1 results match your criteria: "University of Massachusetts Chan Medical Chan Medical School[Affiliation]"
High-fat diet during early life reshapes the gut microbiome and is associated with the disrupted mammary microenvironment in later life in mice.
Nutr Res
July 2024
School of Public Health and Health Sciences, University of Massachusetts, Amherst, MA, USA; UMass Cancer Center, University of Massachusetts Chan Medical Chan Medical School, Worcester, MA, USA. Electronic address:
Article Synopsis
- Gut microbiota significantly affects gut health, but its role in diseases like breast cancer is less understood, especially how early-life gut dysbiosis might contribute to tumor development later on.
- In a study with female mice, those fed a high-fat diet during a critical growth period showed notable changes in their gut microbiome and subsequent disruption in mammary tissue markers, indicating potential links to breast cancer risk.
- The findings suggest that a high-fat diet during early life alters gut microbiome diversity and is associated with metabolic and inflammatory changes in the mammary environment, potentially influencing breast cancer development.