutations in viral populations. Previous studies have identified a panel of permissive or compensatory mutations in neuraminidase (NA) that restore the growth defect of the predominant oseltamivir resistance mutation (H275Y) in H1N1 influenza A virus.
View Article and Find Full Text PDFmBio
December 2021
Department of Microbiology and Physiological Systems, University of Massachusetts Medical Schoolgrid.168645.8, Worcester, Massachusetts, USA.
spp. are highly adapted pathogens that cause bacillary dysentery in human and nonhuman primates. An unusual feature of pathogenesis is that this organism invades the colonic epithelia from the basolateral pole.
View Article and Find Full Text PDFmSystems
October 2021
Department of Computer Science and Engineering, Texas A&M University, College Station, Texas, USA.
mBio
October 2021
Instituto Rene Rachou, FIOCRUZ-MG, Belo Horizonte, Minas Gerais, Brazil.
Toxoplasmosis affects one-third of the human population worldwide. Humans are accidental hosts and are infected after consumption of undercooked meat and water contaminated with Toxoplasma gondii cysts and oocysts, respectively. Neutrophils have been shown to participate in the control of T.
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