3 results match your criteria: "University of Macaugrid.437123.0[Affiliation]"
Carbon Catabolite Repression Governs Diverse Physiological Processes and Development in Aspergillus nidulans.
mBio
February 2021
Faculty of Health Sciences, University of Macaugrid.437123.0, Macau SAR, China.
Carbon catabolite repression (CCR) is a common phenomenon of microorganisms that enable efficient utilization of carbon nutrients, critical for the fitness of microorganisms in the wild and for pathogenic species to cause infection. In most filamentous fungal species, the conserved transcription factor CreA/Cre1 mediates CCR. Previous studies demonstrated a primary function for CreA/Cre1 in carbon metabolism; however, the phenotype of / mutants indicated broader roles.
View Article and Find Full Text PDFSerine Metabolism Tunes Immune Responses To Promote Survival upon Infection.
mSystems
August 2021
Center for Proteomics and Metabolomics, State Key Laboratory of Biocontrol, Guangdong Key Laboratory of Pharmaceutical Functional Genes, School of Life Sciences, Southern Marine Science and Engineering Guangdong Laboratory (Zhuhai), Sun Yat-sen Universitygrid.12981.33, Guangzhou, People's Republic of China.
Overactive immune response is a critical factor triggering host death upon bacterial infection. However, the mechanism behind the regulation of excessive immune responses is still largely unknown, and the corresponding control and preventive measures are still to be explored. In this study, we find that Nile tilapia, , that died from Edwardsiella tarda infection had higher levels of immune responses than those that survived.
View Article and Find Full Text PDFScreening of Chemical Libraries for New Antifungal Drugs against Aspergillus fumigatus Reveals Sphingolipids Are Involved in the Mechanism of Action of Miltefosine.
mBio
August 2021
Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, Brazil.
Article Synopsis
- Aspergillus fumigatus is a major fungal pathogen that causes aspergillosis, which can become severe in immunocompromised individuals.
- The treatment options for aspergillosis are limited, mainly relying on azole drugs, but resistance to these drugs is increasing, highlighting the need for new antifungal strategies.
- By screening over 1,100 compounds, researchers found miltefosine as a potential antifungal, with a transcription factor called SmiA identified as crucial for the fungus’s response to the drug, affecting sphingolipid regulation.