Robson ten group classification system for Caesarean sections across Europe: A systematic review and meta-analysis.

Unlabelled: The aim of this systemic review and meta-analysis was to examine the differences in caesarean section rates across European regions and at a country level by utilizing the Robson classification system. The study has compared caesarean rates across European regions using the Robson classification to identify the drivers of caesarean section use. This review shows significant variations in caesarean section rates across European regions, ranging from 16.

Therapeutic targeting potential of the protein lysine and arginine methyltransferases to reverse cancer chemoresistance.

Cancer treatments have continued to improve tremendously over the past decade, but therapy resistance is still a common, major factor encountered by patients diagnosed with cancer. Chemoresistance arises due to various circumstances and among these causes, increasing evidence has shown that enzymes referred to as protein methyltransferases (PMTs) play a significant role in the development of chemoresistance in various cancers. These enzymes are responsible for the methylation of different amino acids, particularly lysine and arginine, via protein lysine methyltransferases (PKMTs) and protein arginine methyltransferases (PRMTs), respectively.

Flexibility and Stability in Lexical Tone Recalibration: Evidence from Tone Perceptual Learning.

Listeners adjust their perception of sound categories when confronted with variations in speech. Previous research on speech recalibration has primarily focused on segmental variation, demonstrating that recalibration tends to be specific to individual speakers and situations and often persists over time. In this study, we present findings on the perceptual learning of lexical tone in Standard Chinese, a suprasegmental feature signaled primarily through pitch variations to distinguish morpheme/word meanings.

Comparison of Methods for Short-Segment Posterior Stabilization of Lumbar Spine Fractures and Thoracolumbar Junction.

: Thoracolumbar and lumbar spine injuries account for 30-60% of spinal fractures, especially at the thoracolumbar junction. Conservative treatment is recommended for stable fractures without neurological symptoms, but studies suggest surgical intervention may offer better outcomes. However, there is no consensus on the best stabilization method.

Successful Aging across Middle vs High-Income Countries: An Analysis of the Role of eHealth Literacy Associated with Loneliness and Wellbeing.

Background And Objectives: "Successful aging" concerns the process of growing older while maintaining physical, cognitive, and social wellbeing, emphasizing independence for overall satisfaction and quality of life. We investigate the impact of e-health literacy on reducing loneliness and sustaining wellbeing during the pandemic, comparing middle- and high-income countries.

Research Design And Methods: Online surveys were conducted between April 4, 2020, and September 30, 2021, collecting responses (N=2091) from medium- and high-income countries in Europe, Asia, and North America.

Validation of the Edinburgh Postnatal Depression Scale and its 3-item anxiety subscale, and the Generalised Anxiety Disorder-7 item for screening of postpartum depression and anxiety in women in Malta.

Background & Aim: Perinatal mental health disorders are common complications of pregnancy and the postpartum period. The value of screening for their early detection is well-recognized, but to-date, research-validated mental health measures for postpartum women in Malta are lacking. In this prospective cross-sectional study, we assessed the validity of the Edinburgh Postnatal Depression Scale (EPDS), an EPDS subscale (EPDS-3A), and the Generalised Anxiety Disorder-7 item (GAD-7) as screening measures for postpartum depression and anxiety.

Cross-Modal Cues Improve the Detection of Synchronized Targets during Human Foraging.

In two experiments, we explored whether cross-modal cues can be used to improve foraging for multiple targets in a novel human foraging paradigm. Foraging arrays consisted of a 6 × 6 grid containing outline circles with a small dot on the circumference. Each dot rotated from a random starting location in steps of 30°, either clockwise or counterclockwise, around the circumference.

A review of the genus Eugaster Serville, 1838 (Orthoptera, Tettigoniidae, Hetrodinae): a multifaceted approach.

Overall coloration, size and thoracic morphology have formed the basis for taxonomic differentiation of taxa within the genus Eugaster at specific or subspecific levels over the years. The present study employs a range of methods to examine the morphology of 58 specimens (18♂♂ and 40♀♀) from Morocco, Algeria and Tunisia, collected from altitudes varying between 10 and 1795 metres AMSL. Moroccan sampling sites include localities on both the north and south of the High Atlas and from either side of the Middle Atlas, i.

Wounds in a correctional facility in Malta: a point prevalence study.

Hard-to-heal (chronic) wounds are a challenge to wound care professionals, a burden to the health service and negatively impact affected individuals' quality of life. They also consume a great deal of healthcare resources globally and are found in all settings, including prisons. Therefore, the evaluation of wound care services is essential in order to develop an awareness of where improvement can be made.

The prevalence of threatened miscarriage in Malta.

A retrospective cohort study was conducted in Malta to assess the prevalence of threatened miscarriage. The study focuses on cases managed at a local state hospital over a 12-month period. Currently, data on pregnancies prior to 22 weeks' gestation are not publicly available, which hampers understanding of the frequency and impact of threatened miscarriage.

GameVibe: a multimodal affective game corpus.

As online video and streaming platforms continue to grow, affective computing research has undergone a shift towards more complex studies involving multiple modalities. However, there is still a lack of readily available datasets with high-quality audiovisual stimuli. In this paper, we present GameVibe, a novel affect corpus which consists of multimodal audiovisual stimuli, including in-game behavioural observations and third-person affect traces for viewer engagement.

International multi-cohort analysis identifies novel framework for quantifying immune dysregulation in critical illness: results of the SUBSPACE consortium.

Progress in the management of critical care syndromes such as sepsis, Acute Respiratory Distress Syndrome (ARDS), and trauma has slowed over the last two decades, limited by the inherent heterogeneity within syndromic illnesses. Numerous immune endotypes have been proposed in sepsis and critical care, however the overlap of the endotypes is unclear, limiting clinical translation. The SUBSPACE consortium is an international consortium that aims to advance precision medicine through the sharing of transcriptomic data.

Pharmacokinetics and Quantitative Structure-Pharmacokinetics Relationship Study of Xanthine Derivatives with Antidepressant, Anti-Inflammatory, and Analgesic Activity in Rats.

Objective: The aim of this study was to develop quantitative structure-pharmacokinetics relationship (QSPKR) models for a group of xanthine derivatives with proven pharmacological activity and to investigate its applicability for the prediction of the pharmacokinetics of these compounds.

Methods: The SYBYL-X, KowWin, and MarvinSketch programs were employed to generate a total of fourteen descriptor variables for a series of new compounds: 7- and 7,8-substituted theophylline derivatives (GR-1-GR-8) and three well-known methylxanthines. Pharmacokinetic profiles of all compounds were determined after intravenous administration of studied compounds to cannulated male rats.

Effect of the Lactation Phases on the Amplitude of Variation in Blood Serum Steroid Hormones and Some Hematochemical Analytes in Three Dairy Cow Breeds.

Lactation in dairy cows implies comprehensive endocrine and metabolic changes including a systemic electrolytic reaction. Previous studies have rarely considered these specific demands due to the influence of lactation periods. Therefore, this study aimed to assess the effects of early, middle, and late lactation phases on the dynamic changes in serum concentrations of progesterone (P4), 17β-oestradiol (E2), cortisol, and some electrolytes (Ca, Mg, Na, K, Cl, Pi) and biochemical parameters (alanine aminotransferase (ALT), aspartate aminotransferase (AST), lactate dehydrogenase (LDH), creatine kinase (CK), total bilirubin, urea, and iron (Fe) in 10 Holstein, 10 Brown Swiss, and 10 Modicana multiparous healthy dairy cows (4.

Modulation of Biological Membranes Using Small-Molecule Compounds to Counter Toxicity Caused by Amyloidogenic Proteins.

The transition of peptides or proteins along a misfolding continuum from soluble functional states to pathological aggregates, to ultimately deposit as amyloid fibrils, is a process that underlies an expanding group of human diseases-collectively known as protein-misfolding disorders (PMDs). These include common and debilitating conditions, such as Alzheimer's disease, Parkinson's disease, and type-2 diabetes. Compelling evidence has emerged that the complex interplay between the misfolded proteins and biological membranes is a key determinant of the pathogenic mechanisms by which harmful amyloid entities are formed and exert their cytotoxicity.

Stroke knowledge in Malta: A mixed methods study.

Background: Stroke is a major cause of morbidity and mortality worldwide. Despite advances in acute treatments, timely intervention remains crucial. This study assessed stroke knowledge in Malta to identify gaps that could contribute to treatment delays.