Group based trajectory modeling identifies distinct patterns of sympathetic hyperactivity following traumatic brain injury.

Background: Paroxysmal Sympathetic Hyperactivity (PSH) occurs with high prevalence among critically ill Traumatic Brain Injury (TBI) patients and is associated with worse outcomes. The PSH-Assessment Measure (PSH-AM) consists of a Clinical Features Scale (CFS) and a Diagnosis Likelihood Tool (DLT), intended to quantify the severity of sympathetically-mediated symptoms and likelihood that they are due to PSH, respectively, on a daily basis. Here, we aim to identify and explore the value of dynamic trends in the evolution of sympathetic hyperactivity following acute TBI using elements of the PSH-AM.

Social entrepreneurship and public health nursing knowledge: Opportunities for innovating nursing education in population health.

Unlabelled: Public health nursing (PHN) competencies are fundamental for addressing population health inequities. Few pathways exist for employing these competencies in the United States (US). Social entrepreneurship in nursing education might provide opportunities for innovating engagement in population health.

Transcriptomic analyses of bacterial growth on fungal necromass reveal different microbial community niches during degradation.

Bacteria are major drivers of organic matter decomposition and play crucial roles in global nutrient cycling. Although the degradation of dead fungal biomass (necromass) is increasingly recognized as an important contributor to soil carbon (C) and nitrogen (N) cycling, the genes and metabolic pathways involved in necromass degradation are less characterized. In particular, how bacteria degrade necromass containing different quantities of melanin, which largely control rates of necromass decomposition , is largely unknown.

Stress increases sperm respiration and motility in mice and men.

Semen quality and fertility has declined over the last 50 years, corresponding to ever-increasing environmental stressors. However, the cellular mechanisms involved and their impact on sperm functions remain unknown. In a repeated sampling human cohort study, we identify a significant effect of prior perceived stress to increase sperm motility 2-3 months following stress, timing that expands upon our previous studies revealing significant stress-associated changes in sperm RNA important for fertility.

Unanticipated evolution of cardio-respiratory interactions with cognitive load during a Go-NoGo shooting task in virtual reality.

The cardiovascular system interacts continuously with the respiratory system to maintain the vital balance of oxygen and carbon dioxide in our body. The interplay between the sympathetic and parasympathetic branches of the autonomic nervous system regulates the aforesaid involuntary functions. This study analyzes the dynamics of the cardio-respiratory (CR) interactions using RR Intervals (RRI), Systolic Blood Pressure (SBP), and Respiration signals after first-order differencing to make them stationary.

Which social determinants of health have the highest impact in community oncology to advance patient care equity and improve health outcomes? A scoping review.

Introduction: To better understand the SDOH-health equity landscape within a community oncology setting to answer the research question, "Which SDOH can have the highest impact in community oncology to advance patient care equity and improve health outcomes?"

Methods: Arksey and O'Malley's scoping review framework was used to identify evidence related to SDOH and health equity in community oncology. The study was guided by the "10-Step Framework for Continuous Patient Engagement" and a Community Advisory Board to assure relevance to patients and community providers. Literature was retrieved from literary databases and oncology organizations' websites.

Comparative Population Genomics of Arctic Sled Dogs Reveals a Deep and Complex History.

Recent evidence demonstrates genomic and morphological continuity in the Arctic ancestral lineage of dogs. Here, we use the Siberian Husky to investigate the genomic legacy of the northeast Eurasian Arctic lineage and model the deep population history using genome-wide single nucleotide polymorphisms. Utilizing ancient dog-calibrated molecular clocks, we found that at least two distinct lineages of Arctic dogs existed in ancient Eurasia at the end of the Pleistocene.

Mitigating the effect of COVID-19 in a postemergency phase: The role of sense of community and individual resilience.

To identify and confirm patterns of relationships connecting sense of community (SOC) and individual resilience with psychological well-being, via the mediation of coronavirus disease 2019 (COVID-19) impacts on life domains. An online survey was conducted with a sample of adults (n = 650) 1 year after the COVID-19 outbreak in Italy and the United States (April-December 2021). Utilizing a Structural Equation Model, we tested a mediation model (n = 563) to identify the associations between SOC and individual resilience and the perceived impacts of the emergency situation and psychological well-being.

Determining Individualized Foot Progression Angle for Reduction of Knee Medial Compartment Loading during Stepping.

Purpose: Modifying foot progression angle (FPA), the angle between the line from the heel to the second metatarsal head and the line of progression, can reduce peak knee adduction moment (pKAM). However, determining the optimal FPA that minimizes pKAM without inducing unnatural walking patterns can be challenging. This study investigated the FPA-pKAM relationship using a robotic stepping trainer to assess the feasibility of determining the optimal FPA based on this relationship.

Up-regulation of IL-1β and sPLA2-III in the medial prefrontal cortex contributes to orofacial and somatic hyperalgesia induced by malocclusion via glial-neuron crosstalk.

The medial prefrontal cortex (mPFC) has been identified as a key brain region involved in the modulation of chronic pain. Our recent study demonstrated that unilateral anterior crossbite (UAC) developed the comorbidity model of temporomandibular disorders (TMD) and fibromyalgia syndrome (FMS), which was characterized by both orofacial and somatic hyperalgesia. In the present study, UAC rats exhibited significant changes in gene expression in the mPFC.

The Health Status of Undocumented Immigrants from Asian Countries in the United States: A Scoping Review and Recommendations for Future Directions.

Immigrants from Asian countries are the fastest-growing undocumented population in the United States (U.S.), yet not much is known about their health.

Genetic labeling of the nucleus of tractus solitarius neurons associated with electrical stimulation of the cervical or auricular vagus nerve in mice.

Introduction: Vagus nerve stimulation (VNS) is clinically useful for treating epilepsy, depression, and chronic pain. Currently, cervical VNS (cVNS) treatment is well-established, while auricular VNS (aVNS) is under development. Vagal stimulation regulates functions in diverse brain regions; therefore, it is critical to better understand how electrically-evoked vagal inputs following cVNS and aVNS engage with different brain regions.

UV-activated calcium peroxide system enables simultaneous organophosphorus degradation, phosphate recovery, and carbon fixation.

Advanced oxidation processes are a desirable technology for treatment of contaminants of emerging concern. Nevertheless, conventional advanced oxidation of organophosphorus compounds releases inorganic phosphate, posing downstream concerns related to eutrophication. For this reason, we evaluated the ultraviolet light-activated calcium peroxide (UV/CaO) system for effective treatment of organophosphorus compounds and concurrent capture of the mineralization products, phosphate.

Exploring Biliverdin's Molecular Interactions with Cu- and Fe-Based MOFs: A Unified In Vitro Study with Photoacoustic Analysis.

Metal-organic frameworks (MOFs) have shown promise in enhancing the stability of biomolecules. Herein, biliverdin (BVD), a photoacoustic (PA) and fluorescent agent, was immobilized within the pores of NH-MIL-101 (Fe) (FeMOFs) and on the surface of CuBTC crystallites (CuMOFs). MOFs were found to enhance the fluorescence emission and quench the PA intensity of biliverdin.

Cultivation in long-term simulated microgravity is detrimental to pyocyanin production and subsequent biofilm formation ability of .

Unlabelled: forms aggregates known as biofilms. Previous studies have shown that when is cultivated in space, thicker and structurally different biofilms are formed than from those grown on Earth. We investigated how microgravity, simulated in a laboratory setting, influenced the growth, colonization, and virulence potentials of a PA14 wild-type strain, as well as two surface attachment-defective () mutants altered at crucial biofilm-forming steps: and .

Neural mechanisms of inhibitory control in preadolescent irritability: Insights from the ABCD study.

Objective: Elevated pediatric irritability is a transdiagnostic symptom that predicts multiple mental health problems in adolescence and adulthood. Altered top-down regulatory networks, such as inhibitory control networks that suppress an impulse in favor of goal-directed behavior, are thought to contribute to high levels of youth irritability. Nevertheless, little work has examined links between youth irritability and neural processes supporting inhibitory control in large diverse samples, nor have they focused on the key period ramping up to adolescence (i.

Mechanistic insights into condensate formation of human liver-type phosphofructokinase by stochastic modeling approaches.

Human liver-type phosphofructokinase 1 (PFKL) has been shown to regulate glucose flux as a scaffolder arranging glycolytic and gluconeogenic enzymes into a multienzyme metabolic condensate, the glucosome. However, it has remained elusive of how phase separation of PFKL is governed and initiates glucosome formation in living cells, thus hampering to understand a mechanism of glucosome formation and its functional contribution to human cells. In this work, we developed a stochastic model in silico using the principle of Langevin dynamics to investigate how biological properties of PFKL contribute to the condensate formation.

Neighborhood environment and quality of life of older adults in eastern Nepal: findings from a cross-sectional study.

Introduction: Quality of life (QoL) is a subjective measure reflecting individuals' evaluations based on their personal goals and values. While global research shows the role of neighborhood factors like ethnic diversity and socio-cultural dynamics on QoL, these are unexplored in the Nepali context. Therefore, this study examined the relationship between neighborhood environment and QoL among Nepali older adults in eastern Nepal.