Influence of Azadirachta indica leaf extracts on tumor necrosis factor-α and interleukin-6 in albino rats and its computational analysis.

The current study was designed to investigate the effect of A. indica (Neem) leaf extracts (ethanolic and aqueous) in yeast-induced pyrexia and acetic acid-induced writhing in rat models to evaluate the antipyretic and analgesic biomarkers and its phytochemical screening with computational analysis. For the antipyretic activity model 60 albino rats (160-200g) of either sex were divided into 4 groups and all groups were injected with yeast to induce pyrexia.

Investigating the optimistic and therapeutic effects of wild grape: R. Parker.

R. Parker is a wild grape traditionally used by indigenous people as a substitute for cultivated grapes. However, its therapeutic effects have not been extensively studied.

Applications of T-spherical fuzzy aczel-alsina power muirhead mean operators in identifying the most effective water purification process for commercial purpose.

One of the key areas of research in ambiguous and inconsistent problems with decision-making is T-spherical multiple-attribute decision making (TP-FMADM). The TP-F number (TP-FN), which is an extension of the fuzzy number, an intuitionistic fuzzy number, and other fuzzy structures, may deal with problems involving a significant amount of incorrect, incomplete, and inconsistent data. Being an extension of various fuzzy structures, the TP-F sets (TP-FSs) provide decision-makers greater freedom to voice their actual opinions and offer a broader range of acceptable membership grades.

On modified Mittag-Leffler coupled hybrid fractional system constrained by Dhage hybrid fixed point in Banach algebra.

This research investigates the dynamics of nonlinear coupled hybrid systems using a modified Mittag-Leffler fractional derivative. The primary objective is to establish criteria for the existence and uniqueness of solutions through the implementation of Dhage's hybrid fixed-point theorem. The study further analyzes the stability of the proposed model.

Polyphenols and Their Biogenic Nano-Formulations Targeting BACE1 as Anti-Amyloid Therapies; Meeting the Challenges of Bioavailability, Safety, and Specificity for the Treatment of Alzheimer's Disease.

Alzheimer's disease (AD), a progressiveneurodegenerative condition is marked by extensive damage in the brain and dementia. Among the pathological hallmarks of AD is beta-amyloid (Aβ). Production of toxic Aβ oligomers production and accumulation in the brain is among the characteristic features of the disease.

Synthesis and Anti-Inflammatory and Analgesic Potentials of Ethyl 2-(2,5-Dioxo-1-Phenylpyrrolidin-3-yl)-2-Methylpropanoate.

: Inflammation and analgesia are two prominent symptoms and often lead to chronic medical conditions. To control inflammation and analgesia, many marketed drugs are in practice but the majority of them have severe side effects. : This study involved the synthesis of a pivalate-based Michael product and evaluated it for in vitro COX-1, COX-2, and 5-LOX inhibitory potentials using specific assays.

Probiotic significance of strains: a comprehensive review on health impacts, research gaps, and future prospects.

A rising corpus of research has shown the beneficial effects of probiotic on human health, contributing to the growing popularity of these microorganisms in recent decades. The gastrointestinal and urinary tracts are home to these bacteria, which play a vital role in the microbial flora of both humans and animals. The probiotic, i.

Putative Identification of 47 Compounds from Jieyu Anshen Granule and Proposal of Pharmacopeia Quality-Assessment Strategy Using TCM-Specific Library with UHPLC-Q-Exactive-Orbitrap-MS.

Jieyu Anshen Granule is a traditional Chinese medicine prescription used for depression and primarily comprises five herbal medicines: Zhizi, Chaihu, Zhigancao, Danggui, and Yuanzhi. This study established a traditional Chinese herbal medicine-specific library using emerging ultra-high-performance liquid chromatography-quadrupole-orbitrap-tandem mass spectrometry analysis. Through library comparison, the study has fulfilled isomers distinction.

Quantum Hall effect in a CVD-grown oxide.

Two-dimensional (2D) electron systems are promising for investigating correlated quantum phenomena. In particular, 2D oxides provide a platform that can host various quantum phases such as quantized Hall effect, superconductivity, or magnetism. The realization of such quantum phases in 2D oxides heavily relies on dedicated heterostructure growths.

Identification of genetic risk variants for Type-2 Diabetes mellitus in Pakistani Pashtun population: A case-control association study.

Background And Objective: Pakistan, a South Asian developing country, is experiencing a rapid increase in number of diabetes cases. High prevalence ratio of diabetes in Pakistani population and lack of genetic research studies prompted us to design this study. This present study investigated Pakistani Pashtun population for (known and novel SNPs) and its possible correlation with Type-2 Diabetes Mellitus (T2DM).

Bacterial nanocellulose production: Improvement in productivity and properties via a sustainable medium.

High production cost is a significant barrier to commercial bacterial nanocellulose (BNC) production. This study addresses this issue using a low-cost molasses and cheese whey medium via Gluconacetobacter hansenii. The one-factor-at-a-time method investigated the effect of critical factors on BNC production, including total sugar and total protein concentrations (g/L), initial pH, and additives such as ethanol and acetic acid (%(v/v)).

Estimation of genetic polymorphism in quince (Cydonia oblonga Mill.) genotypes using morphological traits and molecular (DNA barcoding) characterizations.

Quince (Cydonia oblonga) is a medicinal plant and a member of family Rosaceae. It is native plant of Asia Minor and Europe. It is used in production of jam and jellies and also as a remedy of several ailments.

Synthesis, Urease Inhibitory Activity, Molecular Docking, Dynamics, MMGBSA and DFT Studies of Hydrazone-Schiff Bases Bearing Benzimidazole Scaffold.

In this study, eleven hydrazone-Schiff bases bearing benzimidazole moiety were synthesized successfully via three step reactions and structures of these products were deduced by HR-ESI-MS, H-, and C-NMR spectroscopic techniques. Lastly, these derivatives were tested for their in vitro urease inhibitory potential. Six compounds among the series attributed excellent inhibition with IC values of 7.

Novel indole based fused triazole-thiadiazole derivatives as anti-diabetic agents: and approaches.

The current research presents novel library of indole derived fused triazole-thiadiazole derivatives (1-17) for treatment of diabetes mellitus. These compounds were synthesized by treating 2-(1H-indol-3-yl)acetic acid with hydrazinecarbothiohydrazide followed by treating the resultant compound with substituted benzoic acid. Structural validation was achieved spectroscopically (HNMR, CNMR and HREI-MS).

Pharmacogenomic Study of Selected Genes Affecting Amlodipine Blood Pressure Response in Patients with Hypertension.

Introduction: Despite the availability of various antihypertensive medications, the response to these medications varies among individuals. Understanding how individual genetic variations affect drugs treatment outcomes is a key area of focus in precision medicine. This study investigated the correlation between single nucleotide polymorphisms (SNPs) in selected genes (CACNA1C, CACNA1D, ABCB1, ACE, ADBR2, and NOS1AP) and the blood pressure (BP) control by amlodipine.

A simple and cost-effective hybrid stationary phase for the separation of peptides, proteins and benzene derivatives through liquid chromatography.

A very simple and cost-effective silica-based hybrid stationary phase was synthesized for the separation of five synthetic peptides, five proteins, and benzene derivatives. Silica monolith was synthesized sol-gel process. Particles obtained through the grinding of silica monolith were suspended in methanol and sedimented under gravity to obtain sub-2 μm particles.

Unveiling the potential of aluminum-decorated 3D phosphorus graphdiyne as a catalyst for NO reduction.

Interest in single-atom catalysts (SACs) has surged due to their potential to mitigate greenhouse NO gas from the environment. In this study, we explore the potential of NO reduction using porous 3D phosphorus graphdiyne decorated with an Al atom (3D-Al/PGDYN) through density functional theory. Results confirm the energetic stability of Al decorations on 3D-PGDYN and indicate that the Al atom plays an active role in catalysis.

Novel Anti-Tumor Effect of Natural Products from Aloe vera Resin and their In-Vitro/In-Silico Targeting Mechanism of Carbonic Anhydrase-II and IX.

Human carbonic anhydrase (hCA) plays a vital role in the development and progression of tumors in hypoxic conditions. Herein we report the hCA-II and hCA-IX activities of natural products isolated from Aloe vera (L.) Burm.

Synthesis of Novel Indolyl Aryl Sulfone-clubbed Hydrazone Derivatives as Potential HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors: Molecular Modeling and QSAR Studies.

Background: Non-Nucleoside Reverse Transcriptases Inhibitors (NNRTIs) are among the most extensively studied enzymes for understanding the biology of Human Immunodeficiency Viruses (HIV) and designing inhibitors for managing HIV infections. Indolyl aryl sulfones (IASs), an underexplored class of potent NNRTIs, require further exploration for the development of newer drugs for HIV.

Aims: In this context, we synthesized a series of novels by Indolyl Aryl Sulfones with a hydrazone moiety at the carboxylate site of the indole nucleus.

evaluation of favipiravir-associated potential new drugs against polymerase enzyme of SARS-CoV-2.

Millions of lives have been lost to the deadly SARS-CoV-2 virus. Vaccines and antiviral drugs are essential scientific tools in combating viral infections. This study focused on the RdRp inhibitor favipiravir, exploring new analogs by substituting the fluorine atom on the pyrazine ring with both homocyclic and heterocyclic moieties.

Investigating fractal fractional PDEs, electric circuits, and integral inclusions via (ψ,ϕ)-rational type contractions.

The fixed point theory has been generalized mainly in two directions. One is the extension of the spaces, and the other is relaxing and generalizing the contractions. This paper aims to establish novel fixed point results of rational type generalized -contractions in the context of extended b-metric spaces.

An empirical study for mitigating sustainable cloud computing challenges using ISM-ANN.

The significance of cloud computing methods in everyday life is growing as a result of the exponential advancement and refinement of artificial technology. As cloud computing makes more progress, it will bring with it new opportunities and threats that affect the long-term health of society and the environment. Many questions remain unanswered regarding sustainability, such as, "How will widely available computing systems affect environmental equilibrium"? When hundreds of millions of microcomputers are invisible to each other, what will society look like? What does this mean for social sustainability? This paper empirically investigates the ethical challenges and practices of cloud computing about sustainable development.

Enhancing Growth in through the Inhibition of Charcoal Rot Disease: A Strategic Approach Using Plant Growth-Promoting Rhizobacteria.

is a vital seed and soil-borne phytopathogen responsible for substantial crop yield losses. Although various methods exist for managing soil-borne pathogens, such as agronomic practices, chemical treatments, and varietal tolerance, biological control utilizing plant growth-promoting rhizobacteria (PGPR) or their secondary metabolites presents promising avenues. In this study, a screening of 150 isolates from the rhizosphere of L.

High-Precision Skin Disease Diagnosis through Deep Learning on Dermoscopic Images.

Dermatological conditions are primarily prevalent in humans and are primarily caused by environmental and climatic fluctuations, as well as various other reasons. Timely identification is the most effective remedy to avert minor ailments from escalating into severe conditions. Diagnosing skin illnesses is consistently challenging for health practitioners.