24 results match your criteria: "University of Liverpool and Liverpool University Hospitals NHS Foundation Trust[Affiliation]"

Article Synopsis
  • The study investigates the relationship between metabolic syndrome (MetS) components and the risk of micro- and macrovascular diseases in patients with metabolic dysfunction-associated steatotic liver disease (MASLD).
  • It used a retrospective cohort analysis of patient records, comparing those with hepatic steatosis and MetS components to those without, looking at how increasing numbers of MetS factors affect disease risk.
  • Results show that MASLD, especially with multiple MetS components, significantly increases the risk for both microvascular (like neuropathy and retinopathy) and macrovascular (like heart attacks and strokes) diseases, with specific MetS factors linked to different levels of risk.
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Chaiqin chengqi decoction treatment mitigates hypertriglyceridemia-associated acute pancreatitis by modulating liver-mediated glycerophospholipid metabolism.

Phytomedicine

November 2024

West China Centre of Excellence for Pancreatitis, Institute of Integrated Traditional Chinese and Western Medicine, West China-Liverpool Biomedical Research Centre, West China Hospital, Sichuan University, Chengdu, 610041, China. Electronic address:

Background: The incidence of hypertriglyceridemia-associated acute pancreatitis (HTG-AP) is increasing globally and more so in China. The characteristics of liver-mediated metabolites and related key enzymes are rarely reported in HTG-AP. Chaiqin chengqi decoction (CQCQD) has been shown to protect against AP including HTG-AP in both patients and rodent models, but the underlying mechanisms in HTG-AP remain unexplored.

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Background And Aim: This study aimed to compare the determinants and impact of hepatocellular carcinoma (HCC) surveillance rates for people with metabolic dysfunction-associated steatotic liver disease (MASLD) versus other chronic liver diseases.

Methods: A dataset of HCC patients from a UK hospital (2007-2022) was analyzed. The Mann-Whitney U-test compared continuous variables.

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Article Synopsis
  • The study aimed to assess the effectiveness of ECG in detecting cardiac issues in post-hospitalized COVID-19 patients through cardiac magnetic resonance (CMR) imaging.
  • Results showed that these patients had significantly more ECG abnormalities compared to healthy controls, yet both groups had similar levels of CMR abnormalities.
  • Adding additional analyses on repolarization improved ECG's ability to identify patients with CMR abnormalities and reduced the reliance on sex in the diagnostic process.
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Article Synopsis
  • - Sodium-glucose cotransporter 2 inhibitors (SGLT2is) not only help lower glucose levels in type 2 diabetes (T2D) patients but also provide significant heart and kidney benefits, especially in preventing heart failure hospitalizations and cardiovascular deaths.
  • - A study analyzed over 480,000 heart failure patients without diabetes, comparing those on SGLT2is with others on different treatments, finding that SGLT2is significantly lowered the risk of developing T2D.
  • - The reduction in T2D incidence was most notable among patients with prediabetes, with dapagliflozin showing a stronger effect than empagliflozin in preventing new cases of diabetes.
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Introduction: Wearable neuromuscular and biomechanical biofeedback technology has the potential to improve patient outcomes by facilitating exercise interventions. We will conduct a systematic review to examine whether the addition of wearable biofeedback to exercise interventions improves pain, disability and quality of life beyond exercise alone for adults with chronic non-specific spinal pain. Specific effects on clinical, physiological, psychological, exercise adherence and safety outcomes will also be examined.

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Aim: To evaluate the impact of denosumab on (i) the incidence of type 2 diabetes (T2D), and (ii) long-term health outcomes (microvascular [neuropathy, retinopathy, nephropathy] and macrovascular [cardiovascular disease, cerebrovascular accident] complications, and all-cause mortality) in patients with T2D, before (iii) combining results with prior studies using meta-analysis.

Methods: A retrospective analysis of data in a large global federated database (TriNetX; Cambridge, MA) was conducted from 331 375 patients, without baseline T2D or cancer, prescribed either denosumab (treatment, n = 45 854) or bisphosphonates (control, n = 285 521), across 83 healthcare organizations. Propensity score matching (1:1) of confounders was undertaken that resulted in 45 851 in each cohort.

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Article Synopsis
  • - The rising rates of obesity in older adults (60+) pose challenges due to potential health risks, including a mix of complications like cardiovascular issues and cognitive decline, while also raising concerns about the negative effects of weight loss on muscle and bone mass.
  • - Lifestyle interventions, particularly resistance training, are critical for managing obesity in this age group, but for those struggling to lose weight, anti-obesity medicines (AOMs) have become a viable option as recent findings support their safety and effectiveness in older populations.
  • - While nine AOMs are approved for treating obesity, most research focuses on glucagon-like peptide-1 receptor agonists, indicating a need for more studies to assess the long-term benefits and impacts of new A
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Article Synopsis
  • People with neuroendocrine neoplasms (NENs) encounter significant challenges such as delayed diagnosis and lack of awareness among healthcare providers, leading to limited access to proper care.
  • A new patient care pathway was developed in England to improve disease management for NEN patients, incorporating feedback from literature reviews and expert interviews.
  • This pathway aims to identify and address care barriers, promoting equitable treatment across the UK, and is designed to integrate into existing multidisciplinary teams within the NHS.
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Article Synopsis
  • The study investigates the effects of molnupiravir on viral clearance, antibody response, and mutagenesis in non-hospitalized individuals within 5 days of experiencing COVID-19 symptoms, comparing it to usual care.
  • Results show that while molnupiravir accelerates the decline of viral load, many participants still test positive for the virus 5 days later, and significantly lower antiviral antibodies are observed after 14 days compared to those receiving usual care.
  • Serial sequencing suggests that treatment with molnupiravir leads to increased mutations of the virus, raising concerns about the emergence of potentially transmissible variants, indicating that the current treatment duration may be insufficient.
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Background: Elective neck dissection improves survival in early oral cancer. Sentinel lymph node biopsy may also do this with less morbidity. This systematic review compared health-related quality of life, functional outcomes, and complications after sentinel lymph node biopsy and elective neck dissection in early oral cancer.

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Introduction: Multiple drug-resistant Gram-negative bacterial (MDR-GNB) bacteraemia poses a serious threat to patients in hospital. Infected pancreatic necrosis (IPN) patients are a vulnerable population to infectious complications during hospitalization. This study aims to evaluate the impact of MDR Gram-negative bacteraemia on IPN patients.

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Insulin based treatment or blood purification for hypertriglyceridaemia-associated acute pancreatitis: Our reply.

Pancreatology

January 2023

West China Centre of Excellence for Pancreatitis, Institute of Integrated Traditional Chinese and Western Medicine, West China-Liverpool Biomedical Research Centre, West China Hospital, Sichuan University, Chengdu, China. Electronic address:

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Objective: The objective of this study is to generate a core clinical dataset (CD) containing the minimum acceptable amount of information that should be collected for each patient presenting with triglyceride-induced acute pancreatitis within global treatment centres or sites.

Method: The Jandhyala Method, including systematic literature review and SMART interviews, was used to observe expert opinion from ten leaders in the treatment of triglyceride-induced acute pancreatitis (TG-IAP) across the US and EU.

Results: Using the PRISMA Literature Review Protocol, data were extracted from 123 of the 6718 identified studies.

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Background: Acute pancreatitis (AP) is a common digestive disease with increased incidence globally but without internationally licenced pharmacological therapy. Moderately severe and severe acute pancreatitis (MSAP/SAP) contributes predominately for its morbidities and mortality and has been managed in West China Hospital for decades using the traditional Chinese medicinal formula chaiqin chengqi decoction (CQCQD). The current study tests whether the early administration of CQCQD will result in improved clinical outcomes in predicted MSAP/SAP patients.

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Alcohol abuse, an increasing problem in developed societies, is one of the leading causes of acute and chronic pancreatitis. Alcoholic pancreatitis is often associated with fibrosis mediated by activated pancreatic stellate cells (PSCs). Alcohol toxicity predominantly depends on its non-oxidative metabolites, fatty acid ethyl esters, generated from ethanol and fatty acids.

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Background/objectives: Hypertriglyceridaemia increases risks from acute pancreatitis (HTG-AP) over other aetiologies, but optimal management for HTG-AP remains undefined. We performed a systematic review and meta-analysis of studies of insulin-based treatment (IT) versus blood purification treatment (BPT) for HTG-AP.

Methods: Searches were conducted to identify randomised trials and observational studies published between 1946 and 2022 that compared IT and BPT for HTG-AP reporting baseline and post-treatment serum triglyceride (TG) levels with clinical outcomes.

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Article Synopsis
  • Acute pancreatitis (AP) is a serious inflammation of the pancreas, and identifying patients at high risk of severe complications early is essential to prevent organ failure and death.
  • The study developed a machine learning prediction model called EASY, using data from over 4,700 patients to offer quick assessments of severity through algorithms like XGBoost, achieving an average accuracy of 89.1%.
  • The model identifies key risk factors such as respiratory rate, body temperature, and glucose level, and includes a user-friendly web application for easy access to its predictions.
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Background: Intra-abdominal hypertension (IAH) in acute pancreatitis (AP) is associated with deterioration in organ function. This trial aimed to assess the efficacy of neostigmine for IAH in patients with AP.

Methods: In this single-center, randomized trial, consenting patients with IAH within 2 weeks of AP onset received conventional treatment for 24 h.

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Aims: Despite the benefits of exercise training in the secondary prevention of cardiovascular disease, there are conflicting findings for the impact of exercise-based cardiac rehabilitation (CR) on mortality for patients with heart failure (HF). The aim of this study was therefore to investigate the association of exercise-based CR with all-cause mortality, hospitalisation, stroke, and atrial fibrillation in patients with heart failure.

Methods And Results: A retrospective cohort study was conducted which utilized a global federated health research network, primarily in the USA.

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Parenchymal pressure injury Ca entry mechanism in pancreatitis.

Cell Calcium

April 2020

Liverpool Pancreatitis Research Group, Institute of Translational Medicine, University of Liverpool and Liverpool University Hospitals NHS Foundation Trust, Liverpool, UK. Electronic address:

Pancreatic trauma and high parenchymal pressure have been found to open Piezo1 plasma membrane Ca channels to such an extent that transient receptor potential vanilloid type 4 channels also open to further Ca entry, overloading the cell with Ca to induce acute pancreatitis (Swain et al, J Clin Invest, 2020). Elucidation of this mechanism is an important step in understanding pancreatitis and opens up new possibilities for prevention and treatment.

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Podcast recording of Editorial Board Members Uazman Alam and Shazli Azmi live from the EASD 2019 conference in Barcelona (MP4 377292 kb).

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