44 results match your criteria: "University of Madison Wisconsin[Affiliation]"

Introduction: Integrating community expertise into scientific teams and research endeavors can holistically address complex health challenges and grand societal problems. An in-depth understanding of the integration of team science and community engagement principles is needed. The purpose of this scoping review was to identify how and where team science and community engagement approaches are being used simultaneously in research.

View Article and Find Full Text PDF

Background: Enhanced Recovery Pathways (ERPs) have enabled safe same day discharge (SDD) of select patients after elective minimally invasive colectomy. We aimed to analyse the financial impact of SDD in these cases.

Methods: We queried the Nationwide Readmission Database (2016-2019) and included patients with a hospital length of stay ≤2 days after minimally invasive elective colectomy.

View Article and Find Full Text PDF
Article Synopsis
  • The study investigates the effects of TCDD, an environmental toxin, on zebrafish, focusing on skeletal issues, growth, and behavior in both juvenile and their F offspring.
  • Transgenerational exposure to TCDD at specific developmental stages led to noticeable changes in morphology and behavior in the adult fish, with males showing a brief compensation in growth.
  • The F offspring displayed hyperactivity and various health issues, such as edema and skeletal abnormalities, indicating that the impact of TCDD is both immediate and affects future generations.
View Article and Find Full Text PDF

Adaptation of the Mycobacterium tuberculosis transcriptome to biofilm growth.

PLoS Pathog

April 2024

Department of Medical Microbiology and Immunology, School of Medicine and Public Health, University of Madison-Wisconsin, Madison, Wisconsin, United States of America.

Mycobacterium tuberculosis (M. tb), the causative agent of tuberculosis (TB), is a leading global cause of death from infectious disease. Biofilms are increasingly recognized as a relevant growth form during M.

View Article and Find Full Text PDF

Introduction: Use of adeno-associated virus (AAV) vectors is complicated by host immune responses that can limit transgene expression. Recent clinical trials using AAV vectors to deliver HIV broadly neutralizing antibodies (bNAbs) by intramuscular administration resulted in poor expression with anti-drug antibodies (ADA) responses against the bNAb.

Methods: Here we compared the expression of, and ADA responses against, an anti-SIV antibody ITS01 when delivered by five different AAV capsids.

View Article and Find Full Text PDF

The objective of this study was to describe the clinical signs, neurologic examination findings, diagnostic imaging results, and pathologic diagnosis of ossifying fibroma in the cervical vertebra of a dog. A 3-year-old spayed female Pembroke Welsh corgi dog exhibited severe cervical pain and left-sided postural reaction deficits. Magnetic resonance imaging (MRI) revealed a lobulated contrast enhancing mass associated with the C6 cervical vertebra.

View Article and Find Full Text PDF

Caves have long been recognized as a window into the mechanisms of diversification and convergent evolution, due to the unique conditions of isolation and life in the dark. These lead to adaptations and reduce dispersal and gene flow, resulting in high levels of speciation and endemism. The Israeli cave arachnofauna remains poorly known, but likely represents a rich assemblage.

View Article and Find Full Text PDF

Background: Networks are critical for leadership development, but not all networks and networking activities are created equally. Women and people of color face unique challenges accessing networks, many of which were exacerbated during the COVID-19 pandemic. Virtual platforms offer opportunities for global professionals to connect and can be better tailored to meet the needs of different groups.

View Article and Find Full Text PDF

Caves constitute ideal study systems for investigating adaptation and speciation, as the abiotic conditions shared by aphotic habitats exert a set of environmental filters on their communities. Arachnids constitute an important component of many cave ecosystems worldwide. We investigated the population genomics of two whip spider species: Sarax ioanniticus, a widely distributed parthenogenetic species found across the eastern Mediterranean; and S.

View Article and Find Full Text PDF

New Caledonia has an endemic opiliofauna with two named species of Triaenonychidae, 17 Troglosironidae and eight Zalmoxidae. The recent finding of Neopilionidae on Grande Terre was thus surprising, and required the formal description of a new genus, which we undertake here. Martensopsalis gen.

View Article and Find Full Text PDF

The extensive and functionally uncharacterized mitochondrial phosphoproteome.

J Biol Chem

July 2021

Departments of Cell Biology and Physiology, Biochemistry & Molecular Biophysics, and Genetics, Washington University in St Louis, St Louis, Missouri, USA; Morgridge Institute for Research, Madison, Wisconsin, USA; Department of Biochemistry, University of Madison-Wisconsin, Madison, Wisconsin, USA. Electronic address:

More than half a century ago, reversible protein phosphorylation was linked to mitochondrial metabolism through the regulation of pyruvate dehydrogenase. Since this discovery, the number of identified mitochondrial protein phosphorylation sites has increased by orders of magnitude, driven largely by technological advances in mass spectrometry-based phosphoproteomics. However, the majority of these modifications remain uncharacterized, rendering their function and relevance unclear.

View Article and Find Full Text PDF

Background: The Final Rule of the Healthy Hunger Free Kids Act, published in 2016, required school districts participating in the federal Child Nutrition Programs to update their local wellness policies to reflect the more stringent requirements effective June 30, 2017.

Objective: Our aim was to investigate whether Wisconsin school wellness policies (SWPs) were updated after the Final Rule, measure policy quality change, and describe mechanisms of successful policy change.

Design: From 2016 through 2018, an explanatory sequential mixed-methods study examined change in SWP quality before and after the Final Rule was published.

View Article and Find Full Text PDF

Spinal subarachnoid diverticula in dogs: A review.

Can Vet J

November 2020

Department of Medical Sciences, University of Madison-Wisconsin School of Veterinary Medicine, 2015 Linden Drive, Madison, Wisconsin 53706, USA (Smith); Division of Clinical Neurology Vetsuisse-Faculty, University of Bern, Bern, Switzerland (Guevar).

Spinal subarachnoid diverticula are fluid dilations of the subarachnoid space that can cause a compressive myelopathy in dogs. These diverticula are usually associated with high motion areas in the cervical and caudal thoracic spine. The definitive etiopathogenesis has not been determined but likely involves congenital or acquired causes.

View Article and Find Full Text PDF

A new species of Cyphophthalmi belonging to the Southeast Asian genus Miopsalis Thorell, 1890 is described and illustrated using SEM and confocal microscopy. The species is known from two localities in the northern part of Mindanao and constitutes only the second described Cyphophthalmi species endemic to the Philippines. Sequence data obtained from this species show that it is phylogenetically distinct from two juvenile specimens previously collected from Bangaray Kimlawis (southern Mindanao) in 2009.

View Article and Find Full Text PDF

Case Description: A 10-month-old neutered male mixed breed dog was presented for assessment of poorly controlled seizures.

Clinical Findings: Magnetic resonance imaging of the brain disclosed complete absence of the lateral and third ventricles and mesencephalic aqueduct. Postmortem computed tomographic (CT) imaging and positive contrast cisterno-ventriculography confirmed the lack of a contiguous ventricular system.

View Article and Find Full Text PDF

B-MWW Zeolite: The Case Against Single-Site Catalysis.

Angew Chem Int Ed Engl

April 2020

Department of Chemical and Biological Engineering, University of Madison - Wisconsin, 1415 Engineering Drive, Madison, WI, 53706, USA.

Boron-containing materials have recently been identified as highly selective catalysts for the oxidative dehydrogenation (ODH) of alkanes to olefins. It has previously been demonstrated by several spectroscopic characterization techniques that the surface of these boron-containing ODH catalysts oxidize and hydrolyze under reaction conditions, forming an amorphous B (OH) O (x=0-6) layer. Yet, the precise nature of the active site(s) remains elusive.

View Article and Find Full Text PDF

Rats exposed to postnatal hyperoxia develop right ventricular (RV) dysfunction, mild pulmonary hypertension, and dysregulated cardiac mitochondrial biogenesis when aged to one year, with the degree of cardiac dysfunction and pulmonary hypertension similar to that previously described in young adults born preterm. Here, we sought to understand the impact of postnatal hyperoxia exposure on RV hemodynamic and mitochondrial function across the life span. In Methods, pups from timed-pregnant Sprague-Dawley rats were randomized to normoxia or hyperoxia [fraction of inspired oxygen (), 0.

View Article and Find Full Text PDF

Study Objectives: Prior research has linked obstructive sleep apnea (OSA) to varied cognitive deficits. Additionally, OSA in rapid eye movement (REM) versus non-rapid eye movement (NREM) sleep has been shown to be a stronger predictor of outcomes such as hypertension. The present study aimed to investigate whether OSA-as characterized by the apnea-hypopnea index (AHI)-during REM and NREM sleep is associated with performance on a range of cognitive tasks.

View Article and Find Full Text PDF

Background: The eHealth Literacy Scale (eHEALS) has been widely adopted by researchers to understand how eHealth literacy can be put into context. eHealth researchers need to know how to promote positive health behavior changes across college students, given the importance of the Internet to acquire and use health information. The American College Health Association identified a set of key health issues that affect college students today.

View Article and Find Full Text PDF

The MSLT is Repeatable in Narcolepsy Type 1 But Not Narcolepsy Type 2: A Retrospective Patient Study.

J Clin Sleep Med

January 2018

Center for Sleep Sciences and Medicine, Department of Psychiatry and Behavioral Sciences, Stanford University, School of Medicine, Palo Alto, California.

Study Objectives: To examine repeatability of Multiple Sleep Latency Test (MSLT) results in narcolepsy type 1 (NT1) and narcolepsy type 2 (NT2) according to the criteria of the International Classification of Sleep Disorders, Third Edition (ICSD-3).

Methods: Repeatability of the MSLT was retrospectively evaluated in NT1 (n = 60) and NT2 (n = 54) cases, and controls (n = 15). All subjects had documented HLA-DQB1*06:02 status and/or hypocretin-1 levels from cerebrospinal fluid.

View Article and Find Full Text PDF

Clinical and pathological classification of canine intraocular lymphoma.

Vet Ophthalmol

March 2018

Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA.

The objectives of this retrospective study of 100 dogs with intraocular lymphoma were to describe the histomorphologic and immunohistochemical features of canine intraocular lymphoma, determine the proportion of cases with presumed solitary ocular lymphoma (PSOL) compared to multicentric disease, and assess the clinical outcomes of these patients. Selected cases from Penn Vet Diagnostic Laboratory and Comparative Ocular Pathology Lab of Wisconsin (2004-2015) were evaluated and subtyped using the WHO classification system. Peripheral T-cell lymphoma and diffuse large B-cell lymphoma were the two most common subtypes.

View Article and Find Full Text PDF

Recent applications of metabolomics to advance microbial biofuel production.

Curr Opin Biotechnol

February 2017

Department of Bacteriology, University of Madison Wisconsin, United States. Electronic address:

Biofuel production from plant biomass is a promising source of renewable energy [1]. However, efficient biofuel production involves the complex task of engineering high-performance microorganisms, which requires detailed knowledge of metabolic function and regulation. This review highlights the potential of mass-spectrometry-based metabolomic analysis to guide rational engineering of biofuel-producing microbes.

View Article and Find Full Text PDF

Aspergillus spp. panophthalmitis with intralenticular invasion in dogs: report of two cases.

Vet Ophthalmol

March 2018

Department of Pathobiological Sciences, University of Madison-Wisconsin, 2015 Linden Drive, Madison, WI, 53706, USA.

This case series describes the ocular, clinical and histologic manifestations of disseminated Aspergillosis in two dogs. Two dogs presented for severe unilateral panophthalmitis and secondary glaucoma with positive Aspergillus spp. titers.

View Article and Find Full Text PDF

The objective of this multicentre retrospective study was to describe clinical presentation, treatment and outcome and to determine prognostic factors for dogs with presumed primary colorectal lymphoma (PCRL). A total of 31 dogs were included. The predominant features of PCRL were high grade (n = 18) and immunophenotype B (n = 24).

View Article and Find Full Text PDF