619 results match your criteria: "University of Massachusetts Medical School - Baystate[Affiliation]"

Background: Chronic pain following traumatic stress exposure (TSE) is common. Increasing evidence suggests inflammatory/immune mechanisms are induced by TSE, play a key role in the recovery process versus development of post-TSE chronic pain, and are sex specific. In this study, we tested the hypothesis that the inflammatory marker C-reactive protein (CRP) is associated with chronic pain after TSE in a sex-specific manner.

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The tobacco epidemic has claimed countless lives, caused significant morbidity, and cost billions of dollars in direct costs and lost productivity. Despite its acute vascular effects, nicotine alone has not been definitively linked to cardiovascular events. Rather, additives found in cigarettes and other tobacco products likely play a bigger role in tobacco's link to cardiovascular events.

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  • In recent rural U.S. studies, individuals who use drugs (PWUD) are increasingly combining opioids with stimulants like methamphetamine and cocaine.
  • Among 2,705 PWUD surveyed, 74% reported using both opioids and stimulants, with 76% having undergone hepatitis C virus (HCV) testing.
  • Those who used opioids alone had lower rates of HCV testing, and those using both opioids and stimulants were less likely to have received anti-HCV medication compared to those using other drugs.
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Social Buffering of PTSD: Longitudinal Effects and Neural Mediators.

Biol Psychiatry Cogn Neurosci Neuroimaging

November 2024

Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, 30329, USA. Electronic address:

Article Synopsis
  • This study investigates how early social support after trauma affects PTSD symptoms over time and explores specific brain regions involved in this process, such as the amygdala and ventromedial prefrontal cortex.
  • Using data from 315 participants in the AURORA study, researchers measured PTSD symptoms and perceived emotional support at multiple time points, while also conducting neuroimaging two weeks post-trauma.
  • The results show that early emotional support is linked to changes in white matter connectivity between key brain areas, but it also highlighted unexpected increased threat reactivity in the default mode network, suggesting complex neural pathways in response to social threats.
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  • - The study explored the use of wrist-wearable devices to track heart rate variability (HRV) as potential biomarkers for recovery from adverse neuropsychiatric effects following traumatic events, specifically in a socioeconomically disadvantaged group.
  • - Researchers monitored participants within 72 hours of a traumatic event and over a course of 6 months, validating HRV characteristics linked to various posttraumatic symptoms, such as pain, re-experiencing, and anxiety.
  • - The findings indicate that changes in HRV could effectively predict improvements or worsening in symptoms, suggesting that these wearable technologies could serve as useful screening tools for identifying posttraumatic stress in high-risk populations.
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  • - The study investigates sex/gender differences in PTSD by examining 16 risk factors and their impact on PTSD severity in a group of 2,924 acutely traumatized individuals.
  • - It finds that six risk factors are more prevalent in women, while none are more pronounced in men, highlighting unique pathways contributing to PTSD severity based on sex assigned at birth.
  • - The results indicate different risk mechanisms for men and women, suggesting that understanding these differences can help develop targeted mental health interventions and inform future research on other mental disorders.
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Three radiologists representing unique career stages and paths have reflected on tips for achieving personal and career satisfaction that are relevant to their respective stage. Using published resources to lend support to these tips, this review article concludes by offering tangible tools that academic radiology departments can utilize to help customize faculty development to their staff at the various career stages.

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Practice-Based Models of Pediatric Mental Health Care.

Pediatr Clin North Am

December 2024

Department of Psychiatry, University of Massachusetts Medical School - Baystate, 759 Chestnut Street, WG703, Springfield, MA 01199, USA.

Pediatric primary care is widely available in the United States and can help address the growing public health crisis in child and adolescent mental health by providing integrated behavioral health services. This article provides an overview of 3 common models of behavioral health integration in pediatric primary care settings: 1) the Child Psychiatry Access Program model, 2) the Primary Care Behavioral Health model, and 3) the Collaborative Care Model. Pediatric primary care practices may evaluate the different features of each model before adopting an approach for integration and consider tailoring it to their practice environments.

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Recommended guidelines for screening for underlying malignancy in extramammary Paget's disease based on anatomic subtype.

J Am Acad Dermatol

October 2024

Department of Dermatology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois. Electronic address:

Article Synopsis
  • Extramammary Paget's disease (EMPD) can be linked to underlying internal adenocarcinomas, with varying associations based on the EMPD subtype.
  • A systematic literature review identified that perianal EMPD has a higher rate (25%) of associated adenocarcinomas compared to penoscrotal and vulvar types (6% each).
  • The proposed screening algorithms suggest specific tests based on EMPD subtype, emphasizing thorough screening for high-risk perianal cases and more cost-effective approaches for lower-risk penoscrotal and vulvar cases.
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  • Trauma can increase the risk of unhealthy alcohol use, and this study investigates how brain reward systems change after trauma exposure in humans.
  • The research involved 286 participants who were assessed for changes in alcohol use and brain activity through fMRI shortly after experiencing trauma.
  • Findings suggest that heightened brain activity in specific regions (like the VTA) and altered connections between brain areas may lead to increased alcohol consumption following traumatic events, indicating potential targets for early intervention.
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Purpose Of Review: Recent advancements in molecular biology, biotechnology, chemistry/radiochemistry, artificial intelligence, and imaging techniques have significantly propelled the field of cardiovascular molecular imaging. This review aims to provide a comprehensive overview of the current state of cardiovascular positron emission tomography (PET) imaging and cardiac computed tomography (CT), exploring their roles in elucidating molecular and cellular processes, enabling early disease detection, and guiding novel therapeutic interventions for cardiovascular conditions.

Recent Findings: Cardiovascular PET imaging strives to uncover molecular and cellular events preceding visible anatomical manifestations or physiological changes.

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  • A group of heart surgeons and doctors met to talk about how to improve a special type of heart surgery called minimally invasive cardiac surgery (MICS).
  • They want to make sure the surgery uses smaller cuts to make recovery easier for patients while still achieving good results.
  • They believe that to get the best results from MICS, there should be three key parts: smaller surgical cuts, proper care of the heart during surgery, and a program called Enhanced Recovery After Surgery (ERAS) that helps patients heal better afterward.
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Inflammatory myofibroblastic tumors are rare tumors that have been described in virtually all organs. Even though they are extremely rare in the esophagus, several cases have been described in the literature. Surgical resection has been the therapeutic modality used in most of those cases.

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Importance: Research on resilience after trauma has often focused on individual-level factors (eg, ability to cope with adversity) and overlooked influential neighborhood-level factors that may help mitigate the development of posttraumatic stress disorder (PTSD).

Objective: To investigate whether an interaction between residential greenspace and self-reported individual resources was associated with a resilient PTSD trajectory (ie, low/no symptoms) and to test if the association between greenspace and PTSD trajectory was mediated by neural reactivity to reward.

Design, Setting, And Participants: As part of a longitudinal cohort study, trauma survivors were recruited from emergency departments across the US.

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The neurocardiac circuit is integral to physiological regulation of threat and trauma-related responses. However, few direct investigations of brain-behavior associations with replicable physiological markers of PTSD have been conducted. The current study probed the neurocardiac circuit by examining associations among its core regions in the brain (e.

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Burnout is a widespread issue among physicians, including radiologists and radiology trainees. Long hours, isolation, and substantial stress levels contribute to healthcare workers experiencing a substantially higher rate of burnout compared with other professionals. Resident physicians, continuously exposed to stressors such as new clinical situations and performance feedback, are particularly susceptible.

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Background: Knowledge of sex differences in risk factors for posttraumatic stress disorder (PTSD) can contribute to the development of refined preventive interventions. Therefore, the aim of this study was to examine if women and men differ in their vulnerability to risk factors for PTSD.

Methods: As part of the longitudinal AURORA study, 2924 patients seeking emergency department (ED) treatment in the acute aftermath of trauma provided self-report assessments of pre- peri- and post-traumatic risk factors, as well as 3-month PTSD severity.

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  • Research on tumor-bearing mice suggests that cooler temperatures lead to increased tumor growth and suppressed immune response; however, how this relates to human breast cancer survival is uncertain.
  • An analysis of over 270,000 breast cancer patients from SEER data revealed that those living in warmer climates (average temperatures above 56.7°F) had a 7% better overall survival and disease-specific survival compared to those in cooler climates.
  • The study indicates that higher environmental temperatures may improve survival outcomes for breast cancer patients, highlighting the need for further research to explore the reasons behind this pattern and potential treatment implications.
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There are significant challenges to identifying which individuals require intervention following exposure to trauma, and a need for strategies to identify and provide individuals at risk for developing PTSD with timely interventions. The present study seeks to identify a minimal set of trauma-related symptoms, assessed during the weeks following traumatic exposure, that can accurately predict PTSD. Participants were 2185 adults (Mean age=36.

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Background: Post-traumatic stress disorder (PTSD) and substance use (tobacco, alcohol, and cannabis) are highly comorbid. Many factors affect this relationship, including sociodemographic and psychosocial characteristics, other prior traumas, and physical health. However, few prior studies have investigated this prospectively, examining new substance use and the extent to which a wide range of factors may modify the relationship to PTSD.

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Background: Females are more likely to develop posttraumatic stress disorder (PTSD) than males. Impaired inhibition has been identified as a mechanism for PTSD development, but studies on potential sex differences in this neurobiological mechanism and how it relates to PTSD severity and progression are relatively rare. Here, we examined sex differences in neural activation during response inhibition and PTSD following recent trauma.

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This study examines the association between brain dynamic functional network connectivity (dFNC) and current/future posttraumatic stress (PTS) symptom severity, and the impact of sex on this relationship. By analyzing 275 participants' dFNC data obtained ~2 weeks after trauma exposure, we noted that brain dynamics of an inter-network brain state link negatively with current (r=-0.179, = 0.

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