An Insight Into the Phytochemical Composition, Cardioprotective, and Antioxidant Characteristics of Small Knotweed ( R. Br.) Extract and Its Derived Fractions.

, a member of the Polygonaceae family, is commonly known as small knotweed and has been traditionally used to treat various ailments, including cough, gastrointestinal disorders, respiratory infections, liver disease, inflammation, dysentery, eczema and ringworms, and other skin conditions. Many studies have suggested that plants belonging to this genus possess strong cardio-protective potentials. Rats were pre-treated with crude methanolic extract and other fractions at a dose of 500 mg/kg followed by administration of Isoproterenol hydrochloride after 24 h for 2 days.

Influence of Azadirachta indica leaf extracts on tumor necrosis factor-α and interleukin-6 in albino rats and its computational analysis.

The current study was designed to investigate the effect of A. indica (Neem) leaf extracts (ethanolic and aqueous) in yeast-induced pyrexia and acetic acid-induced writhing in rat models to evaluate the antipyretic and analgesic biomarkers and its phytochemical screening with computational analysis. For the antipyretic activity model 60 albino rats (160-200g) of either sex were divided into 4 groups and all groups were injected with yeast to induce pyrexia.

Photovoltaic properties of halide perovskites for solar cell application with efficiency greater than 18.

The opto-electronic properties and solar cell efficiency of halide perovskites ALiInBr (A = Rb, Cs) are investigated using density functional theory (DFT) through WEIN2k and SCAPS-1D. The electronic characteristic of ALiInBr (A = Rb, Cs) compounds reveal their direct bandgap semiconductor nature and are active in visible rang. The results indicate that substituting Cs with Rb causes a slight narrowing of the bandgap.

The Prominence of the Broad-Spectrum Protease inhibitor gene A2ML1 as a potential biomarker in cervical cancer diagnostics using Immunotherapeutic and Multi-Omics approaches.

One of the venereal tumors that threaten human life is cervical cancer. A2ML1 is detected in advanced-stage cancer patients and is found to be strongly associated with cervical cancer. A2ML1 was shown to be substantially expressed in cervical cancer in this study, which used data from the TCGA database.

Exploring the aroma profile and biomedical applications of Scutellaria nuristanica Rech. F.: A new insight as a natural remedy.

Background: The Scutellaria genus has promising therapeutic capabilities as an aromatherapy. Based on that and local practices of S. nuristanica Rech.

Modeling different infectious phases of hepatitis B with generalized saturated incidence: An analysis and control.

Hepatitis B is one of the global health issues caused by the hepatitis B virus (HBV), producing 1.1 million deaths yearly. The acute and chronic phases of HBV are significant because worldwide, approximately 250 million people are infected by chronic hepatitis B.

Integrating 16S rRNA profiling and in-silico analysis for an epitope-based vaccine strategy against Achromobacter xylosoxidans infection.

Achromobacter xylosoxidans is an aerobic, catalase-positive, non-pigment-forming, Gram-negative, and motile bacterium. It potentially causes a wide range of human infections in cystic fibrosis and non-cystic fibrosis patients. However, developing a safe preventive or therapeutic solution against A.

Pregnenolone derivatives for the treatment of Alzheimer's disease: synthesis, and inhibition of amyloid β peptide aggregation, acetylcholinesterase and carbonic anhydrase-II.

The amyloid state, which is a specific conformation of proteins, offers valuable information about both functional protein structures and the pathological assemblies associated with various diseases. One of the major hallmarks of Alzheimer's disease includes primarily the extracellular build-up of a peptide known as amyloid-β, which has a sequence consisting of 39 to 42 amino acid residues, and the formation of intracellular neurofibrillary tangles mostly consisting of hyperphosphorylated tau protein. Drugs that are expected to reduce Aβ production, prevent Aβ aggregation, and promote Aβ clearance are promising approaches for treating AD.

Systematic surface bowing in 2D III-nitride monolayers.

In this article we report novel composite materials of bucky ball (C fullerene) and III-nitrides (BN, AlN, GaN, InN). The experimental feasibility of the novel composite materials is confirmed through negative binding energies and molecular dynamics simulations performed at 500 K. The structural properties of the novel composites are explored through density functional theory.

Vanillin derivatives as antiamnesic agents in scopolamine-induced memory impairment in mice.

Amnesia is a major health problem prevalent in almost every part of the world specifically in old age peoples. Vanillin analogues have played an important role in the field medicines. Some of them have been documented to be promising inhibitors of cholinesterases and could therefore, be used as antidepressant, anti-Alzheimer and as neuroprotective drugs.

Exopolysaccharide-producing bacterial cultures of and in soil augment water retention and maize growth.

Land productivity in arid and hot climate regions is constrained by water scarcity due to low rainfall and organic matter, which limit both soil-water retention and crop yields. Main objective of this research was to explore the potential of exopolysaccharide (EPS) producing bacteria screened from different soils for enhancing soil-water retention, phosphorus solubilization and maize growth. Twelve soil samples were drawn from diverse ecologies (sub-humid and arid) to isolate EPS-producing bacteria (EPB), and cultured on LB and Pikovskaya media.

Assessment of ubiquitin specific Peptidase-18 gene in peripheral blood of chronic hepatitis C patients treated with direct-acting antiviral drugs.

Hepatitis C virus (HCV) infection remains one of the leading causes of liver complications globally. Ubiquitin Specific Peptidase-18 () is a ubiquitin-specific protease that cleaves interferon-stimulated gene 15 (ISG15) from ISGylated protein complexes and is involved in regulating interferon responsiveness. To study the effect of direct-acting antivirals (DAAs) on the gene using qPCR, 132 participants were recruited and classified into different groups based on treatment duration.

Phyto-fabrication of ultrafine nanoscale holmium oxide HT-HoO NPs and their biomedical potential.

In this study holmium oxide nanoparticles (HoO NPs) are fabricated using extracts as a bioreductant. The XRD pattern of HT-HoO NPs (product from phyto-reduction) suggested that the nanoparticles are crystalline with no impurities. Scherrer approximation revealed grain sizes of ∼10 nm.

In silico explorations of bacterial mercuric reductase as an ecofriendly bioremediator for noxious mercuric intoxications.

Mercury is a major pollutant in the environment due to its high concentration in the soil. In this study, a mercuric reductase was extracted from Pseudomonas aeruginosa. The sequence of the enzyme was retrieved from the literature and structural homologs were identified.

Novel flurbiprofen clubbed oxadiazole derivatives as potential urease inhibitors and their molecular docking study.

In this study, twenty eight novel oxadiazole derivatives (5-32) of the marketed available non-steroidal anti-inflammatory drug (NSAID), ()-flurbiprofen (1), were synthesized I mediated cyclo-addition reaction in better yields. The synthesized hydrazone-Schiff bases were cyclized with iodine by using potassium hydroxide as a base in DMSO solvent to obtain oxadiazole derivatives (5-32). Structures of the synthesized products were confirmed with HR-ESI-MS, H-NMR spectroscopy and CHN analysis.

-Phenyl acrylamide-incorporated porous silica-bound graphene oxide sheets with excellent removal capacity for Cr(iii) and Cr(vi) from wastewater.

The sophisticatedly altered Hummer's and sol-gel procedures were applied for the synthesis of graphene oxides and porous silica monolith particles respectively. The Fischer esterification protocol was used for coupling silica monoliths with graphene oxides. A -phenyl acrylamide-incorporated porous polymer was synthesized at the surface of composites reversible addition fragmentation chain transfer polymerization.

Bio-oriented synthesis of ibuprofen derivatives for enhancement efficacy in post-operative and chronic inflammatory pain models.

The discovery of post-operative, chronic inflammatory pain and any gastroulcerogenic potential using well-established animal models with new structures, high efficiency, broad-spectrum, and low toxicity has been the focus of medicinal chemists. In the present article, we are reporting the design and synthesis of various derivatives of ibuprofen by modifying the carboxyl group of ibuprofen using three steps reactions; esterification under microwave-irradiation in 10 minutes, hydrazide formation, and finally schiff's base reaction. Microwave-assisted esterification reaction can be employed to quickly explore and increase molecular diversity in synthetic chemistry.

Nephroprotective effect of the hydromethanolic extract and fractions of Viola serpens Wall. Histological and hematological evidence.

The current study was planned to examine the nephroprotective effect of the crude extract and its various fractions of Viola serpense Wall against paracetamol-induced toxicity in rabbits. The serum creatinine levels of all fractions, as well as the crude extract, were found to have a greater effect. The effect on urine urea by the n-hexane, ethyl acetate, n-butanol and aqueous fraction in high doses (300 mg/kg b.

Analysis of food chain mathematical model under fractal fractional Caputo derivative.

In this article, the dynamical behavior of a complex food chain model under a fractal fractional Caputo (FFC) derivative is investigated. The dynamical population of the proposed model is categorized as prey populations, intermediate predators, and top predators. The top predators are subdivided into mature predators and immature predators.

Instability of modified Zakharov-Kuznetsov solitons in an inhomogeneous partially degenerate electron-ion magnetoplasma.

Linear and nonlinear propagation characteristics of multidimensional drift ion-acoustic (IA) solitons are studied in an inhomogeneous partially degenerate electron-ion magnetoplasma. A modified Zakharov-Kuznetsov (mZK) equation is deduced, accounting for the longitudinal as well as the transverse dispersions. It is shown that the mZK equation admits a distinct solution, revealing excitation of a pulse-shaped soliton when the phase speed exceeds by the wave dispersion.

Two-dimensional van der Waals heterostructures (vdWHs) with band alignment transformation in multi-functional devices.

Two-dimensional van der Waals heterostructures (vdWHs) with tunable band alignment have the potential to be benignant in the development of minimal multi-functional and controllable electronics, but they have received little attention thus far. It is crucial to characterize and control the band alignment in semiconducting vdWHs, which determines the electronic and optoelectronic properties. The future success of optoelectronic devices will require improved electronic property control techniques, such as using an external electric field or strain engineering, to change the electronic structures directly.

Heat transfer analysis: convective-radiative moving exponential porous fins with internal heat generation.

The efficiency, temperature distribution, and temperature at the tip of straight rectangular, growing and decaying moving exponential fins are investigated in this article. The influence of internal heat generation, surface and surrounding temperatures, convection-conduction, Peclet number and radiation-conduction is studied numerically on the efficiency, temperature profile, and temperature at the tip of the fin. Differential transform method is used to investigate the problem.