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University of Madras)[Affiliation] Publications | LitMetric

4,171 results match your criteria: "University of Madras)[Affiliation]"

This article discusses a finite-source stock-dependent stochastic inventory system with multiple servers and a retrial facility. The system can store a maximum of S items, and the lifetime of each item is exponentially distributed. The primary customer arrives at the waiting hall from the finite source and receives service from multi-servers.

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Two new phenyl-sulfonyl-indole derivatives, namely, -{[3-bromo-1-(phenyl-sulfon-yl)-1-indol-2-yl]meth-yl}--(4-bromo-3-meth-oxy-phen-yl)benzene-sulfonamide, CHBrNOS, (), and ,-bis-{[3-bromo-1-(phenyl-sulfon-yl)-1-indol-2-yl]meth-yl}benzene-sulfonamide, CHBrNOS, (), reveal the impact of intra-molecular π-π inter-actions of the indole moieties as a factor not only governing the conformation of ,-bis-(1-indol-2-yl)meth-yl)amines, but also significantly influencing the crystal patterns. For , the crystal packing is dominated by C-H⋯π and π-π bonding, with a particular significance of mutual indole-indole inter-actions. In the case of , the mol-ecules adopt short intra-molecular π-π inter-actions between two nearly parallel indole ring systems [with the centroids of their pyrrole rings separated by 3.

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Salt-inducible kinases (SIKs) in cancer: mechanisms of action and therapeutic prospects.

Drug Discov Today

December 2024

Cell Signaling and Cancer Biology Laboratory, Department of Biochemistry, Guindy Campus, University of Madras, Chennai 600025, India. Electronic address:

Salt-inducible kinases (SIKs), a group of serine/threonine kinases in the adenosine monophosphate-activated protein kinase (AMPK) family, exist in three isoforms: SIK1, SIK2 and SIK3. These kinases are crucial in various physiological processes. Emerging evidence indicates that dysregulation of SIK expression and activation significantly contributes to carcinogenesis by promoting cellular proliferation, metabolic dysregulation, metastasis and chemoresistance through the modulation of crucial signaling pathways.

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Evaluating value-added biochemical and biodiesel production from Chlorococcum humicolo algal biomass in phycoremediation of textile dye effluents.

Bioresour Technol

December 2024

Department of Biotechnology, Sathyabama Institute of Science and Technology, Deemed to be University, Chennai 600 119, Tamil Nadu, India.

This study investigates the potentials of Chlorococcum humicolo algal biomass for the extraction of valuable biochemical and biodiesel production, with focus on the phycoremediation of textile dye effluents. The alga was cultivated in three media: CFTRI medium, combined dye effluent, and dye bath effluent in the laboratory. The highest cell count (254 × 10 cells/ml) and lowest oil content (16.

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A pilot study on the efficacy of a telomerase activator in regulating the proliferation of A375 skin cancer cell line.

Mol Biol Rep

December 2024

Department of Genetics, Dr. ALM PG Institute of Basic Medical Sciences, University of Madras, Taramani Campus, Chennai, Tamilnadu, 600113, India.

Introduction: The changes in histone modifications are linked to the progression of benign and normal tissue to malignancy. Thus, numerous findings suggest that targeting epigenetic factors might be a focus for anti-cancer treatment. In this study, we tested the hypothesis that telomerase activator might be a potential epigenetic regulator in combatting skin cancer cell proliferation.

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Heterogeneous photocatalysis has been widely explored as a promising solution for dye degradation due to its cost-effectiveness, ease of recovery, and use of green technology. Precisely, iron-doped cadmium sulfide (CdS) exhibits greater efficiency because of its higher charge separation, more electron transfer efficiency, and adsorption under visible region. In this study, two different ratios of iron-doped cadmium sulfide (CdFeS/GO) nanocomposites such as CdFeS/GO and CdFeS/GO were synthesized using the coprecipitation method and characterized with UV-Vis DRS, XRD, FT-IR, Raman, XPS, and HR-TEM.

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Unlabelled: The emergence of multidrug resistance in pathogenic organisms has caused growing concern, especially among healthcare providers, necessitating the development of new antimicrobial compounds. Resistance to metal nanoparticles is more challenging for any pathogen and thus paved a new avenue of research to formulate a new line of drugs combined with metal nanoparticles to treat microbial resistance. In this present investigation, green synthesised silver (AgNP), gold (AuNP), and platinum (PtNP) nanoparticles using the rind extract of the fruit of Garcinia mangostana L.

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Article Synopsis
  • Carbon quantum dots (CQDs) derived from Walnut Shell biomass have been studied as effective fluorescent sensors for detecting Acebrophylline (AB), a medication for respiratory diseases.
  • The CQDs exhibit high selectivity and sensitivity towards AB, with a detection limit of 0.142 nM and strong performance in human urine samples, achieving recovery rates between 81 to 123%.
  • The study also analyzed structural changes in CQDs after sensing AB and explored the effects of various factors on detection, emphasizing the method's eco-friendly and cost-effective potential for healthcare applications.
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Rational design of NiCoO@carbon hollow spheres as a high-performance electrode material for flexible supercapacitors.

Nanoscale

December 2024

Functional Nano-Materials (FuN) Laboratory, Department of Physics and Nanotechnology, Faculty of Engineering and Technology, SRM Institute of Science and Technology, Kattankulathur - 603203, India.

The design of innovative, flexible electrode materials with high electrochemical performance is critical for the development of next-generation supercapacitors. Here, we report the rational synthesis of NiCoO@carbon hollow spheres, engineered a metal-organic framework (MOF)-templated strategy, as a high-performance electrode material for flexible supercapacitors. The unique hollow structure of NiCoO@carbon enhances ion accessibility and electron transport, while the carbon layer provides structural stability and conductivity, significantly boosting energy storage capabilities.

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Endocrine-disrupting chemicals (EDCs) play an important role in the incidence of type-2 diabetes. Di-2-ethyl hexyl Phthalate (DEHP) is one of the endocrine-disrupting chemicals used as a plasticizer to impart flexibility and softness to plastic-containing materials. Mono-2-ethylhexyl Phthalate (MEHP), a DEHP's primary metabolite, is preferentially absorbed once metabolized.

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GPR55, an orphan GPCR, holds significance in the context of neurological disorders and its activation is important for regulating neurological responses. This has led us to uncover and explore a set of ligands which may act as potential agonists. We have predicted the GPR55 structural model followed by molecular docking, dynamics simulation studies, free energy landscape and MMPBSA analyses to study the dynamic nature of GPR55 in the presence of different ligands.

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This study focuses on the development of biomaterials for bone regeneration highlighting 59S bioactive glass (59S BG), tri-calcium phosphate (TCP), and their 1:1 composite (59S BG/TCP). The synthesized materials demonstrated excellent properties for bone tissue engineering. Characterization revealed their thermal stability up to 900 °C, as confirmed by thermogravimetric analysis (TGA), while X-ray diffraction (XRD) identified calcium phosphate and silicate phases.

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Radiation doses received by humans in their dwellings - A baseline report on radionuclides exposure from construction materials used in Chennai, Tamil Nadu, India.

J Hazard Mater

December 2024

Unit of Research in Radiation Biology & Environmental Radioactivity (URRBER), P.G. & Research Department of Zoology, The New College (Autonomous), Affiliated to University of Madras, Chennai, Tamil Nadu 600 014, India. Electronic address:

Gamma-ray spectrometry was employed to assess the activity concentrations of primordial radionuclides (U, Th, and K) in various construction materials, including those used for building, roofing, furnishing, flooring, and plastering. The measured activity concentrations of the radionuclides ranged as follows: U (25 to 477 Bq kg), Th (below detection limit to 239 Bq kg), and K (285 to 1915 Bq kg). Based on these values, the materials were categorized in descending order of radioactivity threat as: Furnishing > Roofing > Building > Flooring > Plastering.

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Preclinical liver toxicity models: Advantages, limitations and recommendations.

Toxicology

December 2024

Department of Pharmacology and Environmental Toxicology, Dr. A.L.M. Postgraduate Institute of Basic Medical Sciences, University of Madras, Chennai, India.

Experimental animal models are crucial for elucidating the pathophysiology of liver injuries and for assessing new hepatoprotective agents. Drugs and chemicals such as acetaminophen, isoniazid, valproic acid, ethanol, carbon tetrachloride (CCl), dimethylnitrosamine (DMN), and thioacetamide (TAA) are metabolized by the CYP2E1 enzyme, producing hepatotoxic metabolites that lead to both acute and chronic liver injuries. In experimental settings, acetaminophen (centrilobular necrosis), carbamazepine (centrilobular necrosis and inflammation), sodium valproate (necrosis, hydropic degeneration and mild inflammation), methotrexate (sinusoidal congestion and inflammation), and TAA (centrilobular necrosis and inflammation) are commonly used to induce various types of acute liver injuries.

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Creatinine is indeed a crucial biomarker for kidney diseases. In this work, a novel electrochemical biosensor based on a copper-hemin metal organic framework [Cu-hemin metal-organic framework (MOF)] nanoflake decorated with palladium (Pd) (Pd/Cu-hemin MOF) was fabricated and incorporated with creatinine deiminase (CD) on a glassy carbon electrode (GCE) for creatinine detection. The formation of a Pd/Cu-hemin MOF composite was confirmed by X-ray photoelectron spectroscopy, X-ray diffraction, and Fourier transform infrared spectroscopy.

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The identification of individuals with the greatest risk of progression to active tuberculosis (TB) disease from the huge reservoir of () infected individuals continues to remain an arduous ascent in the global effort to control TB. In a two-year prospective study, we analysed metabolic profiles in the unstimulated and TB antigen stimulated QuantiFERON supernatants of 14 healthy household contacts (HHCs) who progressed to TB disease (Progressors) and 14 HHCs who remained healthy (Non-Progressors). We identified 21 significantly dysregulated metabolites in the TB antigen-stimulated QuantiFERON supernatants of Progressors, of which the combination of Malic acid and N-Arachidonoylglycine had maximum AUC of 0.

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Biophysical characterization and in silico analysis of natural and synthetic compounds targeting Listeria monocytogenes HtrA protease.

Mol Divers

November 2024

Centre of Advanced Study in Crystallography and Biophysics, University of Madras, Guindy Campus, Chennai, 600 025, India.

HtrA protein is a member of a serine protease family with dual functions as a protease and molecular chaperone. It is a virulence factor in many bacteria, including the food-borne pathogen Listeria monocytogenes (Lm), which induces listeriosis in humans. Hence, inhibitors of LmHtrA protease have great importance in the control of infection.

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Biosurfactant based biostimulants plays a vital role in agriculture filed by enhancing the soil quality, promote plant growth, and eliminate plant pathogens, and increasing nutrient uptake. This manuscript describes the synthesis of trimesic based lithocholic ester functionalized amphiphiles (TMLCEA) with oppositely charged head groups using thiol-yne click chemistry, which is an effective and simple approach. The trimesic based lithocholic ester functionalized zwitterionic penicillamine (TMLCEPA), cationic cysteamine·HCl (TMLCECy), and anionic thiomalic acid (TMLCETM) exhibited hierarchically self-assembled microstructures from below to above the CMC.

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Four salicylidene-based dual-responsive chemosensors 1,5-bis(5-bromosalicylaldehyde)carbohydrazone (R1), 1,5-bis(5-bromosalicylaldehyde)thiocarbohydrazone (R2), 1,5-bis(3-ethoxysalicylaldehyde)carbohydrazone (R3) and 1,5-bis(3-ethoxysalicylaldehyde)thiocarbohydrazone (R4) were synthesized and characterized. The molecular structures of R1 and R3 were confirmed by single crystal X-ray diffraction technique, which crystallized in the orthorhombic and monoclinic 2/ space groups, respectively. The chemosensor molecules were investigated for their recognition properties against the selected cations (K, Ca, Mn, Co, Ni, Cu, Zn, Fe and Al) and anions (F, Cl, Br, I, HSO, HPO, ClO, N and NO) by colorimetry, absorption spectroscopy, fluorescence spectroscopy, H NMR spectroscopy and theoretical studies.

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Functional characterization of Staphylococcus aureus lipase 2 (SAL2) as a collagen adhesin.

Biophys Chem

February 2025

Centre of Advanced Study in Crystallography and Biophysics, University of Madras, Guindy Campus, Chennai 600 025, India. Electronic address:

Extracellular lipases of many pathogens have been characterized as human virulence factors. Staphylococcus aureus produces a variety of enzymes that aid in the pathogenesis of the bacterium to invade and destroy host tissues, resulting in a wide range of clinical illnesses. The lipase is one such enzyme, and the lipases produced by S.

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Our research aims to design novel pyrimidine derivatives inspired by the common pyrimidine core found in many FDA-approved drugs. However, extensive prior research on the pyrimidine scaffold has made discovering new molecules more challenging. To overcome this obstacle, we employed a molecular hybridisation strategy, opting to hybridise tetralin and pyrimidine, recognising their potential in cancer therapeutics.

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Antibacterial Activity, GC MS Analysis and In Silico Validation of Bioactive Compound from Endophytic Fungus Lasiodiplodia pseudotheobromae EF-9.

Chem Biodivers

November 2024

PG & Research Department of Biotechnology, Sri Sankara Arts and Science College, University of Madras, Enathur, Kanchipuram, Tamil Nadu, 631 561, India.

Secondary metabolites synthesized by endophytic fungi have garnered significant interest for their broad applications in treating various ailments. In this study involving 20 plant samples, 11 endophytic fungi were isolated and cultured, and Lasiodiplodia pseudotheobromae EF-9, derived from Hibiscus rosa-sinensis, demonstrated greater antibacterial efficacy than the other isolated endophytes. Phylogenetic analyses using 18S rRNA gene confirmed the EF-9 identity as L.

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Effect of hinokitiol in ameliorating oral cancer: in vitro and in silico evidences.

Odontology

November 2024

Department of Microbiology, Dr. ALM Post Graduate Institute of Basic Medical Science, University of Madras, Chennai, Tamil Nadu, 600113, India.

The study aimed to evaluate the anticancer potential of hinokitiol in treating oral cancer by using in vitro models and examining its interaction with the Pim-1 protein through in silico methods. Hinokitiol was applied to KB-1 oral squamous carcinoma cells, where the half-maximal inhibitory concentrations (IC) was determined. Morphologic changes in treated cells were observed using phase contrast microscopy, while acridine orange/ethidium bromide (AO/EB) staining was used to assess nuclear changes and apoptosis.

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Demonstrating the potential of bioactive glass-infused electrospun PVB fibrous patches in atopic dermatitis moisturizing therapy.

Int J Pharm

December 2024

National Centre for Nanoscience and Nanotechnology, University of Madras, Guindy Campus, Chennai 600 025, India. Electronic address:

Atopic dermatitis (AD) is a prevalent chronic inflammatory skin disorder characterized by pruritic and eczematous lesions. Current treatment modalities often focus on symptomatic relief through topical moisturizers to restore impaired skin barrier function. Bioactive glasses, such as 45S5 and 59S compositions, have gained attention for their potential therapeutic applications in dermatological conditions due to their biocompatibility, bioactivity, and ability to promote wound healing.

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Background: Polycystic ovary syndrome (PCOS) is a common metabolic/ endocrine disorder seen predominantly in women in their reproductive age, which increases the risk of infertility, endometrial cancer and metabolic disorders. IL-27 and IL-38 are recently discovered, novel anti-inflammatory cytokines whose role in immune-endocrine dysfunction seen in PCOS is largely unknown.

Methods: In the present study, we quantified these two cytokines along with markers for meta-inflammation (TNF-α, IL-6, IL-1β, IL-1Ra, IL-10 and TGF-β) and hormonal dysregulation (insulin, leptin, adiponectin, FGF-21, testosterone and DHEA-S) in the serum of PCOS women (n=44), along with age matched controls (n=20), by ELISA.

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