Olfactory Identification as a Biomarker for Cognitive Impairment: Insights from Healthy Aging, Subjective Cognitive Decline, and Mild Cognitive Impairment.

: This study aims to investigate the relationship between olfactory identification (OI) and cognitive impairment by examining OI abilities across various stages of cognitive deterioration. : A total of 264 participants were divided into three groups based on cognitive status: cognitively healthy, subjective cognitive, and mild cognitive impairment. All participants were assessed using the Sniffin' Sticks Olfactory Identification test and a comprehensive neuropsychological test battery.

Effectiveness of switching strategies in CGRP monoclonal antibody therapy for migraine: A retrospective cohort study.

Objective: To evaluate the effectiveness of first switching between monoclonal antibodies (mAbs) targeting calcitonin gene-related peptide (CGRP) or its receptor in the treatment of migraine.

Background: Although mAbs targeting CGRP or its receptor have emerged as a leading treatment for migraine prevention, a proportion of patients do not respond. While switching between these antibodies is a common clinical practice in such cases, the effectiveness remains a subject of study.

Addressing durability in collaborative organising: Event atmospheres and polyrhythmic affectivity.

Collaborative organising is known to burn like a rocket: it thrives on intense passion, relationality and creativity but quickly falls into pieces. This article explores the underestimated role of events and their affective atmospheres to sustain collaborative work. Drawing insights from two ethnographic field studies within an open-source software community and a network of impact entrepreneurs, we introduce the notion of 'polyrhythmic affectivity' at the core of polycentric governance.

Melatonin stabilizes atherosclerotic plaques: an association that should be clinically exploited.

Atherosclerosis is the underlying factor in the premature death of millions of humans annually. The cause of death is often a result of the rupture of an atherosclerotic plaque followed by the discharge of the associated molecular debris into the vessel lumen which occludes the artery leading to ischemia of downstream tissue and to morbidity or mortality of the individual. This is most serious when it occurs in the heart (heart attack) or brain (stroke).

Identification of putative volatile biomarkers of canine leishmaniasis in dog's breath and hair employing a novel algorithm for automated chromatographic peak detection and matching.

The analysis of the volatile compounds released by biological samples represents a promising approach for the non-invasive diagnosis of a disease. The present study, focused on a population of dogs infected with canine leishmaniasis, aimed to decipher the volatolomic profile associated with this disease in dogs, which represent the main animal reservoir for Leishmania pathogen transmission to humans. The volatiles emitted by the breath and hair of dogs were analysed employing the gas chromatography-mass spectrometry (GC-MS) technique.

Reprogramming tumor-associated macrophages with lipid nanosystems reduces PDAC tumor burden and liver metastasis.

Background: Pancreatic ductal adenocarcinoma (PDAC) requires innovative therapeutic strategies to counteract its progression and metastatic potential. Since the majority of patients are diagnosed with advanced metastatic disease, treatment strategies targeting not only the primary tumor but also metastatic lesions are needed. Tumor-Associated Macrophages (TAMs) have emerged as central players, significantly influencing PDAC progression and metastasis.

Enhancing wine fermentation through concurrent utilization of and lactic acid bacteria ( and ) or .

Most commercially available red wines undergo alcoholic fermentation by yeasts, followed by a second fermentation with the lactic acid bacteria once the initial process is complete. However, this traditional approach can encounter complications in specific scenarios. These situations pose risks such as stalled alcoholic fermentation or the growth of undesirable bacteria while the process remains incomplete, leaving residual sugars in the wine.

Tiny but mighty? Overview of a decade of research on nectar bacteria.

An emerging focus of research at the intersection of botany, zoology, and microbiology is the study of floral nectar as a microbial habitat, referred to as the nectar microbiome, which can alter plant-pollinator interactions. Studies on these microbial communities have primarily focused on yeasts, and it was only about a decade ago that bacteria began to be studied as widespread inhabitants of floral nectar. This review aims to give an overview of the current knowledge on nectar bacteria, with emphasis on evolutionary origin, dispersal mode, effects on nectar chemistry and plant-animal interactions, community assembly, agricultural applications, and their use as model systems in ecological research.

Effect of hydrophobic proteins in modulating the mechanical properties of lung surfactant membranes.

Pulmonary surfactant is a membranous complex that enables breathing dynamics at the respiratory surface. Extremely low values of surface tension are achieved at end-expiration thanks to a unique mixture of lipids and proteins. In particular, the hydrophobic surfactant proteins, specially the protein SP-B, are crucial for surfactant biophysical function, in order to provide the surfactant lipid matrix with the ability to form membranous multi-layered interfacial films that sustain optimal mechanical properties.

Worldwide comparison of carbon stocks and fluxes between native and non-native forests.

Climate change is one of the main challenges that human societies are currently facing. Given that forests represent major natural carbon sinks in terrestrial ecosystems, administrations worldwide are launching broad-scale programs to promote forests, including stands of non-native trees. Yet, non-native trees may have profound impacts on the functions and services of forest ecosystems, including the carbon cycle, as they may differ widely from native trees in structural and functional characteristics.

Possible link between the preferential unilateral chewing side and eruptive guidance of the maxillary canine germ : Cross-sectional study on panoramic radiographs.

Aim: To determine whether unilateral preferent chewing (UPC) affects the position and angulation of the permanent maxillary canine germ on the preferred side.

Materials And Methods: In a retrospective cross-sectional study, medical records from children 7.91(± 0.

Model organisms for investigating the functional involvement of NRF2 in non-communicable diseases.

Non-communicable chronic diseases (NCDs) are most commonly characterized by age-related loss of homeostasis and/or by cumulative exposures to environmental factors, which lead to low-grade sustained generation of reactive oxygen species (ROS), chronic inflammation and metabolic imbalance. Nuclear factor erythroid 2-like 2 (NRF2) is a basic leucine-zipper transcription factor that regulates the cellular redox homeostasis. NRF2 controls the expression of more than 250 human genes that share in their regulatory regions a cis-acting enhancer termed the antioxidant response element (ARE).

The scent of habitat shift: Olfactory receptor evolution is associated with environmental transitions in turtles.

The transition between aquatic and terrestrial habitats leads to extreme structural changes in sensorial systems. Olfactory receptors (OR) are involved in the detection of odorant molecules both in water and on land. Therefore, ORs are affected by evolutionary habitat transitions experienced by organisms.

Demethylation Inhibitor Fungicides Have a Significantly Detrimental Impact on Population Growth and Composition of Nectar Microbial Communities.

Demethylation inhibitor (DMI) fungicides are a mainstay of modern agriculture due to their widespread use for crop protection against plant-pathogenic fungi. However, DMI residues can disperse and persist in the environment, potentially affecting non-target fungi. Previous research has demonstrated that DMIs and other fungicides inhibit yeast growth in floral nectar microbial communities and decrease fungal richness and diversity of exposed flowers with no apparent effect on bacteria.

Diet influence on male sexual maturation through interplay between insulin signaling and juvenile hormone in insects.

In animals, sexual maturation coincides with the development of sexual behaviors and reproductive system. These developmental events are influenced by diet and governed by endocrine signals. Here, for the first time in insects, we explored functional links between nutrition and juvenile hormone (JH) in the male reproductive physiology through the insulin signaling pathway (ISP) acting as a transducer of nutritional signals.

Can triad forestry reconcile Europe's biodiversity and forestry strategies? A critical evaluation of forest zoning.

Balancing increasing demand for wood products while also maintaining forest biodiversity is a paramount challenge. Europe's Biodiversity and Forest Strategies for 2030 attempt to address this challenge. Together, they call for strict protection of 10% of land area, including all primary and old growth forests, increasing use of ecological forestry, and less reliance on monocultural plantations.

Internet gaming disorder and the alternative five factor personality model: a study in a Spanish community sample.

Background: This study was designed to examine the prevalence and relationships between the Internet gaming disorder (IGD) behaviors, suggested by the Diagnostic and Statistical Manual of Mental Disorders (DSM-5), and personality traits.

Participants And Procedure: A sample community of 1,548 subjects, 707 men and 841 women, with a mean age of 40.90 and 38.

The effect of fabrication procedures and thermomechanical loading on the structural properties of screw-retained metal-ceramic implant restorations: An in vitro study.

Purpose: Metal-ceramic screw-retained implant restorations persist as a fundamental choice in specific clinical scenarios. Little is known about the effects of fabrication steps and aging on their structural properties. This study aimed to investigate how laboratory fabrication procedures and thermomechanical loading affect the structural properties of screw-retained metal-ceramic implant restorations.

Bifidobacterium longum CECT 30763 improves depressive- and anxiety-like behavior in a social defeat mouse model through the immune and dopaminergic systems.

Adolescence is a crucial period marked by profound changes in the brain. Exposure to psychological stressors such as bullying, abuse or maltreatment during this developmental period may increase the risk of developing depression, anxiety and comorbid cardiometabolic conditions. Chronic psychological stress is associated with behavioral changes and disruption of the hypothalamic-pituitary-adrenal axis, leading to corticosterone overproduction in rodents and changes in both the immune system and the gut microbiome.

Moral sensitivity of nursing students: Adaptation and validation of the Campillo's tool.

Aim: Analyse the psychometric properties of the Moral Sensitivity Questionnaire in nursing care and to examine the level of moral sensitivity among nursing students in Spain.

Background: Ethical sensitivity is essential in nursing for patient care and decision-making. Assessing nursing students' moral sensitivity aids in developing training strategies for improved care.

Particle transport in open polygonal billiards: A scattering map.

Polygonal billiards exhibit a rich and complex dynamical behavior. In recent years, polygonal billiards have attracted much attention due to their application in the understanding of anomalous transport, but also at the fundamental level, due to their connections with diverse fields in mathematics. We explore this complexity and its consequences on the properties of particle transport in infinitely long channels made of the repetitions of an elementary open polygonal cell.

Pregnancy and Infant Outcomes in Women With Multiple Sclerosis Treated With Ocrelizumab.

Background And Objectives: Ocrelizumab labeling advises contraception for women during treatment and for 6-12 months thereafter. Because pregnancies may occur during this time, it is critical to understand pregnancy and infant outcomes in women with multiple sclerosis (MS) after ocrelizumab exposure.

Methods: Pregnancy cases reported to Roche global pharmacovigilance until 12 July 2023 were analyzed.

Work-Related Musculoskeletal Disorders in Physical Therapists: A Cross-Sectional Study.

Physical therapists, because of their care work, are susceptible to work-related musculoskeletal disorders due to their caregiving duties. These disorders have a significant economic and social impact. To analyze the prevalence of work-related musculoskeletal disorders among physical therapists and their associated factors.