Signatures of self-organized dynamics in rapidly driven critical sandpiles.

We study two prototypical models of self-organized criticality, namely sandpile automata with deterministic (Bak-Tang-Wiesenfeld) and probabilistic (Manna model) dynamical rules, focusing on the nature of stress fluctuations induced by driving-adding grains during avalanche propagation, and dissipation through avalanches that hit the system boundary. Our analysis of stress evolution time series reveals robust cyclical trends modulated by collective fluctuations with dissipative avalanches. These modulated cycles attain higher harmonics, characterized by multifractal measures within a broad range of timescales.

Momentum-dependent quantum Ruelle-Pollicott resonances in translationally invariant many-body systems.

We study Ruelle-Pollicott resonances in translationally invariant quantum many-body lattice systems via spectra of a momentum-resolved operator propagator on infinite systems. Momentum dependence gives insight into the decay of correlation functions, showing that, depending on their symmetries, different correlation functions in general decay with different rates. Focusing on the kicked Ising model, the spectrum seems to be typically composed of an annular random matrix-like ring whose size we theoretically predict, and few isolated resonances.

Recommendations for Transitioning Young People with Primary Immunodeficiency Disorders and Autoinflammatory Diseases to Adult Care.

Purpose: Significant improvements in the prognosis for young patients with Primary Immunodeficiency Diseases (PID) and Autoinflammatory Disorders (AID), which together make up the majority of Inborn Errors of Immunity (IEI), have resulted in the need for optimisation of transition and transfer of care to adult services. Effective transition is crucial to improve health outcomes and treatment compliance among patients. Evaluations of existing transition programmes in European health centres identified the absence of disease-specific transition guidelines for PID and AID, as a challenge to the transition process.

Towards standardization of person-reported outcomes (PROs) in pediatric diabetes research: A consensus report.

Background: Diabetes ranks among the most common chronic conditions in childhood and adolescence. It is unique among chronic conditions, in that clinical outcomes are intimately tied to how the child or adolescent living with diabetes and their parents or carers react to and implement good clinical practice guidance. It is widely recognized that the individual's perspective about the impact of trying to manage the disease together with the burden of self-management should be addressed to achieve optimal health outcomes.

Up-Conversion Photoluminescence Reconfiguration in Silicon by Inner Microstructure Control of Hybrid Plasmonic-Semiconductor Nanoparticles.

Hybrid metal-semiconductor nanostructures unifying plasmonic and high-refractive-index materials in a single resonant system demonstrate a wide set of unique optical properties. Such systems are a perspective for a broad palette of applications, but the link between their inner structure and optical properties is a very sensitive issue, which is still not revealed. Here, we describe the influence of internal microstructure of a hybrid gold-silicon nanoparticle (the gold nanoparticle with embedded silicon nanograins) on the up-conversion white-light photoluminescence.

Computational Psychotherapy System for Mental Health Prediction and Behavior Change with a Conversational Agent.

Background: The importance of computational psychotherapy is increasing due to the record high prevalence of mental health issues worldwide. Despite advancements, current computational psychotherapy systems lack advanced prediction and behavior change mechanisms using conversational agents.

Purpose: This work presents a computational psychotherapy system for mental health prediction and behavior change using a conversational agent.

Three Decades of Adolescent Health: Unveiling Global Trends Across 41 Countries in Psychological and Somatic Complaints (1994-2022).

Objectives: This study examined (non-)monotonic time trends in psychological and somatic complaints among adolescents, along with gender differences.

Methods: Repeated cross-sectional Health Behaviour in School-aged Children (HBSC) data from 1994 to 2022 covering 15-year-old adolescents from 41 countries (N = 470,797) were analysed. Three polynomial logistic regression models (linear, quadratic, cubic) were tested for best fit, including separate analyses by gender and health complaints dimension.

Use of Cabbage Leaf Inverted Flap Technique in the Management of a Stage IV Full-Thickness Macular Hole.

The purpose of this study was to evaluate the anatomical and visual outcomes of patients with stage IV full-thickness macular holes (FTMHs) treated by the cabbage leaf inverted internal limiting membrane (ILM) flap technique. We conducted a retrospective study, enrolling patients with stage IV FTMH operated by a single surgeon. Six patients with FTMH and no other known ocular comorbidities were included in the study.

Magnetic Performance and Anticorrosion Coating Stability of Thermally Demagnetized Nd-Fe-B Permanent Magnets for Reuse Applications.

Nd-Fe-B-type permanent magnets, containing approximately 30% critical rare-earth elements by weight, are essential components in renewable energy systems (e.g., wind turbines, hydroelectric generators) and electric vehicles.

Benefits of Early Integrated and Vocational Rehabilitation in Breast Cancer on Work Ability, Sick Leave Duration, and Disability Rates.

Objectives: Vocational rehabilitation plays a vital role in helping breast cancer survivors overcome physical, psychological, and occupational challenges, enabling a smoother return to work and improving quality of life. The aim of this study was to evaluate the effect of vocational rehabilitation as part of early integrated rehabilitation compared to conventional rehabilitation on sick leave duration, work ability, and disability rates.

Methods: The study was designed as a prospective, interventional study.

Working Carers in Europe and How Their Caring Responsibilities Impact Work-Family Life Conflict: Analysis of the European Quality of Life Survey.

: Ageing of the population is a pertinent characteristic in developed societies that raises questions of who provides care and how care is provided to frail and dependent old people. The majority of care is provided by family members, friends, and neighbours, many of whom are of working age and active in the labour market. The aim of this study is to research how work and care are intertwined and how they cause conflict for individuals in Europe.

Mechanism, Kinetics and Modelling of Phenol Carboxylation Reactions with CO.

Combining carboxylation reactions using carbon dioxide (CO) as a reactant with phenol results in creation of new C-C bonds, and represents one of the most promising routes in sustainable utilization of ubiquitous and readily available resources for production of highly valuable products. This study provides a detailed and well-structured investigation of the effect of various reaction conditions (reactant loading, reaction duration, temperature, CO pressure) on the carboxylation of phenol. Sodium phenoxide carboxylation showed well-resolved trends with variation of temperature and time, and resulted in production of salicylic acid (SA) in the range of 11.

Body Composition Trend in Slovene Adults: A Two-Year Follow-Up.

This research re-evaluates the prevalence of obesity in a cohort of 432 Slovenian adults two years after an initial population-based cross-sectional examination, utilizing the World Health Organization's body mass index (BMI) and total body fat percentage (FAT%) classifications. Herein, a medically approved electrical bioimpedance monitor was used to analyse body composition, and the results revealed a significant increase in the percentage of individuals classified as having overweight or obesity on the basis of BMI, from 40.7% initially to 45.

Supercritical CO Extraction vs. Hexane Extraction and Cold Pressing: Comparative Analysis of Seed Oils from Six Plant Species.

Supercritical fluid extraction using carbon dioxide (SFE-CO) brings a convincing advance in the production of plant oils used in cosmetics, in fortified foods and dietary supplements, and in pharmaceuticals and medicine. The SFE-CO-extracted, hexane-extracted, and cold-pressed plant oils of pumpkin ( L.), flax ( L.

Identification of Phenolic Compounds in the Invasive Plants Staghorn Sumac and Himalayan Balsam: Impact of Time and Solvent on the Extraction of Phenolics and Extract Evaluation on Germination Inhibition.

An HPLC-MS-DAD analysis of phenolic compounds was carried out on the extracts of staghorn sumac ( L.) and Himalayan balsam ( Royle). This study focuses on the influence of solvent type and extraction time on the phenolic extraction efficiency from both invasive plants.

Can the Suspension Method (Tenderstretch vs. Achilles Tendon) Enhance Horsemeat Quality?

This study investigated whether the suspension method (tenderstretch, TS or Achilles tendon, AT) can improve the quality of horsemeat by analyzing longissimus dorsi (LD) and semitendinosus (ST) muscles. A total of 25 horse carcasses were considered experimental units and split longitudinally, with one half suspended using the TS method and the other half using the AT method, which enabled a direct comparison within the carcass. After 7 days of aging under commercial processing conditions, the LD and ST muscles were analyzed for pH, color (L*, a*, b*), water-holding capacity (drip loss, thawing loss, cooking loss), tenderness (Warner-Bratzler shear force), and sarcomere length.

FoxP3 Regulatory T-Cell Quantities in Nodal T-Follicular Helper Cell Lymphomas and Peripheral T-Cell Lymphomas Not Otherwise Specified and Their Impact on Overall Survival.

Background/objectives: The tumour microenvironment (TME) plays an important role in the development and progression of cancer and it differs among lymphomas, both with respect to the composition and quantity of specific tumour-infiltrating immune cells (TICs), such as FoxP3 regulatory T cells (Tregs). The role of FoxP3 Tregs in the TME of peripheral T-cell lymphomas (PTCLs) is complex, and their impact on overall survival (OS) remains unclear. Consequently, we aim to evaluate and compare the FoxP3 cell quantity in nodal PTCLs and reactive lymph nodes (LNs), with a focus on investigating their impact on OS.

DNA Methylation Panels for the Differentiation of Lung and Gastric Adenocarcinomas from Other Common Primary Adenocarcinomas.

: Gastric and lung adenocarcinomas are among the most common adenocarcinomas worldwide. Our research aimed to validate methylation biomarkers that differentiate gastric and lung adenocarcinomas from hepatocellular carcinoma, cholangiocarcinoma, colorectal carcinoma, pancreatic adenocarcinoma and paired healthy tissues. : The study analyzed 178 formalin-fixed, paraffin-embedded tissue samples, including 14 gastric adenocarcinomas, 15 lung adenocarcinomas, 15 hepatocellular carcinomas, 15 cholangiocarcinomas, 15 colorectal carcinomas, 15 pancreatic adenocarcinomas and their paired healthy tissues.

Nanobubble nucleation by pulsed laser illumination of colloidal gold nanoparticles.

This study expands upon a technique our team previously developed for generating nanobubbles on demand with a collimated pulsed laser beam. This work highlights how the controlled addition of gold nanoparticles enhances nanobubble generation efficiency in water, even at laser intensities well below the threshold for multiphoton ionization. Specifically, we investigated the influence of nanoparticles of three distinct sizes on the laser fluence threshold for bubble nucleation and the lifetime of the resultant nanobubbles.

Neuropsin, TRPV4 and intracellular calcium mediate intrinsic photosensitivity in corneal epithelial cells.

Purpose: To investigate intrinsic phototransduction in the corneal epithelium and its role in intracellular and inflammatory signaling.

Methods: Optical imaging in isolated corneal epithelial cells (CECs) and debrided epithelia was combined with molecular, biochemical, pharmacological assays and gene deletion studies to track UVB-induced calcium signaling and release of cytokines, chemokines and matrix remodeling enzymes. Results from wild type mouse CECs were compared to data obtained from Opn5 and Trpv4 cells.

Moss biomonitoring of lithogenic impact on the distribution of various chemical elements in the air in the region of Mariovo, North Macedonia.

A study was conducted to investigate the air deposition and explore the distribution of potentially toxic elements in the Mariovo region, North Macedonia, using moss samples as biomonitors of air pollution. The distribution of 44 chemical elements was detected in 20 moss samples collected in the area. The moss samples were analyzed after microwave digestion using inductively coupled plasma - atomic emission spectrometry (ICP-AES) and inductively coupled plasma-mass spectrometry (ICP-MS).

Sequelae of B-Cell Depleting Therapy: An Immunologist's Perspective.

B-cell depleting therapy (BCDT) has revolutionised the treatment of B-cell malignancies and autoimmune diseases by targeting specific B-cell surface antigens, receptors, ligands, and signalling pathways. This narrative review explores the mechanisms, applications, and complications of BCDT, focusing on the therapeutic advancements since the introduction of rituximab in 1997. Various monoclonal antibodies and kinase inhibitors are examined for their roles in depleting B cells through antibody-dependent and independent mechanisms.