54 results match your criteria: "University of London (ICR2UL)[Affiliation]"
Mendelian randomization assessing causal relationship between fibrinogen levels and ischemic stroke.
J Stroke Cerebrovasc Dis
December 2024
Institute of Cardiovascular Research, Royal Holloway University of London (ICR2UL), London TW20 0EX, UK; Department of Neurology, Imperial College Healthcare NHS Trust, UK. Electronic address:
Objective: High fibrinogen levels are associated with an increased risk of ischaemic stroke (IS). We used mendelian randomisation (MR) to explore a potential causal relationship.
Materials And Methods: Data for assessing the relationship between gene variant, disease and biological levels needed for a MR approach was collected using a meta-analytical approach.
Prediction of Long-Term Poor Clinical Outcomes in Cerebral Venous Thrombosis Using Neural Networks Model: The BEAST Study.
Int J Gen Med
July 2024
Department of Biological Sciences, Institute of Cardiovascular Research, Royal Holloway University of London (ICR2UL), Egham, Greater London, UK.
Introduction: Risk prediction models are commonly performed with logistic regression analysis but are limited by skewed datasets. We utilised neural networks (NNs) model to identify independent predictors of poor outcomes in cerebral venous thrombosis (CVT) due to the limitations of logistic regression (LR) analysis with complex datasets.
Methods: We evaluated 1309 adult CVT patients from the prospective BEAST (Biorepository to Establish the Aetiology of Sinovenous Thrombosis) study.
Gene-Gene Interaction Between Factor- and Genes in Cerebral Venous Thrombosis: The BEAST Study.
Neurology
June 2024
From the Institute of Cardiovascular Research Royal Holloway (G.K.-D., P.S.), University of London (ICR2UL), United Kingdom; Fondazione IRCCS Ca'Granda-Ospedale Maggiore Policlinico (I.M., S.M.P., M.A., P.B., E.P.), A. Bianchi Bonomi Hemophilia and Thrombosis Center, Milan, Italy; Moncucco Hospital Group (I.M., E.G.), Lugano, Switzerland; Atherosclerosis and Thrombosis Unit (E.G., G.F., D.C.), I.R.C.C.S. Fondazione "Casa Sollievo della Sofferenza", S. Giovanni Rotondo; Medical and Surgical Department (E.G.), University of Foggia, Italy; Department of Obstetrics (E.G.), Gynaecology and Perinatal Medicine, First Sechenov University, Moscow, Russia; Neurology (S.H., J.P., E.H., T.T.), Helsinki University Hospital and University of Helsinki, Finland; Department of Clinical Neuroscience (E.L., K.J., T.T.), Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg; Department of Neurology (E.L., K.J., T.T.), Sahlgrenska University Hospital, Gothenburg, Sweden; Medical Genetics (M. Margaglione, R.S.), Department of Clinical and Experimental Medicine, University of Foggia, Italy; Normandy University (V.L.C.D.), UNIROUEN, INSERM U1096, Rouen University Hospital, Vascular Hemostasis Unit and INSERM CIC-CRB 1404; Department of Neurology (A.B.T.), Rouen University Hospital, France; Neurology Unit (M.Z.), Stroke Unit, Azienda Unità Sanitaria Locale-IRCCS of Reggio Emilia; Department of Clinical and Experimental Medicine (M. Mancuso), Neurological Institute, University of Pisa, Italy; UMC Utrecht Brain Center (Y.M.R.), Department of Neurology and Neurosurgery, University Medical Center Utrecht, the Netherlands; Department of Neurology (B.B.W.), University of Virginia, Charlottesville, VA; Department of Neurology (J.J.M., A.T.), University of Utah, Salt Lake City; Department of Neurology (S.Z., M.C.B., J.M.C.), Amsterdam University Medical Centers, location AMC, Amsterdam Neuroscience, University of Amsterdam, the Netherlands; Department of Neurosciences (R.L.), Experimental Neurology, KU Leuven-University of Leuven; VIB Center for Brain & Disease Research; Department of Neurology, University Hospitals Leuven, Belgium; Department of Pathophysiology and Transplantation (E.P.), Università degli Studi di Milano, Milan; Department of Clinical and Experimental Sciences (P. Costa), Neurology Clinic; Division of Biology and Genetics (M.C.), Department of Molecular and Translational Medicine, University of Brescia, Italy; Stroke Center (D.A.D.S.), Centro Hospitalar Universitário Lisboa Central; CEEM and Institute of Anatomy (D.A.D.S.), Faculdade de Medicina; Instituto de Medicina Molecular João Lobo Antunes (D.A.D.S., J.M.F.), Universidade de Lisboa; Department of Neurosciences (S.G.R., P. Canhao), Hospital of Santa Maria, University of Lisbon, Portugal; Stroke Clinic (A.A.), National Institute of Neurology and Neurosurgery Manuel Velasco Suarez, Mexico City; Department of Neurology (K.S.), University of Athens School of Medicine, Eginition Hospital, Athens, Greece; McMaster University (A.H., R.D., G.P.), Pathology and Molecular Medicine, Population Health Research Institute and Thrombosis and Atherosclerosis Research Institute, Hamilton Health Sciences, Hamilton, Ontario, Canada; Department of Medicine and Surgery (A.P.), University of Parma, Stroke Care Program, Department of Emergency, Parma University Hospital, Italy; Stroke Division (V.N.T.), Florey Institute of Neuroscience and Mental Health, University of Melbourne, Heidelberg, Victoria, Australia; and Department of Clinical Neuroscience (P.S.), Imperial College Healthcare NHS Trust, London, United Kingdom.
Article Synopsis
- Gene-gene interactions are believed to play a significant role in the development of multifactorial diseases like cerebral venous thrombosis (CVT), highlighting potential causes of unexplained heritability.
- A study involving 882 CVT patients and 1,205 control participants found that specific gene variants significantly increased the likelihood of developing CVT, particularly when individuals had certain blood types.
- The research concluded that the interactions between specific genes could raise the risk of CVT by as much as 14 times, underscoring the importance of understanding these genetic factors in disease etiology.
Coma in adult cerebral venous thrombosis: The BEAST study.
Eur J Neurol
August 2024
Institute of Cardiovascular Research Royal Holloway, University of London (ICR2UL), London, UK.
Article Synopsis
- - The study investigates how age, sex, and imaging features relate to coma in patients with cerebral venous thrombosis (CVT), using data from a large international study.
- - Among 596 adult CVT patients, 8.9% experienced coma, with a higher prevalence in men (13.1%) compared to women (7.5%), despite CVT being more common in women.
- - Findings suggest that male sex and older age are significant factors linked to coma in CVT cases, highlighting a complex interplay between gender and clinical outcomes.
Objectives: We compared the safety and efficacy of direct oral anticoagulants (DOACs) with those of warfarin in the long-term (≥6 months) treatment of cerebral venous thrombosis (CVT).
Methods: We searched electronic databases up to November 2023 to compare the use of DOACs and warfarin in CVT management. Modified Rankin scores (mRS), new intracranial hemorrhage, all-cause mortality, recurrence and nonrecanalisation events were used to assess outcome.
Cigarette smoking as a risk factor for ischaemic stroke in young South Asian male migrants to Qatar: The BRAINS study.
Qatar Med J
December 2023
Institute of Cardiovascular Research, Royal Holloway University of London (ICR2UL), United Kingdom Email: https://orcid.org/0000-0003-3641-7441.
Background: The incidence of stroke in the Middle East is high, given its relatively young population. Smoking is a well-recognized risk factor for ischaemic stroke, and its high regional prevalence may partly account for this increased stroke risk. This research aims to determine whether young male South Asian migrants in Qatar were adversely affected by stroke depending on their smoking status.
View Article and Find Full Text PDFABO blood group associated with cerebral venous thrombosis after Oxford-AstraZeneca COVID-19 vaccination: a case-control study.
J R Soc Med
February 2024
Institute of Cardiovascular Research Royal Holloway, University of London (ICR2UL), London TW20 0EX, UK.
Article Synopsis
- The study aimed to explore if blood type affects the risk of developing cerebral venous thrombosis (CVT) after receiving the AstraZeneca COVID-19 vaccine.
- Conducted as a case-control study, it compared vaccinated patients who developed CVT with unvaccinated patients, focusing on the frequency of blood types in each group.
- Results indicated that blood group O was significantly more common in vaccinated CVT patients compared to unvaccinated ones, while blood group A was less prevalent in the vaccinated group, suggesting a potential link between blood type and vaccine-related complications.
Pathophysiology, diagnosis and management of cerebral venous thrombosis: A comprehensive review.
Medicine (Baltimore)
December 2023
Institute of Cardiovascular Research, Royal Holloway University of London (ICR2UL), Egham Hill, Greater London, United Kingdom.
Article Synopsis
- - Cerebral venous thrombosis (CVT) is a rare type of stroke mainly affecting young women, often presenting with vague symptoms like headache or loss of consciousness, which complicates diagnosis.
- - Females are three times more likely to be affected and typically present at a younger age than males; MRI with venography is crucial for accurate diagnosis.
- - Treatment primarily involves heparin, but in severe cases, endovascular procedures may be necessary; around 80% of patients recover well, although there's a mortality rate between 5% and 10%.
Diabetes mellitus and obesity among South Asians with ischemic stroke across three countries.
Int J Stroke
February 2024
Institute of Cardiovascular Research Royal Holloway, University of London (ICR2UL), London, UK.
Article Synopsis
- * While White British patients had a higher body mass index (BMI) over 27 kg/m², South Asians had greater waist circumference, indicating different patterns of obesity.
- * The study highlights the health disparities in diabetes and obesity among South Asians, suggesting a need for targeted public health strategies in countries with large South Asian populations.
Blood group and ischemic stroke, myocardial infarction, and peripheral vascular disease: A meta-analysis of over 145,000 cases and 2,000,000 controls.
J Stroke Cerebrovasc Dis
August 2023
Institute of Cardiovascular Research, Royal Holloway University of London (ICR2UL), London TW20 0EX, UK; Department of Neurology, Imperial College Healthcare NHS Trust, UK. Electronic address:
Objective: Cardiovascular illnesses have been associated to ABO blood types, specifically through an effect on von Willebrand factor and factor FVIII levels. We conducted a meta-analysis to comprehensively explore the relationship between blood groups and ischemic stroke, myocardial infarction, and peripheral vascular disease.
Materials And Methods: A comprehensive meta-analysis was undertaken to investigate blood groups and ischemic stroke (IS), myocardial infarction (MI) and peripheral vascular disease (PVD).
ChAdOx1 nCoV-19 AstraZeneca COVID-19 vaccine.
JRSM Cardiovasc Dis
April 2023
Institute of Cardiovascular Research, Royal Holloway University of London (ICR2UL), London, UK.
A woman in her mid-twenties was admitted with headache, ultimately leading to a diagnosis of cerebral venous sinus thrombosis 10 days after receiving a first dose of the AstraZeneca ChAdOx1 nCoV-19 vaccine (Vaxzevria). We report this case from clinical investigations to outcomes and discuss the issues raised by it regarding the ChAdOx1 nCoV-19 vaccine.
View Article and Find Full Text PDFAge of onset of cerebral venous thrombosis: the BEAST study.
Eur Stroke J
March 2023
Institute of Cardiovascular Research Royal Holloway, University of London (ICR2UL), London, UK.
Article Synopsis
- Cerebral venous thrombosis (CVT) is a rare type of stroke primarily affecting young adults, and this study investigates how age and gender, along with specific risk factors, influence its onset.
- Data were collected from a large, international study (BEAST) involving 1,309 CVT patients, revealing that the average age at onset for women is significantly younger (37 years) than for men (46 years).
- Findings indicate that women with risk factors like pregnancy or oral contraceptive use experience CVT much earlier, sometimes up to 12 years before men, highlighting the critical role of gender in CVT onset.
Atrial fibrillation in UK South Asian hospitalized ischemic stroke patients: The BRAINS study.
PLoS One
February 2023
Institute of Cardiovascular Research Royal Holloway, University of London (ICR2UL), London, United Kingdom.
Introduction: South Asian diaspora comprise one of the largest ethnic minority groups in the world yet data about atrial fibrillation (AF) in this demographic is understudied. Our aim is to identify differences in AF prevalence and treatment between South Asians and white British stroke patients.
Method: The UK arm of a prospective ongoing large international repository on stroke was analysed.
Radiomics-Derived Brain Age Predicts Functional Outcome After Acute Ischemic Stroke.
Neurology
February 2023
From the J. Philip Kistler Stroke Research Center (M.B., A.K.B., M.D.S., S.H., A. Dalca, K.D., A.-K.G., M.R.E., P.M.R., M.N., R.W.R., C.W., N.S.R.), A.A. Martinos Center for Biomedical Imaging (A. Dalca, O.W.), and Henry and Allison McCance Center for Brain Health (J. Rosand), Massachusetts General Hospital, Harvard Medical School, Boston; Lille Neuroscience & Cognition (M.B., X.L., R. Lopes, G.K.), Inserm, CHU Lille, U1172 and Institut Pasteur de Lille (M.G.), CNRS, Inserm, CHU Lille, US 41 - UMS 2014 - PLBS, Lille University, France; Computer Science and Artificial Intelligence Lab (A. Dalca, C.W., P.G.), Massachusetts Institute of Technology, Cambridge; Division of Preventive Medicine (P.M.R.), Department of Medicine, Brigham and Women's Hospital, Boston, MA; Department of Medicine (O.R.B.), Division of Neurology, University of British Columbia, Vancouver, Canada; Department of Neurology (J.W.C., S.J.K.), University of Maryland School of Medicine and Veterans Affairs Maryland Health Care System, Baltimore, MD; School of Medical Sciences (A. Donatti, A. Sousa), University of Campinas (UNICAMP) and the Brazilian Institute of Neuroscience and Neurotechnology (BRAINN), Campinas, São Paulo; Departments of Neurosurgery (C.G.) and Neurology (R.Z.), Geisinger, Danville, PA; Department of Neurosurgery (C.G.), Christian Doppler Klinik, Paracelsus Medical University, Salzburg, Austria; Division of Emergency Medicine (Laura Heitsch), Washington University School of Medicine, St. Louis; Department of Neurology (Laura Heitsch, C.-L.P.), Washington University School of Medicine & Barnes-Jewish Hospital, St. Louis, MO; Department of Clinical Neuroscience (L. Holmegaard, K.J., T.M.S., T.T.), Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg, Sweden; Department of Neurology, Sahlgrenska University Hospital, Gothenburg, Sweden; Department of Neurology (J.J.-C.), Neurovascular Research Group (NEUVAS), IMIM-Hospital del Mar (Institut Hospital del Mar d'Investigacions M`ediques), Universitat Autonoma de Barcelona, Spain; Department of Neurosciences (R. Lemmens), Experimental Neurology and Leuven Research Institute for Neuroscience and Disease (LIND), KU Leuven - University of Leuven, Belgium; Department of Neurology (R. Lemmens), Laboratory of Neurobiology, VIB Vesalius Research Center, University Hospitals Leuven, Belgium; School of Medicine and Public Health (C.R.L.), University of Newcastle, New South Wales; Department of Neurology, John Hunter Hospital, Newcastle, New South Wales, Australia; Division of Endocrinology (P.F.M.), Diabetes and Nutrition, Department of Medicine, University of Maryland School of Medicine, Baltimore; Department of Pharmacotherapy and Translational Research and Center for Pharmacogenomics (C.W.M.), University of Florida, Gainesville; Department of Neurology (J.F.M.), Mayo Clinic, Jacksonville, FL; Klinik und Poliklinik für Neurologie (A.R.), Universitätsmedizin Rostock, Germany; Department of Neurology (S.R., R.S.), Clinical Division of Neurogeriatrics, Medical University Graz, Austria; Center for Genomic Medicine (J. Rosand), Massachusetts General Hospital, Boston; Broad Institute (J. Rosand), Cambridge, MA; Department of Neurology and Evelyn F. McKnight Brain Institute (J. Roquer, T.R., R.L.S./M.S.), Miller School of Medicine, University of Miami, FL; Institute of Cardiovascular Research (P.S.), Royal Holloway University of London (ICR2UL), UK St Peter's and Ashford Hospitals, Egham, United Kingdom; Department of Neurology (A. Slowik), Jagiellonian University Medical College, Krakow, Poland; Division of Neurocritical Care & Emergency Neurology (D.S.), Department of Neurology, Helsinki University Central Hospital, Finland; Stroke Division (V.T.), Florey Institute of Neuroscience and Mental Health, Heidelberg; Department of Neurology (V.T.), Austin Health, Heidelberg, Australia; Departments of Radiology (A.V.) and Neurology and Rehabilitation Medicine (D.W.), University of Cincinnati College of Medicine, OH; Department of Clinical Sciences Lund, Radiology (J.W.) and Neurology (A.G.L.), Lund University, Sweden; Department of Radiology, Neuroradiology, Skåne University Hospital, Malmö, Sweden; Departments of Neurology and Public Health Sciences (B.B.W.), University of Virginia, Charlottesville, VA; University of Technology Sydney (J.M.), Australia; Section of Neurology (A.G.L.), Skåne University Hospital, Lund, Sweden; Department of Laboratory Medicine (C.J.), Institute of Biomedicine, the Sahlgrenska Academy, University of Gothenburg, Sweden; and Department of Clinical Genetics and Genomics (C.J.), Sahlgrenska University Hospital, Region Västra Götaland, Gothenburg, Sweden.
Background And Objectives: While chronological age is one of the most influential determinants of poststroke outcomes, little is known of the impact of neuroimaging-derived biological "brain age." We hypothesized that radiomics analyses of T2-FLAIR images texture would provide brain age estimates and that advanced brain age of patients with stroke will be associated with cardiovascular risk factors and worse functional outcomes.
Methods: We extracted radiomics from T2-FLAIR images acquired during acute stroke clinical evaluation.
The relevance of rich club regions for functional outcome post-stroke is enhanced in women.
Hum Brain Mapp
March 2023
J. Philip Kistler Stroke Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
This study aimed to investigate the influence of stroke lesions in predefined highly interconnected (rich-club) brain regions on functional outcome post-stroke, determine their spatial specificity and explore the effects of biological sex on their relevance. We analyzed MRI data recorded at index stroke and ~3-months modified Rankin Scale (mRS) data from patients with acute ischemic stroke enrolled in the multisite MRI-GENIE study. Spatially normalized structural stroke lesions were parcellated into 108 atlas-defined bilateral (sub)cortical brain regions.
View Article and Find Full Text PDFIschaemic stroke in South Asians: The BRAINS study.
Eur J Neurol
February 2023
Institute of Cardiovascular Research Royal Holloway, University of London (ICR2UL), London, UK.
Background And Purpose: Studies on stroke in South Asian populations are sparse. The aim of this study was to compare differences in age of onset of ischaemic stroke in South Asian patients living in the United Kingdom and South Asian patients living in India versus White British stroke patients.
Methods: We studied the UK and Indian arms of the ongoing BRAINS study, an international prospective hospital-based study of South Asian stroke patients.
Deep profiling of multiple ischemic lesions in a large, multi-center cohort: Frequency, spatial distribution, and associations to clinical characteristics.
Front Neurosci
August 2022
Department of Clinical Sciences Lund, Radiology, Lund University, Lund, Sweden.
Background Purpose: A substantial number of patients with acute ischemic stroke (AIS) experience multiple acute lesions (MAL). We here aimed to scrutinize MAL in a large radiologically deep-phenotyped cohort.
Materials And Methods: Analyses relied upon imaging and clinical data from the international MRI-GENIE study.
Association of Stroke Lesion Pattern and White Matter Hyperintensity Burden With Stroke Severity and Outcome.
Neurology
September 2022
From the J. Philip Kistler Stroke Research Center (A.K.B., S.H., M.B., M.D.S., R.W.R., E.M.A., K.D., M.N., M.R.E., J. Rosand, N.S.R.), Massachusetts General Hospital, Harvard Medical School, Boston; Univ. Lille (M.B.), Inserm, CHU Lille, U1171-LilNCog (JPARC)-Lille Neurosciences & Cognition, France; Clinic for Neuroradiology (M.D.S.), University Hospital Bonn, Germany; Computer Science and Artificial Intelligence Lab (A. Dalca, P.G.), Massachusetts Institute of Technology, Boston; Athinoula A. Martinos Center for Biomedical Imaging (A. Dalca, B.L.H., S.J.T.M., E.M., J. Rosand, O.W.), Department of Radiology, Massachusetts General Hospital, Charlestown; Department of Neurology (A.-K.G.), University Medical Center Hamburg-Eppendorf, Germany; Hunter Medical Research Institute (J.A.), Newcastle; School of Medicine and Public Health, University of Newcastle, New South Wales, Australia; Department of Medicine (O.B.), Division of Neurology, University of British Columbia, Vancouver, Canada; Department of Neurology (J.W.C., S.K.), University of Maryland School of Medicine and Veterans Affairs Maryland Health Care System, Baltimore; School of Medical Sciences (A. Donatti, A. Sousa), University of Campinas (UNICAMP) and the Brazilian Institute of Neuroscience and Neurotechnology (BRAINN), Campinas, SP, Brazil; Department of Neurosurgery (C.G.), Geisinger, Danville, PA; Department of Neurosurgery (C.G.), Christian Doppler Clinic, Paracelsus Medical University, Salzburg, Austria; Department of Emergency Medicine (L. Heitsch), Washington University School of Medicine; Department of Neurology (L. Heitsch, C.-L.P.), Washington University School of Medicine & Barnes-Jewish Hospital, St. Louis, MO; Department of Clinical Neuroscience (L. Holmegaard, K.J., T.T.), Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg; Department of Neurology, Sahlgrenska University Hospital, Gothenburg, Sweden; Department of Neurology (J.J.-C., J. Roquer), Neurovascular Research Group (NEUVAS), IMIM-Hospital del Mar (Institut Hospital del Mar d'Investigacions Mèdiques), Universitat Autonoma de Barcelona, Spain; KU Leuven-University of Leuven (R.L.), Department of Neurosciences, Experimental Neurology and Leuven Research Institute for Neuroscience and Disease (LIND); VIB, Vesalius Research Center, Laboratory of Neurobiology, University Hospitals Leuven, Department of Neurology, Belgium; School of Medicine and Public Health (C.L.), University of Newcastle; Department of Neurology, John Hunter Hospital, Newcastle, New South Wales, Australia; Department of Pharmacotherapy and Translational Research and Center for Pharmacogenomics (C.W.M.), University of Florida, Gainesville; Department of Neurology (J. Meschia), Mayo Clinic, Jacksonville, FL; Centogene AG (A.R.), Rostock, Germany; Department of Neurology (S.R., R.S.), Clinical Division of Neurogeriatrics, Medical University Graz, Austria; Henry and Allison McCance Center for Brain Health (J. Rosand), Massachusetts General Hospital, Boston; Department of Neurology and Evelyn F. McKnight Brain Institute (T.R., R.L.S.), Miller School of Medicine, University of Miami, FL; Institute of Cardiovascular Research (P.S.), Royal Holloway University of London (ICR2UL), Egham, UK St Peter's and Ashford Hospitals, United Kingdom; Department of Neurology (A. Slowik), Jagiellonian University Medical College, Krakow, Poland; Department of Clinical Sciences Malmö (M.S.), Lund University; Department of Neurology, Skåne University Hospital, Lund and Malmö; Department of Laboratory Medicine (T.M.S., C.J.), Institute of Biomedicine, the Sahlgrenska Academy, University of Gothenburg, Sweden; Department of Neurology (D.S.), Helsinki University Hospital and University of Helsinki, Finland; Stroke Division (V.T.), Florey Institute of Neuroscience and Mental Health and Department of Neurology, Austin Health, Heidelberg, Australia; Department of Radiology (A.V.), University of Cincinnati College of Medicine, OH; Department of Clinical Sciences Lund (J.W.), Radiology, Lund University; Department of Radiology, Neuroradiology, Skåne University Hospital, Lund, Sweden; Department of Neurology and Rehabilitation Medicine (D.W.), University of Cincinnati College of Medicine, OH; Department of Neurology (R.Z.), Geisinger, Danville, PA; Division of Endocrinology (P.M.), Diabetes and Nutrition, Department of Medicine, University of Maryland School of Medicine, Baltimore; Departments of Neurology and Public Health Sciences (B.B.W.), University of Virginia, Charlottesville; Department of Clinical Genetics and Genomics (C.J.), Sahlgrenska University Hospital, Gothenburg; Department of Neurology (A.G.L.), Skåne University Hospital, Lund; Department of Clinical Sciences Lund, Neurology, Lund University, Sweden; University of Technology Sydney (J. Maguire), Australia; Department of Biomedical Engineering (D.B.), McConnell Brain Imaging Centre, Montreal Neurological Institute, Faculty of Medicine, School of Computer Science, McGill University; and Mila-Quebec Artificial Intelligence Institute (D.B.), Montreal, Canada.
Background And Objectives: To examine whether high white matter hyperintensity (WMH) burden is associated with greater stroke severity and worse functional outcomes in lesion pattern-specific ways.
Methods: MR neuroimaging and NIH Stroke Scale data at index stroke and the modified Rankin Scale (mRS) score at 3-6 months after stroke were obtained from the MRI-Genetics Interface Exploration study of patients with acute ischemic stroke (AIS). Individual WMH volume was automatically derived from fluid-attenuated inversion recovery images.
Migraine-Associated Common Genetic Variants Confer Greater Risk of Posterior vs. Anterior Circulation Ischemic Stroke☆.
J Stroke Cerebrovasc Dis
August 2022
Department of Clinical Sciences Lund, Neurology, Lund University, Lund, Sweden; Section of Neurology, Skåne University Hospital, Lund, Sweden.
Objective: To examine potential genetic relationships between migraine and the two distinct phenotypes posterior circulation ischemic stroke (PCiS) and anterior circulation ischemic stroke (ACiS), we generated migraine polygenic risk scores (PRSs) and compared these between PCiS and ACiS, and separately vs. non-stroke control subjects.
Methods: Acute ischemic stroke cases were classified as PCiS or ACiS based on lesion location on diffusion-weighted MRI.
Sex-specific lesion pattern of functional outcomes after stroke.
Brain Commun
February 2022
J. Philip Kistler Stroke Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Stroke represents a considerable burden of disease for both men and women. However, a growing body of literature suggests clinically relevant sex differences in the underlying causes, presentations and outcomes of acute ischaemic stroke. In a recent study, we reported sex divergences in lesion topographies: specific to women, acute stroke severity was linked to lesions in the left-hemispheric posterior circulation.
View Article and Find Full Text PDFExcessive White Matter Hyperintensity Increases Susceptibility to Poor Functional Outcomes After Acute Ischemic Stroke.
Front Neurol
September 2021
J. Philip Kistler Stroke Research Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States.
To personalize the prognostication of post-stroke outcome using MRI-detected cerebrovascular pathology, we sought to investigate the association between the excessive white matter hyperintensity (WMH) burden unaccounted for by the traditional stroke risk profile of individual patients and their long-term functional outcomes after a stroke. We included 890 patients who survived after an acute ischemic stroke from the MRI-Genetics Interface Exploration (MRI-GENIE) study, for whom data on vascular risk factors (VRFs), including age, sex, atrial fibrillation, diabetes mellitus, hypertension, coronary artery disease, smoking, prior stroke history, as well as acute stroke severity, 3- to-6-month modified Rankin Scale score (mRS), WMH, and brain volumes, were available. We defined the unaccounted WMH (uWMH) burden modeling of expected WMH burden based on the VRF profile of each individual patient.
View Article and Find Full Text PDFGenome-Wide Association Study Identifies First Locus Associated with Susceptibility to Cerebral Venous Thrombosis.
Ann Neurol
November 2021
Institute of Cardiovascular Research Royal Holloway, University of London (ICR2UL), London, UK.
Article Synopsis
- Cerebral venous thrombosis (CVT) is a rare type of stroke primarily affecting young people, and its genetic causes are not well understood.
- A genome-wide association study involved 882 CVT patients and 1,205 matched controls to identify genetic factors associated with CVT risk.
- Significant findings highlighted 37 SNPs linked to the 9q34.2 region, with blood groups A, B, or AB having a higher risk for CVT compared to blood group O, suggesting important genetic insights into the condition.
MRI Radiomic Signature of White Matter Hyperintensities Is Associated With Clinical Phenotypes.
Front Neurosci
July 2021
J. Philip Kistler Stroke Research Center, Massachusetts General Hospital, Boston, MA, United States.
Objective: Neuroimaging measurements of brain structural integrity are thought to be surrogates for brain health, but precise assessments require dedicated advanced image acquisitions. By means of quantitatively describing conventional images, radiomic analyses hold potential for evaluating brain health. We sought to: (1) evaluate radiomics to assess brain structural integrity by predicting white matter hyperintensities burdens (WMH) and (2) uncover associations between predictive radiomic features and clinical phenotypes.
View Article and Find Full Text PDFMarkov chain Monte Carlo Gibbs sampler approach for estimating haplotype frequencies among multiple malaria infected human blood samples.
Malar J
July 2021
Institute of Cardiovascular Research, Royal Holloway University of London (ICR2UL), London, TW20 0EX, UK.
Background: Malaria patients can have two or more haplotypes in their blood sample making it challenging to identify which haplotypes they carry. In addition, there are challenges in measuring the type and frequency of resistant haplotypes in populations. This study presents a novel statistical method Gibbs sampler algorithm to investigate this issue.
View Article and Find Full Text PDFOutcome after acute ischemic stroke is linked to sex-specific lesion patterns.
Nat Commun
June 2021
J. Philip Kistler Stroke Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Article Synopsis
- Acute ischemic stroke presents differently in men and women, with women experiencing more severe symptoms compared to men.
- Researchers developed a specialized Bayesian modeling framework to analyze lesion patterns from stroke patients, revealing that extensive brain lesions impact severity differently by sex.
- The study emphasizes that for women, particularly severe strokes are linked to specific brain regions, indicating the need for tailored approaches in treating acute ischemic stroke based on sex differences.