11 results match your criteria: "University of Louisville-UofL[Affiliation]"
Low dose exposure to dioxins alters hepatic energy metabolism and steatotic liver disease development in a sex-specific manner.
Environ Int
December 2024
Department of Pharmacology and Toxicology, School of Medicine, University of Louisville, Louisville, KY 40202, USA; University of Louisville (UofL) Superfund Research Center, University of Louisville, Louisville, KY 40202, USA; Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, School of Medicine, University of Louisville, Louisville, KY 40202, USA; The Hepatobiology & Toxicology Center, School of Medicine, University of Louisville, Louisville, KY 40202, USA; The Center for Integrative Environmental Health Sciences, University of Louisville, Louisville, KY 40202, USA. Electronic address:
Article Synopsis
- Dioxins, known persistent organic pollutants, are linked to heightened risks of steatotic liver disease (SLD), but their effects based on sex and mixtures are not well understood.
- In a study using low-fat diets, male and female mice were exposed to low doses of specific dioxins, revealing that females had more liver fat and elevated cholesterol levels due to increased gene expression related to fat synthesis.
- The findings showed that low-dose dioxin mixtures disrupt liver function, with female mice experiencing more significant metabolic disturbances compared to males, highlighting potential sex-dependent vulnerabilities.
Clinical Outcomes of Bulk-Fill Resin Composite Restorations: A 10-Year Mapping Review and Evidence Gap Map.
J Esthet Restor Dent
October 2024
Department of Restorative Dentistry, Federal University of Paraíba (UFPB), João Pessoa, Brazil.
Objective: To map the evidence regarding the clinical performance of posterior restorations with bulk-fill resin composites and identify research gaps.
Materials And Methods: This mapping review was conducted following PRISMA-ScR guidelines for scoping reviews, and its protocol was registered on the Open Science Framework platform. Systematic searches were conducted, considering studies published between 2013 and February 2024 in the PubMed, Embase, and Cochrane databases.
All-Soft-Tissue Meniscus Allograft Transplantation With Circumferential Suture Tape Augmentation to Mitigate Hoop Stress and Promote Centralization.
Arthrosc Tech
May 2024
Department of Orthopaedic Surgery, University of Louisville (UofL), Louisville, Kentucky, U.S.A.
Article Synopsis
- Meniscus allograft transplantation (MAT) is a complex surgical procedure that utilizes various fixation techniques, each having its own pros and cons.
- The native meniscus effectively resists hoop stress due to its unique collagen fiber structure, which is not easily replicated in MAT.
- The authors propose using a high-tensile suture tape called InternalBrace to directly alleviate hoop stress and improve meniscus tensioning during the transplantation process.
Scoping review: Effect of surface treatments on bond strength of resin composite repair.
J Dent
January 2024
Department of Restorative Dentistry, Federal University of Paraiba (UFPB), João, Pessoa, Paraíba, Brazil. Electronic address:
Objective: to evaluate the existing evidence on surface treatment techniques employed in resin composite repair and their effect on the repair short- and long-term bond strength.
Data And Source: This scoping review was performed under the PRISMA-ScR guidelines for scoping reviews and registered on the Open Science Framework platform.
Study Selection: A systematic search was conducted in PubMed, Embase, and Scopus and grey literature up to September 2022 without language or date restriction.
Investigating the effects of long-term Aroclor 1260 exposure on fatty liver disease in a diet-induced obesity mouse model.
Front Gastroenterol (Lausanne)
May 2023
Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, School of Medicine, University of Louisville, Louisville, KY, United States.
Article Synopsis
- Polychlorinated biphenyls (PCBs) are toxic substances linked to health issues like liver diseases, particularly toxicant-associated fatty liver disease (TAFLD), which includes conditions such as steatosis and hepatocellular carcinoma.
- * A study was conducted on male mice to investigate the long-term effects of PCB exposure (Aroclor 1260) combined with different diets, finding that prolonged exposure worsened liver disease outcomes in low-fat diet-fed mice, with 25% developing liver cancer.
- * The research concluded that PCB toxicity can exacerbate TAFLD regardless of dietary fat content, indicating a potential change in energy metabolism as a mechanism for the observed health effects.
The authors respond: The impact of COVID 19 on homeless individuals.
Am J Emerg Med
January 2022
Department of Emergency Medicine, University of Louisville (UofL), United States of America.
Fall, Crush, Kick: Mechanisms and Outcomes in a Cohort of Equine-Related Injuries.
Am Surg
April 2023
University of Louisville(UofL), Louisville, KY, USA.
Introduction: The potential for significant traumatic injury to individuals who interact with horses remains high due to animal size, forces applied, and unpredictability. Despite an estimated 30 million riders in the United States annually, few recent publications have addressed this patient population.
Objectives: This study describes characteristics of patients injured in interactions with horses, focusing on mechanism of injury and use of protective equipment.
Equal incidence of COVID-19 among homeless and non-homeless ED patients when controlling for confounders.
Am J Emerg Med
March 2022
Department of Emergency Medicine, University of Louisville (UofL), United States of America.
Introduction: The World Health Organization (WHO) declared severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) a pandemic in March 2020. Theoretically, homeless patients could have disproportionately worse outcomes from COVID-19, but little research has corroborated this claim. This study aimed to examine the demographics and incidence of COVID-19 in homeless vs non-homeless emergency department (ED) patients.
View Article and Find Full Text PDFInteraction among apoptosis-associated sequence variants and joint effects on aggressive prostate cancer.
BMC Med Genomics
April 2012
Department of Pharmacology & Toxicology, School of Medicine, University of Louisville-UofL, Louisville, KY, USA.
Background: Molecular and epidemiological evidence demonstrate that altered gene expression and single nucleotide polymorphisms in the apoptotic pathway are linked to many cancers. Yet, few studies emphasize the interaction of variant apoptotic genes and their joint modifying effects on prostate cancer (PCA) outcomes. An exhaustive assessment of all the possible two-, three- and four-way gene-gene interactions is computationally burdensome.
View Article and Find Full Text PDFNo association between variant N-acetyltransferase genes, cigarette smoking and Prostate Cancer susceptibility among men of African descent.
Biomark Cancer
February 2011
Department of Pharmacology & Toxicology, School of Medicine, University of Louisville (UofL), Louisville, KY, U.S.A.
OBJECTIVE: We evaluated the individual and combination effects of NAT1, NAT2 and tobacco smoking in a case-control study of 219 incident prostate cancer (PCa) cases and 555 disease-free men. METHODS: Allelic discriminations for 15 NAT1 and NAT2 loci were detected in germ-line DNA samples using TaqMan polymerase chain reaction (PCR) assays. Single gene, gene-gene and gene-smoking interactions were analyzed using logistic regression models and multi-factor dimensionality reduction (MDR) adjusted for age and subpopulation stratification.
View Article and Find Full Text PDFExamination of polymorphic glutathione S-transferase (GST) genes, tobacco smoking and prostate cancer risk among men of African descent: a case-control study.
BMC Cancer
November 2009
Department of Pharmacology & Toxicology, University of Louisville (UofL), School of Medicine, 500 South Preston Street, Room 1319 Research Tower, UofL Health Science Center, Louisville, KY 40202, USA.
Background: Polymorphisms in glutathione S-transferase (GST) genes may influence response to oxidative stress and modify prostate cancer (PCA) susceptibility. These enzymes generally detoxify endogenous and exogenous agents, but also participate in the activation and inactivation of oxidative metabolites that may contribute to PCA development. Genetic variations within selected GST genes may influence PCA risk following exposure to carcinogen compounds found in cigarette smoke and decreased the ability to detoxify them.
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