The Global Intellectual Disability Nursing Research Collaboratory: Forming an international transformational nursing network.

Aim: This paper explains how we created the Global Intellectual Disability Nurse Research Collaboratory (GIDNRC), a transformative network. The GIDNRC aims to make improvements in the understanding, research, policy, clinical care, and support provided to people with an intellectual disability.

Background: In 2022, the World Health Organization (WHO) called upon healthcare leaders internationally to take actions to promote more equal healthcare for disabled persons.

A fluorescence polarization assay for high-throughput screening of inhibitors against HIV-1 Nef-mediated MHC-I downregulation.

The multifunctional, HIV-1 accessory protein Nef enables infected cells to evade host immunity and thus plays a key role in viral pathogenesis. One prominent function of Nef is the downregulation of major histocompatibility complex class I (MHC-I), which disrupts antigen presentation and thereby allows the infected cells to evade immune surveillance by the cytotoxic T cells. Therapeutic inhibition of this Nef function is a promising direction of antiretroviral drug discovery as it may revitalize cytotoxic T cells to identify, and potentially clear, hidden HIV-1 infections.

A fluorescence polarization assay for high-throughput screening of inhibitors against HIV-1 Nef-mediated CD4 downregulation.

Therapeutic inhibition of the viral protein Nef is an intriguing direction of antiretroviral drug discovery-it may revitalize immune mechanisms to target, and potentially clear, HIV-1-infected cells. Of the many cellular functions of Nef, the most conserved is the downregulation of surface CD4, which takes place through Nef hijacking the clathrin adaptor protein complex 2 (AP2)-dependent endocytosis. Our recent crystal structure has unraveled the molecular details of the CD4-Nef-AP2 interaction.

mSphere of Influence: The power of observational research.

Katrina Velle is a cell biologist who uses microscopy to study amoebae. In this mSphere of Influence article, she reflects on how a classic paper on by Tilney and Portnoy made an impact on her by highlighting how much we can learn from simply looking at cells.

Establishing Best Practices in Telehealth Care for Adults with Developmental Disabilities in the United States: An e-Delphi Study.

Telehealth care is now a key element of mainstream health care since the COVID-19 pandemic, with all types of health care providers joining the digital revolution. As a population experiencing health care disparities, adults with developmental disabilities and their supporters have described variable experiences with telehealth care that contribute to overall care quality and health outcomes. This e-Delphi study established consensus on best practices in telehealth care for adults with developmental disabilities in the United States.

Juvenile social play predicts adult reproductive success in male bottlenose dolphins.

For over a century, the evolution of animal play has sparked scientific curiosity. The prevalence of social play in juvenile mammals suggests that play is a beneficial behavior, potentially contributing to individual fitness. Yet evidence from wild animals supporting the long-hypothesized link between juvenile social play, adult behavior, and fitness remains limited.

In pop pursuit: social bond strength predicts vocal synchrony during cooperative mate guarding in bottlenose dolphins.

Vocal communication is an emblematic feature of group-living animals, used to share information and strengthen social bonds. Vocalizations are also used to coordinate group-level behaviours in many taxa, but little is known of the factors that may influence vocal behaviour during cooperative acts. Allied male Indo-Pacific bottlenose dolphins () use the 'pop' vocalization as a coercive signal when working together to herd single oestrous females.

American Association of Heart failure nurses' knowledge, barriers and facilitators in conducting research.

Background: To provide high-quality patient care, heart failure (HF) nurses must comprehend/use best evidence; however, HF nurses' ability to do so are unknown.

Objectives: To describe HF nurses' research interest/involvement, confidence, facilitators/motivators, and barriers to lead/collaborate in research studies.

Methods: A descriptive design with convenience sampling and online data collection (Qualtrics) were used with American Association of HF Nurses members.

A human erythrocytes hologram dataset for learning-based model training.

This manuscript presents a paired dataset with experimental holograms and their corresponding reconstructed phase maps of human red blood cells (RBCs). The holographic images were recorded using an off-axis telecentric Digital Holographic Microscope (DHM). The imaging system consists of a 40 × /0.

Federated Fuzzy Clustering for Decentralized Incomplete Longitudinal Behavioral Data.

The use of medical data for machine learning, including unsupervised methods such as clustering, is often restricted by privacy regulations such as the Health Insurance Portability and Accountability Act (HIPAA). Medical data is sensitive and highly regulated and anonymization is often insufficient to protect a patient's identity. Traditional clustering algorithms are also unsuitable for longitudinal behavioral health trials, which often have missing data and observe individual behaviors over varying time periods.

"It's My Secret": Shame as a Barrier to Care in Individuals With Opioid Use Disorder.

Background: Substance use disorder (SUD) is a chronic illness impacting more than 59 million Americans last year. Opioid use disorder (OUD) is a subset of SUD. The literature supports that healthcare providers frequently stigmatize patients with OUD.

Clinical Faculty Orientation Practices in the United States: A Descriptive Study.

Background: Due to the nursing faculty shortage, expert clinical nurses are working as novice clinical instructors (CIs). Orientation is needed to prepare these nurses to teach; however, lack of evidence-based guidelines for orientation programs can lead to variability among institutions.

Purpose: The purpose of this study was to describe clinical nursing faculty orientation practices in the United States.

Exploring Electrospun Scaffold Innovations in Cardiovascular Therapy: A Review of Electrospinning in Cardiovascular Disease.

Cardiovascular disease (CVD) remains the leading cause of mortality worldwide. In particular, patients who suffer from ischemic heart disease (IHD) that is not amenable to surgical or percutaneous revascularization techniques have limited treatment options. Furthermore, after revascularization is successfully implemented, there are a number of pathophysiological changes to the myocardium, including but not limited to ischemia-reperfusion injury, necrosis, altered inflammation, tissue remodeling, and dyskinetic wall motion.

Influence of build orientation and support structure on additive manufacturing of human knee replacements: a computational study.

Developing patient-specific implants has an increasing interest in the application of emerging additive manufacturing (AM) technologies. On the other hand, despite advances in total knee replacement (TKR), studies suggest that up to 20% of patients with elective TKR are dissatisfied with the outcome. By creating 3D objects from digital models, AM enables the production of patient-specific implants with complex geometries, such as those required for knee replacements.

Predictors and barriers to engagement in caring for children with a mental health diagnosis: A qualitative study of caregivers perception of power.

Background: Evidence-based treatments used in managing behaviors of children require caregiver engagement. However, there is a gap in understanding a caregiver's level of comprehension of how they can advocate for their children's mental health needs and how to help their children in the home once outpatient treatment is initiated.

Methods: This was a qualitative study using interviews with semi-structured research questions.

Improving deep PROPELLER MRI via synthetic blade augmentation and enhanced generalization.

In PROPELLER MRI, obtaining sufficient high-quality blade data remains a challenge, so the efficiency and generalization of deep learning-based reconstruction models are deteriorated. Due to narrow rotated and translated blades acquired in PROPELLER, the technique of data augmentation that is used for deep learning-based Cartesian MRI reconstruction cannot be directly applied. To address the issue, this paper introduces a novel approach for the generation of synthetic PROPELLER blades, and it is subsequently employed in data augmentation for undersampled blades reconstruction.

Aircraft observations in a tropical supercluster over the equatorial Indian Ocean during MISO-BOB field campaign.

The Monsoon Intra-Seasonal Oscillations in the Bay of Bengal (MISO-BOB) field campaign was conducted in the Indian Ocean during the 2018 and 2019 summer monsoon seasons. WC-130J aircraft of the 53rd Weather Reconnaissance Squadron of the US Air Force participated in the campaign in June 2018. The dropsonde observations across a tropical supercluster showed zonal wind variations in association with the structure of the convectively coupled Kelvin wave (CCKW).

Source motion via a time-frequency representation at a single sensor.

The Reflections series takes a look back on historical articles from The Journal of the Acoustical Society of America that have had a significant impact on the science and practice of acoustics.

Investigation of electro-vascular phase-amplitude coupling during an auditory task.

Multimodal neuroimaging using electroencephalography (EEG) and functional near-infrared spectroscopy (fNIRS) provides complementary views of cortical processes, including those related to auditory processing. However, current multimodal approaches often overlook potential insights that can be gained from nonlinear interactions between electrical and hemodynamic signals. Here, we explore electro-vascular phase-amplitude coupling (PAC) between low-frequency hemodynamic and high-frequency electrical oscillations during an auditory task.

Voluntary Attrition Among Traditional Baccalaureate Nursing Students: An Integrative Review.

Aim: The purpose of this review is to synthesize what is known about voluntary attrition from baccalaureate nursing education.

Background: Understanding the reasons behind elective, voluntary attrition from nursing programs can help maximize resources and graduate more nurses into the workforce.

Method: An integrative review of the literature was conducted using the search strategy outlined by Whittemore and Knafl.

Follow Your Passion and Discover the Beauty of Being a Nurse Scientist.

Following one's passion can lead nursing educators and scientists to develop nursing knowledge. Influenced by her and her family's experiences with healthcare, Dr. Shannon Avery-Desmarais, a nurse practitioner, nurse educator, and scientist, has developed a theoretical framework with her colleagues to promote minority PhD and DNP student success in nursing education.